A Review on Analytical and Pharmacological Description of Ornidazole
DOI:
https://doi.org/10.63682/jns.v14i7.7289Keywords:
Ornidazole, Nitroimidazole, RP-HPLC, Anaerobic bacteriaAbstract
Ornidazole is a well-known Anti-bacterial drug associated with the Nitroimidazole class. It’s a class II BCS compound with poor solubility in inorganic solvents. Hoffmann-La-Roche synthesized orinidazole in 1966. Anaerobic bacteria are susceptible to the antibacterial and antiprotozoal effect of ornidazole. This review mainly focuses on various analytical estimations techniques of ornidazole and compares it with other drug compounds. This is a comprehensive review of previous research on the drug ornidazole
Downloads
Metrics
References
M. Hoffer (Hoffmann-la-Roche), Neth. Pat. Appl. Nl 6606853 (1966); Chem. Abs., 68, 21933...
S. Budavari Eds. In. The Merck Index. (Merck & Co.,Inc), Whitehouse Station, NJ. 2001, 13th Ed:1213 and 1229.
M.E. Swartz, I.S. Krull, Analytical Method Development and Validation, Marcel Dekker, New York, 1997.
Kumar T, Chitra A, Amrithraj V, and Kumar N: New RPHPLC Method Development and Validation for Estimation of Levofloxacin in Tablet Dosage Form. Journal of Global Trends in Pharmaceutical Sciences 2011; 2: 264–276.
Jain R, Jain N, Maheswari RK and Jain SK: Quantitative estimation of Levofloxacin and Ornidazole by UV Spectrophotometer: a mixed Hydrotropy solubilization approach. International Journal of Pharmaceutical Sciences Research 2013: 4(8): 3073-3079.
Ramya Krishna J, Naga B. Development and Validation of RP-HPLC method for the Simultaneous estimation of Ciprofloxacin and Ornidazole in Combined Pharmaceutical Dosage Form. J Advanced Pharma Technology. 2014;4(4):440-3.
Basci NE, Bozkurt A, Kalayci D, Kayaalp SO. Rapid liquid chromatographic assay of Ciprofloxacin in human aqueous humor. J Pharm and Biomed Anal. 1996;14(3):353- 6.
Toru Takahashi, Hitishi Hoshino, Takao yotsuyanagi. The use of water structure breakers, Urea and Guanidium chloride, New mobile phase modifiers in Reversed-Phase Partition High Performance Liquid Chromatography. Analytical Sciences. 2001; 17: 847-851.
Deepak Ghogare, Sheetal Patil. Hydrotropic Solubilisation: Tool for eco-friendly analysis. International Journal of Pharmacy and Pharmaceutical Research. 2018; 11(3): 300-322.
ICH. Q2A Validation of analytical procedure- Guidelines, Methodology, International Conference on Harmonization. Steering Committee, Geneva. 1994: 6-13.
Natarajan S. and Raman B. Development and validation of a stability indicating HPLC method for simultaneous estimation of ofloxacin and ornidazole. Indian Pharmacist. 2005; 4: 79-84.
Nagori B.P., Shrivastava B., Sharma V. and Rajput A. S. A validated spectrophotometric method for simultaneous estimation of ofloxacin and ornidazole in tablet dosage forms. J. Inst. Chem. (India). 2006; 78: 57-61.
Martindale: The Complete Drug Reference, 33rd edn., The Pharmaceutical Press, London, p. 599...
Ofloxacin-ornidazole[updated 2016: cited July 7]. available from http://www.medlineindia.com/antibiotic/ofloxacin_with_ornidazole.html, 2017.
http://en.wikipedia.org/wiki/Analytical_chemistry.
12 Gurdeep R. Chatwal, Sham K. Anand, Instrumental Method of Chemical Analysis, Himalaya Publishing House. 2002, Vol. 2, Page no. 40.12.
Hassan Mohammed., Spectrophotometric quantitation of Ornidazole and its formulations, pharmaceutical analysis, 1989, 22(2), 111-121.
Beckette A.H. and Stenlake J.B., Practical Pharmaceutical Chemistry, 4th edition, The Anthlone Press, London, 1988, 157, 281-307.
M. Somasekhar, J.V. Sagar, N. Narsaiah, R.A. Kumar and D.R. Krishna, Indian J. Pharm. Sci., 67, 302 (2005).
P.D. Sethi, HPTLC Quantitative Analysis of Pharmaceutical Formulations, edn. 1, pp. 1-68 (1996).
Sivasubramanian L, Muthukumaran A. RP-HPLC estimation of Gatifloxacin in Tablets. Indian J Pharm Sci 2005; 67:367-9.
Somashetkar M, Vidyasagar J, Narsaiah N, Anandkumar R, Krishna DR. Validated HPLC method for the determination of Ornidazole in Human serum and urine. Indian J Pharm Sci 2005; 67:302-6.
A.P. Sherje and K. J. Desai, Indian J Pharm Sci. 73(5)2011 579–582. Doi: 10.4103/0250-474X.99021.
V. M Gandhi, S. B. Nair, C. Menezes and R. Narayan, International Journal of Research in Pharmacy and Chemistry,, 3(1) 2013 6-11.
Text On Validation of Analytical Procedures, 1994, International Conference on Harmonization (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Steering Committee.
Manikanta AY, “Analytical Method Development and Validation for Simultaneous Estimation of Miconazole and Hydrocortisone in Topical Formulation by RP-HPLC” World j. pharm. Sci., 2015; 4(8): 2063-2080.
Meshram DB, Bagade SB, Tajnr MR, “Simultaneous Determination of Metronidazole and Miconazole Nitrate in Gel By HPTLC” Pak. J. pharm. Sci., 2009; 22(3): 323-328.
Shah KA, Dave JB.” Development and Validation of RP-HPLC And Hptlc Methods for Simultaneous Estimation of Mometason Furoate and Miconazole Nitrate in Cream Formulation” World j. pharm. And Pharm. Sci., 2015; 4(6): 1156-1172.
Indian Pharmacopoeia, The Indian Pharmacopoeia Commission Ghaziabad, 2010; III: 1823-1824.
Khattab FI, Ramadan NK, Hegazy MA, Ghoniem NS. Stability indicating methods for the determination of Ornidazole in the presence of its degradate according to ICH Guidelines. Pharm Anal Acta 3(179), 2012, 1-8.
R.K.Maheshwari, Asian J. Chem. 1(18), 2006, 393-396.
Pandya CD, Naik HS, Ghumare MP.Development and validation of RP-HPLC method for simultaneous estimation of ofloxacin and ornidazole with their related impurities in infusion dosage form.Inventi Rapid Pharm Analysis and Quality Assurance, 2014; 142- 155.
ICH, Impurities: Guidelines for residual Solvents, Q3C (R5). International Conference on Harmonization, Geneva. 2011.
List of impurities [updated cited September 11] available from http://www.vergoorganics.com, 2016.
Naik NC, Kumar R.Simultaneous determination of ofloxacin and ornidazole in tablets by spectrophotometry and reverse phase HPLC.Research journal of Pharmaceutical, Biological and Chemical, 2011; 693-708.
https://pubchem.ncbi.nlm.nih.gov/compound/Ornidazole.
O’Neil M J; The Merck Index, An Encyclopedia of Chemicals Drug and Biological; Doxycycline; Merck & Co. Inc; 14th Ed. 2006; 3474: 606.
Lila K N, Tapan K G; Spectrophotometric Method Development and Determination of Ornidazole in Bulk and Tablet Dosage Form. Int J Pharm Tech Res. 2011; 3(1):153-156.
http://www.genericpedia.com/generic/ornidazole/.
http://www.drugs.com/international/ornidazole.html.
http://www.medsafe.govt.nz/consumers/cmi/a/arrowornidazole.pdf.html.
ICH guidelines, Validation of analytical procedures: text and methodology, Q2A (R1) Nov; 2005.
M. Bakshi, B. Singh, A. Singh and S. Singh, J. Pharm. Biomed. Anal., 26, 891 (2001).
L. Mishra, Drugs Today, Lorina Publications, New Delhi, India, Issue 11, p. 375 (2003).
http://en.wikipedia.org/wiki/ornidazole/.
Tulasamma P., Govind V. and Venkateswarlu P., Spectrophotometric determination of ornidazole in pure and pharmaceutical formulations, Int. J. Pharm. Sci. Res., 2011, 2(1), 44-48.
Indian Pharmacopoeia (2010). 6th ed. Controller of Publication, Govt. of India, Ministry of Health and Family Welfare, New Delhi.
International Conference on Harmonization, (2005). Q2 (R1), Harmonised Tripartite Guidelines, Validation of Analytical Procedures: Text and Methodology, Geneva.
Nalini CN, Ramachandran S, Kavitha K and Harikrishna (2011). Simultaneous determination of Ofloxacin and Ornidazole in tablets by Spectrophotometry and RP-HPLC. Res J Pharm Biol Chem Sci 2: 693-708.
Rege PV and Ramesh M (2011). Simultaneous quantification of Ofloxacin and Ornidazole from combined pharmaceutical drug formulation by HPLC. Int J Pharm Bio Sci 2: 51-8.
Krishnaiah, Y.S.R., Indira Muzib, Y., Srinivasa Rao, G., Bhaskar, P. and Satyanarayana, V. (2003e) "Studies on the development of colon targeted oral drug delivery systems for ornidazole in the treatment of amoebiasis", Drug delitv 10, 111-117.
Rama Prasad, Y.V., Krishnaiah, Y.S.R. and Satyanarayana, S. (1998) "In vitro evaluation of guar gum as a carrier for colon-specific drug delivery", J. Control. Release 5l, 281-287.
Snyder.R, J. Kirkland, L. Glajch, Practical HPLC method development, 1997, II edition, A Wiley International publication, Pg: 235, 266-268, 351-353, 653-600, 686-695.
Development and Validation for Bosentan in Pharmaceutical formulations JOTCSA. 2022; 9(2):505-512.
Shahul HM, Jat RK, Indulatha VN. Method development and its validation for quantitative determination of bosentan in tablet dosage form by RP-HPLC. J Drug Delivery Ther.2017 Mar 15; 7(2):85–95.
R.K.Maheshwari, Indian Drugs, 43(8): 683-685, (2006).
R. K.Maheshwari, The Indian Pharmacist, (VI) 64: 67-69, (2007).
N. K. Jain, V. V. Patel, Hydrotropic solubilization, The Eastern Pharmacist, 29:51-54 (1986).
V. G. Gaikar, V. Latha, Hydrotropic properties of sodium salt of ibuprofen, Drug Development and Industrial Pharmacy, (23)3: 309-312 (1997)
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
