The Impact of Diabetes on Erectile Dysfunction: Pathophysiology and Management Strategies
DOI:
https://doi.org/10.63682/jns.v14i5S.7437Keywords:
This chapter discusses diabetes, erectile dysfunction, the processes involved and options for careAbstract
Background:Having diabetes mellitus seriously increases the risk for erectile dysfunction (ED) in men. Locally raised blood sugar levels over a long period are responsible for losing nerve function in the penis and hormone imbalance which eventually lead to ED. Analyzing this relationship helps doctors work better with diabetic patients.
Objectives:We need to look at the rates, key functions behind and proven effects of current therapies for erectile dysfunction in men with diabetes.
Study design: A prospective study.
Place and duration of study: Department of Urology Niazi Medical College Sargodha from jan 2022 to jan 2023
Methods:The study used a prospective protocol to look at 100 men with diabetes who were experiencing ED in Department of Urology Niazi Medical College Sargodha from jan 2022 to jan 2023. During evaluation, a history was taken, a physical examination was carried out and tests for fasting glucose, HbA1c and serum testosterone were made. The performance of erectile function was evaluated using the IIEF questionnaire. All data analysis was performed in SPSS version 25 and only results with p<0.05 were considered significant.
Results:100 patients whose average age was 54.2 years with a range of 9.1 years. Patients had been living with diabetes for about 8.5 years on average. Of those who took part, 72% had moderate or severe erectile dysfunction. Poor glycemic control (HbA1c level higher than 7.5%) was strongly related to the seriousness of ED (p=0.003). Severe ED was associated with lower testosterone levels (mean 280 ng/dL) compared to those with mild ED (mean 410 ng/dL), p=0.01.
Conclusion:The risk of erectile dysfunction is much higher for diabetics, linked to less-than-ideal control of blood sugar and low testosterone. Right away, doctors should use a complete treatment plan that includes choosing the right dose of sugars, hormonal therapy and PDE5 inhibitors to improve both sex life and quality of life for men with diabetes..
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Benin AE, Anura F, Idris RI, Inni SO. Erectile Dysfunction in Men with Diabetes: Pathophysiology and Treatment Approaches. Journal of Applied Sciences and Environmental Management. 2024 Jun 21;28(6):1719-27.
Sangiorgi G, Ceredo A, Benedetto D, Bonanni M, Chirico G, Cota L, Martuscelli E, Greco F. Anatomy, pathophysiology, molecular mechanisms, and clinical management of erectile dysfunction in patients affected by coronary artery disease: a review. Biomedicines. 2021 Apr 16;9(4):432.
Defends G, Mazzilli R, Tenuta M, Rossini G, Zampone V, Olana S, Faggiano A, Pozzuoli P, Isidora AM, Giannarelli D. Erectile dysfunction and diabetes: A melting pot of circumstances and treatments. Diabetes/metabolism research and reviews. 2022 Feb;38(2):e3494.
Desai A, Chen R, Cayetano A, Jayasena CN, Minhas S. Understanding and treating ejaculatory dysfunction in men with diabetes mellitus. Andrology. 2023 Feb;11(2):379-98.
Kaltsas A, Dimopoulos A, Dimitriadis F, Shashi D, Politis M, Mustakim E, Symeonidis EN, Christofis M, Solicits N, Zachariou A. Oxidative stress and Erectile Dysfunction: pathophysiology, impacts, and potential treatments. Current Issues in Molecular Biology. 2024 Aug 14;46(8):8807-34.
Dimidiate D, Weili A, Tuerxunmaimaiti A, Tao L, Zabiullah A, Radiate M. Risk factors for erectile dysfunction in diabetes mellitus: a systematic review and meta-analysis. Frontiers in Endocrinology. 2024 Apr 4; 15:1368079.
Mazzilli R, Zampone V, Olana S, Mirkovic N, Cimadomo D, Defends G, Faggiano A. Erectile dysfunction as a marker of endocrine and glycemic disorders. Journal of Endocrinological Investigation. 2022 Aug;45(8):1527-34.
Mostafa T, Abdel-Hamid IA. Ejaculatory dysfunction in men with diabetes mellitus. World journal of diabetes. 2021 Jul 15;12(7):954.
Cayetano‐Alcaraz AA, Tharakan T, Chen R, Solicits N, Minhas S. The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors. Andrology. 2023 Feb;11(2):257-69.
Signorelli A, Genchi VA, D’Oria R, Giordano F, Caruso I, Perrini S, Novaliches A, Laviola L, Giorgino F. Role of glucose-lowering medications in erectile dysfunction. Journal of clinical medicine. 2021 Jun 5;10(11):2501.
Sohail S, Ahmed A, Tanveer HU. Hollow fiber membrane for filtration of liquids. US Patent 11,148,100. October 19, 2021.Sohail S, Ahmed A, Tanveer HU. Hollow fiber membrane for filtration of liquids. US Patent 11,148,100. October 19, 2021. Available from: https://patents.google.com/patent/US11148100B2
Faheem HH, Tanveer HU, Abbas SZ, Maqbool F. Comparative study of conventional steam-methane-reforming (SMR) and auto-thermal-reforming (ATR) with their hybrid sorption enhanced (SE-SMR & SE-ATR) and environmentally benign process models for the hydrogen production. Fuel. 2021; 297:120769. doi: 10.1016/j.fuel.2021.120769
Sohail S, Ahmed A, Tanveer HU. Hollow fiber membrane for filtration of liquids. GB Patent GB2,573,404 B. November 6, 2019.
Sohail S, Ahmed A, Tanveer HU. Hohlfasermembran zur Filtration von Flüssigkeiten. EP Patent EP3,563,928. May 7, 2023.
Tanveer HU, Rai RA, Aslam RF, Muneeb Farrukh MH, Malik U. Impact of contaminated water on the prevalence of diarrheal diseases in children. Front Health Inform. 2024;13(8).
Argiolas A, Argiolas FM, Argiolas G, Melis MR. Erectile dysfunction: treatments, advances and new therapeutic strategies. Brain sciences. 2023 May 15;13(5):802.
Blair Y, Wessells H, Pop-Bosiu R, Ang L, Sarma AV. Urologic complications in diabetes. Journal of Diabetes and its Complications. 2022 Oct 1;36(10):108288.
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