Chitosan-Modified SLNs for Enhanced Colonic Delivery of Mesalamine: Formulation and Statistical Optimization
Keywords:
Mesalamine, colon delivery, optimization, solid lipid nanoparticles, chitosan, ulcerative colitisAbstract
The goal of the current study was to create and assess solid lipid nanoparticles coated with polysaccharides for the targeted delivery of Mesalamine, a medication used to treat Ulcerative colitis, a chronic inflammatory bowel disease. Three independent formulation variables—glyceryl monostearate content (X1), Chitosan concentration (X2), and Poloxamer concentration (X₃)—were optimized, and their effects on entrapment efficiency, particle size and drug release in colonic medium were assessed using a factorial design. Solid lipid nanoparticles were prepared by ultrasonication and hot homogenization. The optimized solid lipid nanoparticles F7 had a particle size of 100.1 nm, an entrapment efficiency of 78.01 %, and a sustained drug release of less than 20% at acidic pH and 90.9% in colonic medium after 24 h. The findings demonstrated that the formulation F7 showed controlled drug release in the colon and has the potential to enhance the results of Ulcerative colitis treatment. This research highlights that SLNs with a polysaccharide coating may be useful for delivering medications to the colon. In addition to targeted drug delivery, this work lays the groundwork for future investigations into novel interaction strategies in the manufacturing of biopharmaceuticals.
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