Recent Advances In Oral Potentially Malignant Disorders: A Therapeutic Perspective From An Oral And Maxillofacial Clinician And Pathologist – A Systematic Review
Keywords:
Oral potentially malignant disorders, oral squamous cell carcinoma, viral infections, artificial intelligence, microenvironment, metabolomics, early detectionAbstract
Oral potentially malignant disorders (OPMDs) are recognized precursors to oral squamous cell carcinoma (OSCC) and pose a major diagnostic and therapeutic challenge. This systematic review critically synthesizes recent advances in the classification, diagnosis, molecular pathology, viral associations, and therapeutic management of OPMDs. Systematic literature review according to PRISMA guidelines selected 8 major studies between 2021 and 2025. Developing evidence from literature points toward the role of advanced classification systems, artificial intelligence-guided diagnostics, metabolomic profiling, microenvironmental modulation, and viral oncogenesis in enhancing early diagnosis and risk stratification. Challenges persist with standardization of diagnostic modalities, cross-population validation of biomarkers, and making new technologies universally accessible globally. An integrated multidisciplinary strategy that includes technological advancements and molecular understanding is needed to maximize preventive measures and minimize the global burden of oral cancer.
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Imbesi Bellantoni M, Picciolo G, Pirrotta I, Irrera N, Vaccaro M, Vaccaro F, Squadrito F, Pallio G. Oral Cavity Squamous Cell Carcinoma: An Update of the Pharmacological Treatment. Biomedicines. 2023 Apr 7;11(4):1112. doi: 10.3390/biomedicines11041112. PMID: 37189730; PMCID: PMC10135659.
Kumari P, Debta P, Dixit A. Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer. Front Pharmacol. 2022 Apr 20;13:825266. doi: 10.3389/fphar.2022.825266. PMID: 35517828; PMCID: PMC9065478.
Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, Sáez Barba M, de Pablo García-Cuenca A, Braña García I, Bossi P, Nuciforo P, Simonetti S. Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies. Cancers (Basel). 2021 Jul 23;13(15):3696. doi: 10.3390/cancers13153696. PMID: 34359597; PMCID: PMC8345150.
Sahoo RK, Sahoo KC, Dash GC, Kumar G, Baliarsingh SK, Panda B, Pati S. Diagnostic performance of artificial intelligence in detecting oral potentially malignant disorders and oral cancer using medical diagnostic imaging: a systematic review and meta-analysis. Front Oral Health. 2024 Nov 6;5:1494867. doi: 10.3389/froh.2024.1494867. PMID: 39568787; PMCID: PMC11576460.
Migliaro M, Massuh D, Infante MF, Brahm AM, San Martín MT, Ortuño D. Role of Epstein-Barr Virus and Human Papilloma Virus in the Development of Oropharyngeal Cancer: A Literature Review. Int J Dent. 2022 Jun 20;2022:3191569. doi: 10.1155/2022/3191569. PMID: 35769943; PMCID: PMC9236829.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71. PMID: 33782057; PMCID: PMC8005924.
Jayasinghe RD, Siriwardena BSMS. Clinical Aspects of Oral Cancer and Potentially Malignant Disorders with Special Relevance to South Asia. Ann Maxillofac Surg. 2024 Jul-Dec;14(2):128-136. doi: 10.4103/ams.ams_184_24. Epub 2025 Jan 9. PMID: 39957882; PMCID: PMC11828067.
Zahid KS, Hidayat W, Zakiawati D. Viral Involvement in Oral Potentially Malignant Disorders: A Scoping Review. Cancer Manag Res. 2025 Feb 18;17:309-330. doi: 10.2147/CMAR.S485418. PMID: 39990277; PMCID: PMC11846534.
Celentano A, Cirillo N. Diseases with oral malignant potential: Need for change to inform research, policy, and practice. J Oral Pathol Med. 2024; 53(8): 495-501. doi:10.1111/jop.13573
Mohd Faizal, N. F., Vincent-Chong, V. K., Ramanathan, A., Paterson, I. C., Karen-Ng, L. P., & Zaini, Z. M. (2024). Metabolomic Profiling of Oral Potentially Malignant Disorders and Its Clinical Values. Biomedicines, 12(12), 2899. https://doi.org/10.3390/biomedicines12122899
Vinayahalingam S, van Nistelrooij N, Rothweiler R, Tel A, Verhoeven T, Tröltzsch D, Kesting M, Bergé S, Xi T, Heiland M, Flügge T. Advancements in diagnosing oral potentially malignant disorders: leveraging Vision transformers for multi-class detection. Clin Oral Investig. 2024 Jun 8;28(7):364. doi: 10.1007/s00784-024-05762-8. PMID: 38849649; PMCID: PMC11161543.
Deng S, Wang S, Shi X, Zhou H. Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis. Int J Mol Sci. 2022 Aug 11;23(16):8940. doi: 10.3390/ijms23168940. PMID: 36012205; PMCID: PMC9409092.
Wang C, Qi X, Zhou X, Liu H, Li M. Diagnostic value of objective VELscope fluorescence methods in distinguishing oral cancer from oral potentially malignant disorders (OPMDs). Transl Cancer Res. 2022 Jun;11(6):1603-1615. doi: 10.21037/tcr-21-2804. PMID: 35836514; PMCID: PMC9273673.
Walsh T, Warnakulasuriya S, Lingen MW, Kerr AR, Ogden GR, Glenny A-M, Macey R. Clinical assessment for the detection of oral cavity cancer and potentially malignant disorders in apparently healthy adults. Cochrane Database of Systematic Reviews 2021, Issue 12. Art. No.: CD010173. DOI: 10.1002/14651858.CD010173.pub3.
Kumari P, Debta P and Dixit A (2022) Oral Potentially Malignant Disorders: Etiology, Pathogenesis, and Transformation Into Oral Cancer. Front. Pharmacol. 13:825266. doi: 10.3389/fphar.2022.825266
Chiu SF, Ho CH, Chen YC, Wu LW, Chen YL, Wu JH, Wu WS, Hung HK, Chiang WF. Malignant transformation of oral potentially malignant disorders in Taiwan: An observational nationwide population database study. Medicine (Baltimore). 2021 Mar 5;100(9):e24934. doi: 10.1097/MD.0000000000024934. PMID: 33655959; PMCID: PMC7939230.
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