Case Report On Goblet Cell Adenocarcinoma Of The Appendix: A Rarity

Authors

  • Vinisha Manikandan
  • Sriram. N
  • M. Dheenadhayalan
  • K. Karthickeyan
  • P. Shanmugasundaram
  • M.K.Sundar Sri

Keywords:

Goblet cell adenocarcinoma, Appendectomy, Right Hemicolectomy, Appendicitis

Abstract

The rare appendix tumour known as the goblet cell carcinoid (GCC) is distinct from adenocarcinoma and other carcinoid tumours. The most typical symptoms are appendicitis, abdominal distention, and chronic abdominal pain. In this view, we present a case of a 41-year- old male patient who came with a complaint of right lower abdominal pain. Ultrasound abdomen revealed acute appendicitis. A laparoscopic appendicectomy was performed. Histopathological examination reported an appendix showing carcinomatous changes, goblet cell adenocarcinoma low grade. The patient agreed to proceed with a right hemicolectomy, 2- 4 weeks after his appendectomy. Our goal was to increase public awareness of this rare condition and also emphasize how challenging it is to diagnose correctly.

Downloads

Download data is not yet available.

References

Palmer K, Weerasuriya S, Chandrakumaran K, Rous B, White BE, Paisey S, et al. Goblet cell adenocarcinoma of the appendix: A systematic review and incidence and survival of 1,225 cases from an English cancer registry. Front Oncol [Internet]. 2022;12:915028. Available from: http://dx.doi.org/10.3389/fonc.2022.915028

Gilmore G, Jensen K, Saligram S, Sachdev TP, Arekapudi SR. Goblet cell carcinoid of the appendix - diagnostic challenges and treatment updates: a case report and review of the literature. J Med Case Rep [Internet]. 2018;12(1):275. Available from: http://dx.doi.org/10.1186/s13256-018-1789-6

Sigley K, Franklin M, Welch S. Appendiceal goblet cell adenocarcinoma case report and review of the literature. Cureus [Internet]. 2021;13(2):e13511. Available from: http://dx.doi.org/10.7759/cureus.13511

Yano M, Katoh T, Hamaguchi T, Kozawa E, Hamada M, Nagata K, et al. Tumor-to-tumor metastasis from appendiceal adenocarcinoma to an ovarian mature teratoma, mimicking malignant transformation of a teratoma: a case report. Diagn Pathol [Internet]. 2019;14(1):88. Available from: http://dx.doi.org/10.1186/s13000-019-0865-6

Sinno SAJ, Jurdi NMH. Goblet cell tumors of the appendix: A review. Ann Diagn Pathol [Internet]. 2019;43(151401):151401. Available from: http://dx.doi.org/10.1016/j.anndiagpath.2019.151401

Zakka K, Williamson S, Jiang R, Reid MD, Alese OB, Shaib WL, et al. Is adjuvant chemotherapy beneficial for stage II-III goblet cell carcinoid/goblet cell adenocarcinoma of the appendix? Surg Oncol [Internet]. 2021;36:120–9. Available from: http://dx.doi.org/10.1016/j.suronc.2020.12.003

Onyemkpa C, Davis A, McLeod M, Oyasiji T. Typical carcinoids, goblet cell carcinoids, mixed adenoneuroendocrine carcinomas, neuroendocrine carcinomas and adenocarcinomas of the appendix: a comparative analysis of survival profile and predictors. J Gastrointest Oncol [Internet]. 2019;10(2):300–6. Available from: http://dx.doi.org/10.21037/jgo.2018.11.08

Zegarac M, Nikolic S, Kolarevic D, Kocic M, Djurisic I, Inic Z, et al. Goblet cell carcinoid of the appendix. Review of the literature a propos of a rare case of endometrial metastases. J BUON. 2018;23(4):867–71.

Fields AC, Lu P, Enzinger A, Goldberg J, Irani J, Bleday R, et al. Treatment patterns and outcomes in goblet cell carcinoid tumors of the appendix. J Surg Oncol [Internet]. 2019;120(7):1096–101. Available from: http://dx.doi.org/10.1002/jso.25723

Hosseini M, Ronquillo N. Goblet cell adenocarcinoma: concepts and updates. Diagn Histopathol (Oxf) [Internet]. 2021;27(2):69–74. Available from: http://dx.doi.org/10.1016/j.mpdhp.2020.11.003

Clift AK, Kornasiewicz O, Drymousis P, Faiz O, Wasan HS, Kinross JM, et al. Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management. Endocr Connect [Internet]. 2018;7(2):268–77. Available from: http://dx.doi.org/10.1530/ec-17-0311

Nonaka D, Papaxoinis G, Lamarca A, Fulford P, Valle J, Chakrabarty B. A study of appendiceal crypt cell adenocarcinoma (so-called goblet cell carcinoid and its related adenocarcinoma). Hum Pathol [Internet]. 2018;72:18–27. Available from: http://dx.doi.org/10.1016/j.humpath.2017.08.005

Zhang K, Meyerson C, Kassardjian A, Westbrook LM, Zheng W, Wang HL. Goblet cell carcinoid/carcinoma: An update: An update. Adv Anat Pathol [Internet]. 2019;26(2):75–83. Available from: http://dx.doi.org/10.1097/PAP.0000000000000222

Johncilla M, Stachler M, Misdraji J, Lisovsky M, Yozu M, Lindeman N, et al. Mutational landscape of goblet cell carcinoids and adenocarcinoma ex goblet cell carcinoids of the appendix is distinct from typical carcinoids and colorectal adenocarcinomas. Mod Pathol [Internet]. 2018;31(6):989–96. Available from: http://dx.doi.org/10.1038/s41379-018-0003-0

Livoff A, Asna N, Gallego-Colon E, Daum AZ, Harkovsky T, Schaffer M. Goblet cell carcinoid of the appendix: Two case reports and a review of the literature. Mol Clin Oncol [Internet]. 2019;11(5):493–7. Available from: http://dx.doi.org/10.3892/mco.2019.1921

Downloads

Published

2025-07-08

How to Cite

1.
Manikandan V, N S, Dheenadhayalan M, Karthickeyan K, Shanmugasundaram P, Sri M. Case Report On Goblet Cell Adenocarcinoma Of The Appendix: A Rarity. J Neonatal Surg [Internet]. 2025Jul.8 [cited 2025Oct.4];14(32S):4279-85. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8115

Most read articles by the same author(s)

1 2 3 > >>