Serum Zinc Levels In Simple Febrile Seizures – A Case Control Study
Keywords:
Febrile seizures, Serum zinc levels, Epileptics, Hypozincemia, Neuronal activityAbstract
Background: Febrile seizures are the most common type of seizures in childhood. Various theories have been put forward regarding the role of micro nutrients as risk factors for febrile seizures. The aim of the present study was to find out the association between serum zinc levels and simple febrile seizures in children aged between 6 months to 5 years.
Materials And Methods: This Hospital based case control study was conducted during June 2019 to June 2020 at Institute of child health & Research centre, Government Rajaji hospital, Madurai medical college, Madurai. The study population includes 70 children with simple febrile seizures and 70 children with fever without seizures as control. Serum zinc levels were measured in two groups by colorimetric method.
Results: Serum zinc level was low in 60 % (n=42) of children with simple febrile seizures and 24.28 % (n=17) of children with fever without seizures though there was no statistical significant difference in distribution of age, sex, temperature, consanguinity & nutritional status (according to IAP grading) between two groups. Mean serum zinc was 57.96 mcg/dl among cases and 84.86 mcg/dl among controls. Hence serum zinc levels were significantly low in Children with simple febrile seizures compared to fever without seizures (p < 0.001) in our study. Also, Majority of children with prolonged febrile seizures had low serum zinc levels.
Conclusion: This study establishes a significant relationship between low serum zinc levels and simple febrile seizures thereby substantiating Hypozincemia was one of the predisposing factors in simple febrile seizures.
Downloads
References
Kliegman, Stanton, St Geme, Schor.Nelson textbook of pediatrics21st Edition 20th edition pg:2829-2831.
National Institute of Health. Febrile seizures: long termmanagement of children with fever associated seizures.Pediatrics. 1980;66;1009-1012.
Guidelines for epidemiologic studies on epilepsy. Commission on Epidemiology and prognosis, International league against Epilepsy. Epilepsia. 1993;34:592-596
Guidelines for evaluating simple febrile seizures in children, American academy of pediatrics.2011 jun 1;83(11):1348-1350
Piyush Gupta, PSN Menon, Siddarth Ramji, Rakesh Lodha. PG Text book of pediatrics 2nd Edition pg1013-1017
Cuevas LE, Koyanagi A. Zinc and infection: a review. Ann Trop Paediatr. 2005;25:149–160
Mahyar A, Pahlavan A, Varasteh Nijad A. Serum zinc level in children with febrile seizure. Acta Medica Iranica 2008;46(6):67
Ganesh R, Janakiraman L. Serum Zinc levels in children with simple febrile seizure. Clin Pediatr (Phila) 2008;47(2):164-6.
Heydarian F, Ghasemian A. Serum zinc level in patients with Simple Febrile seizure. Iran J Child Neurology 2010;4(2):41-4 Zinc deficiency as a risk factor for febrile seizures- Palliana, DK Sinh.
Margaretha L, masloman N. Correlation between serum zinc level and simple febrile seizure in children. Paediatricindones. 2010;50(6):326-330.
Talebian A, Vakili Z. Talar SA, Kazerni M. Mousavi GA. Assessment of the relation between serum Zinc and magnesium levels in children with febrile convulsion. Iranian Journal of Pathology 2009;4:157-60.
Gunduz Z, Yavuz I, Koparal M, Kurnanda S. Serum and cerebrospinal fluidzinc levels in children with febrile convulsions.1996:38(3):273-41
Vidhyasagar V et al., Sch. J. App. Med. Sci., September 2015; 3(6A): 2210-2219 Febrile convulsions- a study. Saidulhaque. Pakistan Pediatric Journal.
Kumari PL, Nair MK, Nair SM, Kailas L, Geetha S. Irondeficiency as a risk factor for simple febrile seizures - a case control study. Indian Pediatr 2011; 49(1):17-9.
Karthikeyan P, Prasanna R, Sathyamoorthy M, Reddy SM, Sekar P. Serum zinc levels in children with simple febrile seizures. Int J ContempPediatr 2015; 2:424-7.
Offringa M, Lubsen J, Nelson KB et al Risk factors for seizure recurrence in children with febrile seizures: a pooled analysis fromfive studies J. Pediatric April 1994; 124(4):574-84
Retrospective study of 160 children with febrile convulsions – Plochl E,Laubichler W , KlinPediatr 1992;204(1);Pg 16 -20
Vidhyasagar V et al., Sch. J. App. Med. Sci., September 2015;3(6A): 2210-2219 Febrile convulsions- a study. Saidulhaque. Pakistan Pediatric Journal
Sadlier LG, Scheffer IE. Febrile seizures BMJ. 2007;334:307-11
Berg AT, Shinner S. unprovoked seizures in children with febrile seizures: short term outcome. Neurology. 1996;47:562-8
Sampath kumar P et al. Int J contemp Pediatr.2018 May:5(3): 977-982
Okposio Matthias M, Wilson Sadoh, Gabriel Ofovwe, Alphonsus Onyiriuka. Serum Zinc level in Nigerian children with febrile convulsion. Journal of Pediatric Neurology 2012;10 (3):187-193.
Gatoo et al. correlation of serum zinc level with simple febrile seizures: A Hospital Based Prospective Case Control study. Int Jpediatr, Vol.3, N2-2, Serial No.16, April 2015.
Burhangnoglu M, Tutuncuoglu 5, Coker C, Tekgul H, Ozgur T. Hypozincemia in febrile convulsion.Eur J pediatr 1996;155(6);498-501
Tulip group.com: colorimetric assessment of zinc in serum and Urine by nitro PAPS method; ZNC(Col):01(p).
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
