Design, Synthesis, Characterization and Biological Evaluation Of 2, 4, 5-Trisubstituted Imidazole Derivatives As Potent Antimicrobial Agents
Keywords:
Molecular docking, 2,4,5 -triphenyleimidazole, Antimicrobial activityAbstract
Imidazole derivatives are thought to be promising chemical substances that may have therapeutic efficacy against a number of dangerous pathogenic microorganisms. Molecular docking is an effective method in modern drug design to have greater comprehension of computational binding. New imidazole derivatives were designed for this investigation. Out of the designed compounds two derivatives, N1 (naphthalen-1-yl)-4,5-diphenyl-1H-imidazole) & N2 (2-(2-methylenaphthalen-1-yl)-4,5-diphenyl-1H-imidazole), exhibit good affinity for the active pocket of glucosamine-6-phosphate synthase (ID2VF5), according to the molecular docking studies. The compounds with a high binding affinity were synthesized by using a condensation reaction in the presence of a catalyst. IR and 1H NMR were used to confirm the synthesized compound's structure. By employing the cup & plate procedure, it was found that the synthesized imidazole derivatives exhibited antimicrobial activity toward both the Gram-positive organism Staphylococcus aureus and the Gram-negative organism Escherichia coli
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References
Abd-Alaziz, A.M., (2024), Synthesis, characterization, and bioactivity evaluation for some metal ions complexes with new ligand derived from 2-hydroxy-1-napthaldehyde. Baghdad Sci. J., 21, 1220-1233.
Ai, J.; Yang, L.; Tian, Z.Z., (2023), Cobalt(II) and nickel(II) complexes based on 2,5-di(pyridine-4 yl)thiazolo[5,4-d]thiazole and dicarboxylate ligands: Synthesis, structures and properties. Z. Naturforsch. B, 78, 331-337.
Murali A., & Shaji A., (2019), synthesis, characterization, and evaluation of antibacterial and antidepressant activities of novel tetrasubstituted imidazole derivatives. Asian Journal Of Pharmaceutical And Clinical Research, 12(10), 93–97.
Ali, I., Lone, M. N., & Aboul-Enein, H. Y. (2017). Imidazoles as potential anticancer agents. MedChemComm, 8(9), 1742–1773.
Burungale D. S, and M. J. Bhitre, (2013), synthesis of 2, 4, 5- triphenyl imidazole derivatives and biological evaluation for their antibacterial and anti-inflammatory activity, International Journal of Pharmaceutical Sciences and Research, 4(10): 4051-4057
Chmara, H., Andruszkiewicz, R., Borowski, E., (1984), Inactivation of glucosamine-6-phosphatesynthetase from Salmonella typhimurium LT2 SL 1027 by N-beta-fumarylcarboxyamido-l-2,3-diamino-propionic acid. Biochem. Biophys. Res. Commun. 120, 865–87
Gaba, M., Mohan, C., (2016), Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions. Med Chem Res , 25, 173–210
Husain, Asif et al., (2013), Synthesis and biological evaluation of di- and tri-substituted imidazoles as safer anti-inflammatory-antifungal agents. Journal of Pharmacy and Bioallied Sciences 5(2):p 154-161,
Kondaparla S., et al.,(2018), Design, synthesis and antiplasmodial activity of novel imidazole derivatives based on 7-chloro-4-aminoquinoline,Bioorganic Chemistry,Volume 80, 204-211,
Milewski, S, et al., (1986), Antibiotic tetaine- a selective inhibitor of chitin and mannoprotein biosynthesis in Candida albicans. Arch. Microbiol, 145, 234–240
Sallal A.H. Abdullah and Shia J S,(2024), synthesis of some metal ion complexes of new imidazole derivative, characterization, and biological activity, Bull. Chemical Society of Ethiopia, 38(6), 1681-1690.
Sharma D., , et al., (2009), Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives, European Journal of Medicinal Chemistry, 44 (6),2347-2353,
Verma et al.,(2017), Synthesis of new Imidazole Derivatives as effective Antimicrobial Agents, Indian Journal of Pharmaceutical and Biological Research (IJPBR), 5(1):1-9
Vijesh A. M., et al., (2011), “Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives,” European Journal of Medicinal Chemistry, vol. 46, no. 8, pp. 3531–3536.
Vijesh A.M., et al., (2013), Molecular docking studies of some new imidazole derivatives for antimicrobial properties. Arabian J Chem, 6:197–204.
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