Comparative Analysis of Piper longum and Withania somnifera in Alleviating Depression
Keywords:
Piper longum, Withania somnifera, depression, antidepressant, phytotherapyAbstract
Depression represents a significant global health challenge, prompting extensive research into natural therapeutic alternatives. This comparative study investigates the antidepressant efficacy of Piper longum (long pepper) and Withania somnifera (ashwagandha) through systematic analysis of their bioactive compounds, mechanisms of action, and clinical outcomes. The research methodology employed a comprehensive literature review, meta-analysis of clinical trials, and comparative assessment of pharmacological properties. The hypothesis posited that both plants demonstrate significant antidepressant properties, with Withania somnifera showing superior clinical efficacy compared to Piper longum. Results indicated that piperine from Piper longum exhibits monoamine oxidase inhibitory activity, while withanolides from Withania somnifera demonstrate broader neurotransmitter modulation effects. Clinical studies revealed that Withania somnifera extract (500-1000mg daily) produced significant improvements in depression scores compared to placebo, while Piper longum showed promising preclinical results but limited clinical validation. The discussion highlights the complementary mechanisms of both plants, with Withania somnifera demonstrating superior evidence-based therapeutic potential for depression management. In conclusion, while both plants possess antidepressant properties, Withania somnifera presents stronger clinical evidence and broader therapeutic applicability for depression treatment.
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Abdel-Magied, E. M., Abdel-Rahman, H. A., & Harraz, F. M. (2001). The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. Journal of Ethnopharmacology, 75(1), 1-4.
Durg, S., Bavage, S., & Shivaram, S. B. (2020). Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Phytotherapy Research, 34(5), 1041-1059.
Emon, N. U., Jahan, I., Sayeed, M. A., Aktar, S., Islam, M. N., Ahmed, S., ... & Rahmatullah, M. (2021). Antidepressant, anxiolytic, antipyretic, and thrombolytic profiling of methanol extract of the aerial part of Piper nigrum: In vivo, in vitro, and in silico approaches. Food Science & Nutrition, 9(4), 2034-2054.
Gopukumar, K., Thanawala, S., Somepalli, V., Rao, T. S. S., Thamatam, V. B., & Chauhan, S. (2023). A standardized Withania somnifera (Linn.) root extract with piperine alleviates the symptoms of anxiety and depression by increasing serotonin levels: A double-blind, randomized, placebo-controlled study. Journal of Integrative and Complementary Medicine, 29(10), 586-598.
Lee, S. A., Hong, S. S., Han, X. H., Hwang, J. S., Oh, G. J., Lee, K. S., ... & Ro, J. S. (2005). Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Chemical and Pharmaceutical Bulletin, 53(7), 832-835.
Pratte, M. A., Nanavati, K. B., Young, V., & Morley, C. P. (2014). An alternative treatment for anxiety: A systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). Journal of Alternative and Complementary Medicine, 20(12), 901-908.
Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2022). An overview on ashwagandha: A Rasayana (rejuvenator) of Ayurveda. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S), 208-213.
Abdel-Magied, E. M., Abdel-Rahman, H. A., & Harraz, F. M. (2001). The effect of aqueous extracts of Cynomorium coccineum and Withania somnifera on testicular development in immature Wistar rats. Journal of Ethnopharmacology, 75(1), 1-4.
Andallu, B., & Radhika, B. (2000). Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Indian Journal of Experimental Biology, 38(6), 607-609.
Archana, R., & Namasivayam, A. (1999). Antistressor effect of Withania somnifera. Journal of Ethnopharmacology, 64(1), 91-93.
Auddy, B., Hazra, J., Mitra, A., Abedon, B., & Ghosal, S. (2008). A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. JANA, 11(1), 50-56.
Bhattacharya, S. K., Bhattacharya, A., Sairam, K., & Ghosal, S. (2000). Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine, 7(6), 463-469.
Chandrasekhar, K., Kapoor, J., & Anishetty, S. (2012). A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian Journal of Medical Research, 136(1), 37-45.
Cooley, K., Szczurko, O., Perri, D., Mills, E. J., Bernhardt, B., Zhou, Q., & Seely, D. (2009). Naturopathic care for anxiety: A randomized controlled trial ISRCTN78958974. PLoS One, 4(8), e6628.
Davis, L., & Kuttan, G. (2000). Immunomodulatory activity of Withania somnifera. Journal of Ethnopharmacology, 71(1-2), 193-200.
Gupta, G. L., & Rana, A. C. (2007). Withania somnifera (ashwagandha): A review. Pharmacognosy Reviews, 1(1), 129-136.
Kulkarni, R. R., Patki, P. S., Jog, V. P., Gandage, S. G., & Patwardhan, B. (1991). Treatment of osteoarthritis with a herbomineral formulation: A double-blind, placebo-controlled, cross-over study. Journal of Ethnopharmacology, 33(1-2), 91-95.
Mishra, L. C., Singh, B. B., & Dagenais, S. (2000). Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): A review. Alternative Medicine Review, 5(4), 334-346.
Naidu, P. S., Singh, A., Kulkarni, S. K., & Kaul, P. N. (2003). Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: Possible role of striatal dopamine. Phytotherapy Research, 17(9), 1039-1042.
Raut, A. A., Rege, N. N., Tadvi, F. M., Solanki, P. V., Kene, K. R., Shirolkar, S. G., ... & Vaidya, A. B. (2012). Exploratory study to evaluate tolerability, safety, and activity of ashwagandha (Withania somnifera) in healthy volunteers. Journal of Ayurveda and Integrative Medicine, 3(3), 111-114.
Sehgal, V. N., Verma, P., Khurana, A., Dwivedi, S., Verma, S., Nayak, C. R., ... & Mahajan, R. (2012). Evaluation of antidepressant activity of Withania somnifera Dunal (winter cherry): A Rasayana of Ayurveda in albino rats. Advances in Life Sciences, 2(1), 15-20
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