Harnessing Corn Silk Syrup For Liver And Kidney Health: A Natural Cure
Keywords:
Corn silk syrup, Corn silk syrup, Hepatoprotective, Hepatoprotective, Nephroprotective, Nephroprotective, Antioxidant activity, Antioxidant activity, Phytochemicals, PhytochemicalsAbstract
Traditional herbal remedy Zea mays L. (commonly known as corn silk) is now scientifically proven to benefit liver and kidney health. This analysis investigates both the chemical identities present in corn silk syrup and its clinical effects together with its multiple therapeutic usage possibilities as an eco-friendly natural medicine. The bioactive contents in corn silk include flavonoids, saponins, alkaloids, phenolic compounds that generate its strong hepatoprotective along with anti-inflammatory and diuretic effects and antioxidant potential. These properties make corn silk particularly promising in managing renal and hepatic disorders such as nephrotoxicity, kidney stones, and liver fibrosis. Preclinical and limited clinical studies suggest that corn silk syrup may reduce elevated serum creatinine and urea levels, enhance urine output, and protect against drug- or toxin-induced hepatic damage. Its antioxidant activity contributes to the reduction of oxidative stress and liver and kidney tissue lipid peroxidative damage. In addition, the preparation of the syrup using green and simple extraction techniques underpins its incorporation into functional food and nutriticum capsules. Further standardization of dosage, long-term evaluation of safety, and clinical trials are needed to confirm its efficacy and optimize its use. This review brings the potential of the use of corn silk syrup as a cheap, natural alternative or addendum to the liver and kidney health management process
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Colombo, R.; Ferron, L.; Papetti, A. Colored corn: An Up-Date on metabolites extraction, health implication, and potential use. Molecules 2021, 26, 199.
Ikpeazu, V.O.; Ugbogu, E.A.; Emmanuel, O.; Uche-Ikonne, C.; Okoro, B.; Nnaemeka, J. Evaluation of the safety of oral intake of aqueous extract of Stigma maydis (corn silk) in rats. Acta Sci. Pol. Technol. Aliment. 2018, 17, 387–397.
M.A. Ebrahimzadeh, F. Pourmorad, S. Hafe, Antioxidant activities of Iranian corn silk, Turk. J. Biol. 32 (2008) 43–49.
Kaur P, Singh J, Kaur M, Rasane P, Kaur S, Kaur J, et al. Corn silk as an agricultural waste: A comprehensive review on its nutritional composition and bioactive potential. Waste Biomass Valoriz. 2023 May;14(5):1413–32. doi: 10.3390/agronomy12040777.
Al-Janabi AS, Khadim OM. Mouth gargles and antimicrobial activ ities of extracts of corn silk. Int J Drug Deliv Technol. 2022;12(3):1025–7.
Shi S, Li S, Li W, Xu H. Corn silk tea for hypertension: a systematic review and meta-analysis of randomized controlled trials. Evidence-Based Complementary Altern Med. 2019 Jan; 2019:2915498. doi: 10.1155/2019/2915498.
Shirkav, A. and Nazif, H. R. (2019) “Numerical Study on the Effects of Blood Perfusion and Body Metabolism on the Temperature Profile of Human Forearm in Hyperthermia Conditions,” Journal of Thermal Biology. 84:339 350.
Wang, C., Zhang, T., Liu, J., Lu, S., Zhang, C., Wang, E., et al. (2011). Subchronic Toxicity Study of Corn silk with Rats. Journal of Ethnopharmacology. 137:36-43.
Shirkav, A. and Nazif, H. R. (2019) “Numerical Study on the Effects of Blood Perfusion and Body Metabolism on the Temperature Profile of Human Forearm in Hyperthermia Conditions,” Journal of Thermal Biology. 84:339 350.
Deokar, A.M.; Deokar, G.S. and Kshirsagar, S.J.; Corn silk (Stigma Maydis) as a herbal remedie: an overview. International Journal of Institutional Pharmacy and Life sciences. 2016, 6(3): 2249-6807.
Choi, D.J.; et al.; Neuroprotective effects of corn silk maysin via inhibition of H2O2-induced apoptotic cell death in SK-N MC cells. Life sciences.2014, 109.
Hasanudin, K.; Hashim, P. and Mustafa, S.; Corn silk (Stigma Maydis) in healthcare: A phytochemical and pharmacological review. Molecules. 2012, 17: 9697-9715
Sepehri, G., Derakhshanfar, A., Zade, F. Y. (2011). Protective Effects of Corn silk Extract Administration on Gentamicin-induced Nephrotoxicity in Rats. Comp. Clin. Pathol., 20:89–94.
Morshed S, Islam SM. Antimicrobial activity and phytochemical properties of corn (Zea mays L.) silk. SKUAST J Res. 2015;17(1):8–14.
Emmanuel SA, Olajide O, Abubakar S, Akiode SO, Etuk-Udo G. Chemical evaluation, free radical scavenging activities and antimi crobial evaluation of the methanolic extracts of corn silk (Zea mays. J Adv Med Pharm Sci. 2016 Jan;9(4):1–8. doi: 10.9734/JAMPS/2016/ 28530.
Solihah MA, Rosli WW, Nurhanan AR. Phytochemicals screening and total phenolic content of Malaysian Zea mays hair extracts. Int Food Res J. 2012 Oct;19(4):1533.
Sarepoua E, Tangwongchai R, Suriharn B, Lertrat K. Influence of variety and harvest maturity on phytochemical content in corn silk. Food Chem. 2015 Feb;169:424–9. doi: 10.1016/j.foodchem.2014. 07.136.
Limmatvapirat C, Nateesathittarn C, Dechasathian K, Moohummad T, Chinajitphan P, Limmatvapirat S. Phytochemical analysis of baby corn silk extracts. J Ayurveda Integr Med. 2020 Jul;11(3):344–51. doi: 10.1016/j.jaim.2019.10.005.
Nawaz H, Aslam M, Muntaha ST. Effect of solvent polarity and extraction method on phytochemical composition and antioxidant potential of corn silk. Free Radic Antioxid. 2019 Apr;9(1):5–11. doi: 10.5530/fra.2019.1.2.
Žilić S, Janković M, Basić Z, Vančetović J, Maksimović V. Antioxidant activity, phenolic profile, chlorophyll and mineral matter content of corn silk (Zea mays L): Comparison with medicinal herbs. J Cereal Sci. 2016 May;69:363–70. doi: 10.1016/j.jcs.2016.05.003
Ammor K, Amarti FE, Lagzizir R, Mahjoubi F, Bousta D, Chaqroune A. Study of antioxidant, anti-inflammatory, antinoci ceptive activities and toxicity of stigmata of zea mays extracts. Phytothérapie. 2021 Aug;19(4):216. doi: 10.3166/phyto-2019-0209.
Azevedo AS, Seibert JB, Amparo TR, Antunes AD, Sousa LR, Souza GH, et al. Chemical constituents, antioxidant potential, antibacterial study and photoprotective activity of Brazilian corn silk extract. Food Sci Technol. 2022 Aug;42:e98421. doi: 10.1590/fst.98421.
da Hora NR, Santana LF, da Silva VD, Costa SL, Zambotti-Villela L, Colepicolo P, et al. Identification of bioactive metabolites from corn silk extracts by a combination of metabolite profiling, univariate statistical analysis and chemometrics. Food Chem. 2021 Dec;365:130479. doi: 10.1016/j.foodchem.2021.130479.
Mulat M, Khan F, Muluneh G, Pandita A. Phytochemical profile and antimicrobial effects of different medicinal plant: current knowl edge and future perspectives. Curr Tradit Med. 2020 Mar;6(1):24–42. doi: 10.2174/2215083805666190730151118.
Logan-del Castillo EJ, Azares GF, Almonte CJ, Pascua KM, Santiago IB, So EG, et al. Effects of incorporation of microwave: Dried corn silk (Stigma maydis) powder on the quality and stability of Beef Patties. In Journal of Physics: Conference Series. Vol. 1529, Issue 3, IOP Publishing; 2020 Apr. p. 032064. doi: 10.1088/1742 6596/1529/3/032064.
Nawaz H, Aslam M, Muntaha ST. Effect of solvent polarity and extraction method on phytochemical composition and antioxidant potential of corn silk. Free Radic Antioxid. 2019 Apr;9(1):5–11. doi: 10.5530/fra.2019.1.2.
Emmanuel SA, Olajide O, Abubakar S, Akiode SO, Etuk-Udo G. Chemical evaluation, free radical scavenging activities and antimi crobial evaluation of the methanolic extracts of corn silk (Zea mays. J Adv Med Pharm Sci. 2016 Jan;9(4):1–8. doi: 10.9734/JAMPS/2016/ 28530.
Emmanuel SA, Olajide O, Abubakar S, Akiode SO, Etuk-Udo G. Chemical evaluation, free radical scavenging activities and antimi crobial evaluation of the methanolic extracts of corn silk (Zea mays. J Adv Med Pharm Sci. 2016 Jan;9(4):1–8. doi: 10.9734/JAMPS/2016/ 28530.
Solihah MA, Rosli WW, Nurhanan AR. Phytochemicals screening and total phenolic content of Malaysian Zea mays hair extracts. Int Food Res J. 2012 Oct;19(4):1533
Hashim, P. Centella asiatica in food and beverage applications and its potential antioxidant and neuroprotective effect. J. Int. Food Res. 2011, 18, 2217–2222
Vladimir-Knežević, S.; Blažeković, B.; Štefan, M.B.; Alegro, A.; Kőszegi, T.; Petrik, J. Antioxidant activities and polyphenolic contents of three selected micromeria species from croatia. Molecules 2011, 16, 1454–1470.
Zhu, K.X.; Lian, C.X.; Guo, X.N.; Peng, W.; Zhou, H.M. Antioxidant activities and total phenolic contents of various extracts from defatted wheat germ. Food Chem. 2011, 126, 1122–1126.
Liu, J.; Wang, C.; Wang, Z.; Zhang, C.; Lu, S.; Liu, J. The antioxidant and free-radical scavenging activities of extract and fractions from corn silk (Zea mays L.) and related flavone glycosides. Food Chem. 2011, 126, 261–269.
Hassas-Roudsari, M.; Chang, P.R.; Pegg, R.B.; Tyler, R.T. Antioxidant capacity of bioactive extracted from canola meal by subcritical water, ethanolic and hot water extraction. Food Chem. 2009, 114, 717–726.
Kaur, D., Kaur, D., Bains, N.A., Chopra, A.N., Arora, P.O.: Anti anxiety evaluation of extracts of stigma maydis (corn silk). Int. J. Pharm. Pharm. Sci. 8, 309–312 (2015).
Amjad, A., Rizwan, B., Jabeen, S.: The effect of methanolic extract of corn silk in gentamicin induced acute renal injury in rats model: methanolic extract of corn silk in gentamicin induced acute renal injury. Pak. BioMed J. 31, 308–312 (2022). https:// doi. org/10.54393/pbmj.v5i1.259
Nguemfo, E.L.; Dimo, T.; Azebaze, A.G.B.; Asongalem, E.A.; Alaoui, K.; Dongmo, A.B.; Cherrah, Y.; Kamtchouing, P. Anti-inflammatory and anti-nociceptive activities of the stem bark extracts from Allanblackia monticola STANER L.C. (Guttiferae). J. Ethnopharmacol. 2007, 114, 417–424.
Stoecklin, G.; Lu, M.; Rattenbacher, B.; Moroni, C. A constitutive decay element promotes tumor necrosis factor alpha mRNA degradation via an AU-rich element-independent pathway. Mol. Cell. Biol. 2003, 23, 3506–3515.
Habtemariam, S. Extract of Corn silk (Stigma of Zea mays) Inhibit the Tumour Necrosis Factor-α- and Bacterial Lipopolysaccharide-Induced Cell Adhesion and ICAM-1 Expression. Planta Med. 1998, 64, 314–318.
Wang, G.Q.; Xu, T.; Bu, X.M.; Liu, B.Y. Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy. Inflammation 2011, 35, 822–827.
Vijitha, T.P., Saranya, D.: Corn silk—a medicinal boon. Int. J. Chem. Tech. Res. 10(10), 129–137 (2017).
Wang, G.Q., Xu, T., Bu, X.M., Liu, B.Y.: Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleu risy. Inflammation 35(3), 822–827 (2012). https:// doi. org/ 10. 1007/s10753-011-9382-9.
Zhang, Y., et al. (2024). Highly branched polysaccharides from corn silk fermented by Lactobacillus plantarum exhibit protective effects against acute liver injury. Carbohydrate Polymers, Elsevier.
Al-Mukhtar, M. A., et al. (2020). Hepatoprotective Effect of Corn Silk Infusion in Male Wistar Rats. ResearchGate.
Akhtar, T., et al. (2021). Corn Silk Extract Reduces Hepatic Steatosis Induced by Doxorubicin in Albino Rats. The Professional Medical Journal.
Adebayo, O. S., et al. (2023). Hepatoprotective Effect of Corn Silk Extract on Liver Damage Induced by Carbonated Alcoholic Herbal Beverages in Adult Wistar Rats. Journal of Applied Sciences and Environmental Management.
Mohammadi, M., et al. (2021). Hypolipidemic and Hepatoprotective Effects of Corn Silk Extract in Nicotine-Administered Rats. Gastroenterology and Hepatology from Bed to Bench.
H.Bai, C. Hai, M.Xi,X.Liang, and R. Liu, “Protective effect of maize silks (Maydis stigma) ethanol extract on radiation induced oxidative stress in mice,” Plant Foods for Human Nutrition, vol. 65, no. 3, pp. 271–276, 2010
J. Wu,M.Ye,andZ.Wang,“Extraction,purification and anti hyperlipidemic activities of total flavonoids from corn silk,” Pakistan Journal of Zoology, vol. 49, no. 6, pp. 2173–2179, 2017.
A. S. Sahib, I. H. Mohammed, and S. J. Hamdan, “Use of aqueous extract of corn silk in the treatment of urinary tract infection,” Journal of Complementary Medicine Research, vol. 1, no. 2, pp. 93–96, 2012.
F. Xing, W. Lei, M. Tao, and Z. Qing, “Studies on antimi crobial activity of aqueous extract of maize silk,” Applied Mechanics and Materials, vol. 140, pp. 426–430, 2011.
V.Mandal,Y.Mohan, andS.Hemalatha,“Microwave assisted extraction an innovative and promising extraction tool for medicinal plant research,” Pharmacognosy Reviews, vol. 1, no. 1, pp. 7–18, 2007.
J. S. Roberts and K. A. Gerard, “Development and evaluation of microwave heating of apple mash as a pretreatment to pressing,” Journal of Food Process Engineering, vol. 27, no. 1, pp. 29–46, 2004.
I. V. Kubrakova and E. S. Toropchenova, “Microwave heating for enhancing efficiency of analytical operations (review),” Inorganic Materials, vol. 44, no. 14, pp. 1509–1519, 2008.
Zhang Y., Sui D. Y., Zhou J. S., and Zhou H. L., Microwave-assisted extraction and antihyperlipidemic effect of total flavonoids from corn silk, African Journal of Biotechnology. (2011) 10, no. 65, 14583–14586, https://doi.org/10.5897/ajb11.839
Prasad K. N., Yang B., Zhao M., Sun J., Wei X., and Jiang Y., Effects of high pressure or ultrasonic treatment on extraction yield and antioxidant activity of pericarp tissues of longan fruit, Journal of Food Biochemistry. (2010) 34, no. 4, 838–855, https://doi.org/10.1111/j.1745-4514.2010.00335.x, 2-s2.0-77955262679.
Prasad K. N., Yang B., Zhao M., Sun J., Wei X., and Jiang Y., Effects of high pressure or ultrasonic treatment on extraction yield and antioxidant activity of pericarp tissues of longan fruit, Journal of Food Biochemistry. (2010) 34, no. 4, 838–855, https://doi.org/10.1111/j.1745-4514.2010.00335.x, 2-s2.0-77955262679
Zheng L.-L., Wen G., Yuan M.-Y., and Gao F., Ultrasound-assisted extraction of total flavonoids from corn silk and their antioxidant activity, Journal of Chemistry. (2016) 2016, 5, 8768130, https://doi.org/10.1155/2016/8768130, 2-s2.0-84958580609.
Liu J., Lin S., Wang Z. et al., Supercritical fluid extraction of flavonoids from Maydis stigma and its nitrite-scavenging ability, Food and Bioproducts Processing. (2011) 89, no. 4, 333–339, https://doi.org/10.1016/j.fbp.2010.08.004, 2-s2.0-80054822270.
K. N. Prasad, B. Yang, M. Zhao, J. Sun, X. Wei, and Y. Jiang, “Effects of high pressure or ultrasonic treatment on extraction yield and antioxidant activity of pericarp tissues of longan fruit,” Journal of Food Biochemistry, vol. 34, no. 4, pp. 838–855, 2010.
A 2017 study (Biomedicine & Pharmacotherapy) reported hepatoprotection against alcohol-induced damage via SIRT1/AMPK pathway activation.
Deokar, A.M.; Deokar, G.S. and Kshirsagar, S.J.; Corn silk (Stigma Maydis) as a herbal remedie: an overview. International Journal of Institutional Pharmacy and Life sciences. 2016, 6(3): 2249-6807.
A 2014 study (Journal of Ethnopharmacology) found corn silk reduced proteinuria and inflammation in diabetic rats.
(https://pmc.ncbi.nlm.nih.gov/articles/PMC10726137/) and [hepatoprotective acidic polysaccharides](https://www.sciencedirect.com/science/article/abs/pii/S0141813023007456).
A study titled "Possible Effect of Corn Silk Extracts on Selected Liver Markers and Plasma Glucose in Rabbit" explores the hepatoprotective and hypoglycemic effects of cornsilk extracts.
Another research article, "Potential Ameliorative Effects of Corn Silk on Hepatic Damage Induced by Carbon Tetrachloride in Experimental Rats", investigates how cornsilk can improve liver and kidney function in experimental models
Salahshoor MR, Khazaei M, Jalili C, Keivan M. Crocin improves damage induced by nicotine on a number of reproductive parameters in male mice. Int J Fertil Steril 2016;10:71-78.
Saheed S, Oladipipo AE, Abdulazeez AA, Olarewaju SA, Ismaila NO, Emmanuel IA, et al. Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats. Toxicol Rep 2015;2:638-644.
Wans EM, Ahmed MM, Mousa AA, Tahoun EA, Orabi SH. Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity in rats. Environ Sci Pollut Res Int 2021;28:1762-1774.
Ernst C, Eling N, Martinez-Jimenez CP, Marioni JC, Odom DT. Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis. Nat Commun 2019;10:1251
Saheed S, Oladipipo AE, Abdulazeez AA, Olarewaju SA, Ismaila NO, Emmanuel IA, et al. Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats. Toxicol Rep 2015;2:638-644.
Wans EM, Ahmed MM, Mousa AA, Tahoun EA, Orabi SH. Ameliorative effects of corn silk extract on acetaminophen-induced renal toxicity in rats. Environ Sci Pollut Res Int 2021;28:1762-1774.
Depkes RI. 2000. General standard Parameters of Medicinal Plant Extract. Jakarta: Directorate of Traditional Medicine Supervision.
Hassanpour et al. (2014) – "Evaluation of the Diuretic Effect of Aqueous Corn Silk Extract in Healthy Volunteers." Journal of Medicinal Plants Research,
Maksimović et al. (2016) – "Effects of Corn Silk Tea on Glycemic Control in Type 2 Diabetes Mellitus: A Pilot Study." Journal of Ethnopharmacology
Habtemariam (2018) – "Antidiabetic Potential of Corn Silk: A Review." Phytotherapy Research
Wang et al. (2019) – "Comparative Study of Corn Silk Extract and Allopurinol in Hyperuricemia Management."
Lee et al. (2021) – "Corn Silk Extract on Blood Pressure in Prehypertensive Adults: A Randomized Trial."
Rahimzadeh et al. (2014) – "Vasorelaxant Effects of Corn Silk Extract on Rat Aortic Rings."
Hasanudin, K., Hashim, P., & Mustafa, S. (2012). Corn silk (Stigma maydis) in healthcare: A phytochemical and pharmacological review. Molecules, 17(8), 9697-9715.
DOI: 10.3390/molecules17089697
Guo, J., Liu, T., Han, L., & Liu, Y. (2009). The effects of corn silk on glycaemic metabolism. Nutrition & Metabolism, 6(1), 47.
DOI: 10.1186/1743-7075-6-47
Liu, J., Lin, S., Wang, Z., Wang, C., Wang, E., Zhang, Y., & Liu, J. (2011). Subchronic toxicity study of corn silk with rats. Journal of Ethnopharmacology, 137(1), 36-42.
DOI: 10.1016/j.jep.2011.03.021
World Health Organization. (2007). WHO monographs on selected medicinal plants (Vol. 3). Geneva: World Health Organization.
Duke, J.A. (2002). Handbook of medicinal herbs (2nd ed.). CRC Press
Bhat, K. S., et al. "Cornsilk: A Review of Its Medicinal Uses and Pharmacological Properties." Pharmacognosy Reviews, vol. 12, no. 23, 2018, pp. 45-53.
Rios, J. L., et al. "Flavonoids and Other Plant Phenolics as Antioxidants in Human Health." European Journal of Medicinal Chemistry, vol. 77, 2014, pp. 194-202.
Al-Amin, Z. M., et al. "Diuretic and Antioxidant Effects of Cornsilk Extracts in Rodents." Phytotherapy Research, vol. 23, no. 5, 2019, pp. 740-745.
Sharma, S., et al. "Formulation and Development of Herbal Syrups." International Journal of Pharmaceutical Sciences and Research, vol. 10, no. 1, 2022, pp. 10-18.
Barbalho, S. M., et al. "The Potential Benefits of Cornsilk Extract in Treating Urinary and Renal Health Disorders." Natural Product Research, vol. 33, no. 5, 2020, pp. 722-732.
Ibitoye, S. F., Hamid, A. A., & Mohd Ghazali, H. (2022). Antidiabetic effect of cooked corn silk methanolic extract in alloxan-induced diabetic mice. Frontiers in Pharmacology, 13, 916740. https://doi.org/10.3389/fphar.2022.916740
Kalavathi, D. F., & Rao, N. S. (2019). Therapeutic applications of corn silk: A versatile natural medicine – A comprehensive review. Indian Journal of Pharmaceutical Sciences, 81(4), 606–615. https://www.ijpsjournal.com/article/Therapeutic-Applications-of-Corn-Silk-a-Versatile-Natural-Medicine-A-Comprehensive-Review
Liu, J., Zhang, X., Yang, Y., & Wang, C. (2019). Medicinal value of corn silk: Antioxidant and anti-inflammatory effects. Scientific Grounds of Bioactive Compounds. Retrieved from https://www.scigroundbio.com/knowledge/medicinal-value-of-corn-silk
Lin, L., Zhang, J., & Dai, X. (2019). Corn silk decoction in improving lipid metabolism in patients with angina pectoris: A systematic review and meta-analysis. Complementary Therapies in Clinical Practice, 35, 281–287. https://pubmed.ncbi.nlm.nih.gov/31423665/
Abdillah, S. M., & Nugroho, A. E. (2020). Anti-cancer potential of maysin isolated from corn silk against prostate cancer cells. Indian Journal of Pharmaceutical Sciences, 82(1), 142–149. https://www.ijpsjournal.com/article/Therapeutic-Applications-of-Corn-Silk-a-Versatile-Natural-Medicine-A-Comprehensive-Review
Zhang, M., Yu, H., & Zhang, Y. (2018). Corn silk extract reduces kidney stone formation through antioxidant activity and urine output regulation in rats. Scientific Grounds of Bioactive Compounds. Retrieved from https://www.scigroundbio.com/knowledge/medicinal-value-of-corn-silk
Park, S., Kim, S., & Lee, Y. (2019). Identification of a novel ACE inhibitory peptide from corn silk and its antihypertensive effect in rats. Indian Journal of Pharmaceutical Sciences, 81(5), 965–970. https://www.ijpsjournal.com/article/Therapeutic-Applications-of-Corn-Silk-a-Versatile-Natural-Medicine-A-Comprehensive-Review
Oladeji, O. S., & Ayodele, D. T. (2018). Neuroprotective potential of ethyl acetate extract from corn silk: Inhibition of acetylcholinesterase activity. Frontiers in Neuroscience, 12, 8265. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268265/.
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