The Role of Vitamin K in Neurodegenerative Disorders: Mechanisms, Evidence, and Therapeutic Potential

Authors

  • Avik Bajaj

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Abstract

Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and Multiple Sclerosis (MS), pose significant public health challenges worldwide. Emerging evidence suggests that Vitamin K, a fat-soluble vitamin traditionally known for its role in blood coagulation, also has neuroprotective properties. This review explores the role of Vitamin K in neurodegeneration, focusing on its antioxidant, anti-inflammatory, and neuroprotective functions. It also evaluates the clinical and experimental evidence that support the potential of Vitamin K as a therapeutic agent for neurodegenerative disorders. The paper highlights the need for further research to elucidate the precise mechanisms of Vitamin K in brain health and its translational application in neurodegenerative conditions

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References

Booth, S. L. (2009). Roles for vitamin K beyond coagulation. Annual Review of Nutrition, 29, 89–110. https://doi.org/10.1146/annurev-nutr-080508-141217

Ferland, G. (2012). Vitamin K and the nervous system: An overview of its actions. Advances in Nutrition, 3(2), 204–212. https://doi.org/10.3945/an.111.001784

Presse, N., Shatenstein, B., & Ferland, G. (2013). Vitamin K status and cognitive function in healthy older adults. Neurobiology of Aging, 34(12), 2777–2783. https://doi.org/10.1016/j.neurobiolaging.2013.05.006

Li, J., Lin, J., Wang, X., & Li, X. (2020). Vitamin K2 inhibits oxidative stress-induced apoptosis in neuronal cells via activating the PI3K/Akt signaling pathway. Journal of Nutritional Biochemistry, 78, 108333. https://doi.org/10.1016/j.jnutbio.2020.108333

Ferland, G., Doucet, I., & Mainville, D. (2021). Higher vitamin K intake is associated with better cognition in elderly individuals: A prospective study. Journal of Alzheimer’s Disease, 82(1), 105–114. https://doi.org/10.3233/JAD-201058

Fu, X., Harshman, S. G., Shen, X., & Booth, S. L. (2017). Multiple vitamin K forms exist in the human brain. Current Developments in Nutrition, 1(4), e000638. https://doi.org/10.3945/cdn.117.000638

Shea, M. K., & Booth, S. L. (2008). Concepts and controversies in evaluating vitamin K status in population-based studies. Nutrition Reviews, 66(10), 558–564. https://doi.org/10.1111/j.1753-4887.2008.00113.x

Sato, Y., Honda, Y., Asoh, T., & Oizumi, K. (2001). Vitamin K2 treatment for postmenopausal osteoporosis in Parkinson’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 71(5), 589–594. https://doi.org/10.1136/jnnp.71.5.589

Wu, W., Sun, H., & Zhang, Y. (2016). Role of vitamin K2 in Parkinson’s disease: A potential therapeutic option. Medical Hypotheses, 93, 131–134. https://doi.org/10.1016/j.mehy.2016.06.024

Koenig, K. L., & Seneff, S. (2015). The roles of sulfate in neurodegenerative diseases. Environmental Health Insights, 9(Suppl 2), 31–42. https://doi.org/10.4137/EHI.S22498

Jie, K. S., Bots, M. L., Vermeer, C., Witteman, J. C., & Grobbee, D. E. (1996). Vitamin K intake and osteocalcin levels in women with and without Alzheimer’s disease: A population-based study. The American Journal of Clinical Nutrition, 63(4), 649–655. https://doi.org/10.1093/ajcn/63.4.649

Danziger, J. (2008). Vitamin K–dependent proteins, warfarin, and vascular calcification. Clinical Journal of the American Society of Nephrology, 3(5), 1504–1510. https://doi.org/10.2215

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Published

2025-07-17

How to Cite

1.
Bajaj A. The Role of Vitamin K in Neurodegenerative Disorders: Mechanisms, Evidence, and Therapeutic Potential. J Neonatal Surg [Internet]. 2025Jul.17 [cited 2025Sep.19];14(32S):5716-28. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8355