Investigating The Role of Vitamin D Supplementation In Improving Hormonal Balance In Pcos Patients: A Prospective Comparative Interventional Study
Keywords:
Polycystic Ovary Syndrome (PCOS), Vitamin D, Hormonal imbalance, Insulin resistance, Menstrual irregularity, Hyperandrogenism, FSH, LH, AMH, HOMA-IR, Cholecalciferol, Ovulatory dysfunctionAbstract
Background: Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders denoting an imbalance between hormone secretions and menstrual abnormalities with insulin resistance. Recently, it has been implicated that Vitamin D deficiency may contribute in some manner to the pathogenesis of PCOS. This study aims to assess the impact of Vitamin D supplementation on the hormonal profile, insulin sensitivity, and clinical manifestations in women with PCOS.
Methods: A prospective interventional study was carried out on 100 patients with PCOS divided into two groups: 1) One group received 60,000 IU/week of Vitamin D3 along with lifestyle modification; 2) the control group, namely, lifestyle modification alone. Clinical, hormonal, and metabolic parameters were measured at baseline and at the end of 12 weeks.
Results: The Vitamin D group showed very good improvement in menstrual disturbances, acne, hirsutism, mood swings, and weight status. Hormone levels were fully reversed, and insulin resistance was reduced significantly. The control group showed minimal changes.
Conclusion: Vitamin D supplementation is both efficacious and safe to restore the hormonal and metabolic profile in PCOS, hence can be envisaged as adjuvant therapy.
Downloads
References
Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000 Apr;141(4):1317-24.
Li M, Hu S, Sun J, Zhang Y. The role of vitamin D3 in follicle development. J Ovarian Res. 2024 Jul 17;17(1):148
Ostadmohammadi, V., Jamilian, M., Bahmani, F. et al. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res.2019;12(5).
Belenchia AM, Tosh AK, Hillman LS, et al. Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J ClinNutr 2013;97:774–781
Menichini D, Facchinetti F. Effects of vitamin D supplementation in women with polycystic ovary syndrome: a review. GynecolEndocrinol. 2020 Jan;36(1):1-5.
Lin MW, Wu MH. The role of vitamin D in polycystic ovary syndrome. Indian J Med Res. 2015 Sep;142(3):238-40.
Eman A. Sulaiman, SarraaDhiaa, Marwan M. Overview Of Vitamin D Role In Polycystic Ovarian Syndrome. Mil. Med. Sci. Lett. (Voj. Zdrav. Listy). 2022; 91(1): 37-43.
Guo S, Tal R, Jiang H, Yuan T, Liu Y. Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism. Int J Endocrinol. 2020 Dec 19;2020:7850816.
Kohlhoff, G., Kirwan, R. &Mushtaq, S. The effect of vitamin D supplementation on markers of insulin resistance in women with polycystic ovarian syndrome: a systematic review. Eur J Nutr.2024; 63: 2859–2869.
Al-Bayyari N, Al-Domi H, Zayed F, Hailat R, Eaton A. Androgens and hirsutism score of overweight women with polycystic ovary syndrome improved after vitamin D treatment: A randomized placebo controlled clinical trial. ClinNutr. 2021 Mar;40(3):870-878.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
