Correlation Between Nutritional Deficiencies (E.G., Iron, Zinc) And Lymph Node Cytology Patterns: Study In Hilly Area Of Uttarakhand
Keywords:
Iron deficiency, zinc deficiency, lymphadenopathy, FNAC, reactive hyperplasia, granulomatous lymphadenitis, Uttarakhand, nutritional statusAbstract
Background: Micronutrient deficiencies, particularly of iron and zinc, are prevalent in resource-limited regions and have known effects on immune function. This study aimed to evaluate the correlation between nutritional deficiencies and cytological patterns observed in lymph node aspirates from patients in the hilly region of Uttarakhand.
Materials and Methods: This cross-sectional study included 234 patients with peripheral lymphadenopathy who underwent fine-needle aspiration cytology (FNAC) and serum nutritional assessment. Cytological patterns were classified as reactive hyperplasia, granulomatous lymphadenitis, suppurative inflammation, or neoplastic. Serum iron and zinc levels were measured, and associations between deficiencies and cytological patterns were analyzed statistically.
Results: Iron deficiency was present in 53.8% of patients, zinc deficiency in 44.4%, and both deficiencies in 30.8%. Reactive lymphoid hyperplasia (41.9%) and granulomatous lymphadenitis (33.8%) were the most common cytological findings. A statistically significant correlation was found between iron deficiency and reactive lymphoid hyperplasia (p < 0.01), while no significant correlation was observed for zinc deficiency with specific patterns, though a higher frequency of granulomatous changes was noted in zinc-deficient individuals.
Conclusion: Iron and zinc deficiencies are common among patients with lymphadenopathy in hilly regions. Iron deficiency is significantly associated with reactive lymphoid hyperplasia, suggesting an immune-modulatory influence on cytological response. Nutritional profiling may enhance diagnostic interpretation and guide holistic patient management in endemic and underserved populations
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References
Das DK. Value and limitations of fine-needle aspiration cytology in diagnosis and classification of lymphomas: A review. DiagnCytopathol. 1999 Oct; 21(4):240-9.
Orell SR, Sterrett GF, Whitaker D. Fine Needle Aspiration Cytology. 5th ed. Churchill Livingstone; 2012.
Ghosh K, Ghosh K. Pathogenesis of anemia in malaria: a concise review. Parasitol Res. 2007 Nov; 101(6):1463-9. doi: 10.1007/s00436-007-0742-1.
Prasad AS. Zinc: an overview. Nutrition. 1995 Jan-Feb; 11(1 Suppl):93-9.
Pathak P, Kapil U, Kapoor SK, Saxena R, Kumar A, Gupta N, et al. Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana. Indian J Pediatr. 2004 Nov; 71(11):1007-14. doi: 10.1007/BF02828117.
Sharma SK, Mohan A, Kohli M. Extrapulmonary tuberculosis. Expert Rev Respir Med. 2021 Jul; 15(7):931-948. doi: 10.1080/17476348.2021.1927718.
Patil RK, Joshi Z, Medar PS, Haravi RM. Cytomorphological study of lymph node in tertiary care hospital. Int J Pharm Clin Res. 2024; 16(3):1–7.
Wilkinson AR, Mahore SD, Maimoon SA. FNAC in the diagnosis of lymph node malignancies: A simple and sensitive tool. Indian J Med PaediatrOncol. 2012 Jan; 33(1):21-4. doi: 10.4103/0971-5851.96964.
Mu Q, Chen L, Gao X, Shen S, Sheng W, Min J, Wang F. The role of iron homeostasis in remodeling immune function and regulating inflammatory disease. Sci Bull (Beijing). 2021 Sep 15; 66(17):1806-1816. doi: 10.1016/j.scib.2021.02.010.
Peng YY, Uprichard J. Ferritin and iron studies in anaemia and chronic disease. Ann Clin Biochem. 2017 Jan; 54(1):43-48. doi: 10.1177/0004563216675185.
Haase H, Rink L. The immune system and the impact of zinc during aging. Immun Ageing. 2009 Jun 12; 6:9. doi: 10.1186/1742-4933-6-9.
Wessels I, Fischer HJ, Rink L. Dietary and Physiological Effects of Zinc on the Immune System. Annu Rev Nutr. 2021 Oct 11; 41:133-175. doi: 10.1146/annurev-nutr-122019-120635.
Gammoh NZ, Rink L. Zinc in Infection and Inflammation. Nutrients. 2017 Jun 17;9(6):624. doi: 10.3390/nu9060624.
Saha J, Maity M, Roy SK, Ghosal S. Nutritional and health status of tribal people: a review. J Adv Zool. 2023 Dec; 44(Suppl 6):1950–5
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