A Systemic Disquisition on Pancreatic Neoplasia in all age groups: An Exhaustive Appraisal of Diagnostic Stratification, Histopathological Paradigms, and the Multimodal Oncotherapeutic Spectrum based on 13 high end studies

Authors

  • Suhena Sarkar
  • Birupaksha Biswas
  • Kaustuv Banerjee
  • Jefri S. Bale
  • Paul G. Tamelan

Keywords:

Pancreatic Neoplasms, PDAC, Molecular Diagnostics, Histopathology, FOLFIRINOX, PARP Inhibitors, EUS-FNA, Targeted Therapy, Precision Oncology, Neoadjuvant Chemotherapy, Tumor Microenvironment, Pancreatic Surgery, 68Ga-DOTATATE PET/CT, Liquid Biopsy, KRAS

Abstract

Pancreatic neoplasms represent one of the most insidious and biologically aggressive oncological entities, often eluding early detection and exhibiting dismal prognostication despite evolving molecular and therapeutic frontiers. This systematic review synthesizes evidence from 13 pivotal, high-impact studies to elucidate the diagnostic modalities, histopathological intricacies, and advanced oncologic treatment modalities—including chemotherapeutic regimens, molecular-targeted therapies, and surgical innovations—in pancreatic malignancies. Through comprehensive analysis, this review seeks to integrate clinical, histomolecular, and therapeutic determinants into a cohesive algorithm for contemporary management

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Published

2025-07-22

How to Cite

1.
Sarkar S, Biswas B, Banerjee K, Bale JS, Tamelan PG. A Systemic Disquisition on Pancreatic Neoplasia in all age groups: An Exhaustive Appraisal of Diagnostic Stratification, Histopathological Paradigms, and the Multimodal Oncotherapeutic Spectrum based on 13 high end studies. J Neonatal Surg [Internet]. 2025Jul.22 [cited 2025Oct.14];14(32S):6119-30. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8459

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

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