Formulation and Characterization of Methotrexate Loaded Nanotubes for Rheumatoid Arthritis
Keywords:
Functionalization, Nanotubes, Amidated, Internalization, BiocompatibilityAbstract
The goal of this work was to developed and characterize multiwall carbon nanotubes conjugated with dexamethasone. Fourier transform infrared was used to confirm that the dexamethasone was conjugated to amidated multi-walled carbon nanotubes (MWCNTs). Both pristine and functionalized MWCNTs were loaded with methotrexate, which was then thoroughly described in vitro. Dexamethasone conjugated MWCNTs were shown to have a high drug entrapment efficiency. It was discovered that the in vitro drug release from the formulation of pristine MWCNTs and dexamethasone coupled MWCNTs was 57.81 ±1.2 and 65.23 ± 1.4% in 24 hours, respectively, in PBS (pH 7.4)
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