A Case Report On Mild Symptomology -Antiphospholipid Antibody (Apla)

Authors

  • Dharshini A.D
  • Rakkesh Praveen. S
  • M. Dheenadhayalan
  • K. Karthickeyan
  • P. Shanmugasundaram
  • M. K. Sundar Sri

Keywords:

APLA (Antiphospholipid Antibody), Systemic Lupus Erythematosus (SLE), transverse sigmoid colon

Abstract

Antiphospholipid Antibody (APLA) Syndrome is an autoimmune condition marked by a hypercoagulable state, which predisposes individuals to thrombosis in both arterial and venous vessels throughout the body. This disorder is commonly associated with complications such as thromboembolic events and pregnancy issues. According to population-based studies, the estimated incidence ranges from 1 to 2 cases per 100,000 individuals, while the prevalence is reported to be between 40 and 50 cases per 100,000. APS can present as a primary or as a secondary condition in association with Systemic Lupus Erythematosus (SLE) or other autoimmune diseases. APLA is a diverse and can vary from clinical presentation. Therefore here, a case of 21year old female patient presented with complaints of numbness in left UL for 6 months, neck pain in (R) side. At the age of 5, the patients had medical history of jaundice and the patient had persistent headache and was worsen and Brain MRI showed (L) Thalamic infarct hypoplasia transverse and sigmoid colon. The patient was treated with initial stage of first line medication such as blood transfusion, multivitamin and analgesic medication. Here, I have presented with antiphospholipid antibody syndrome patient with observed minor complication such as splenomegaly, constipation, calcified granuloma which was detected in CT whole abdomen. In MRI with lumbar spine screening showed mild disc bulging with small profusion in the lumbar region.

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References

Knight JS, Branch DW, Ortel TL. Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management. Bmj. 2023 Feb 27;380. Primary Anti-Phospholipid Antibody Syndrome (APS): Current Concepts

Guerrero-Rodriguez E, Padilla-Medina JR, Reyes-Fernández PM, Peña-Martínez VM, Saavedra-Badillo LA, Acosta-Olivo CA. Spinal epidural hematoma in antiphospholipid syndrome: case report and review of the literature. Spinal Cord Series and Cases. 2022 Jan 18;8(1):11.

Barreno-Rocha SG, Guzmán-Silahua S, Rodríguez-Dávila SD, Gavilanez-Chávez GE, Cardona-Muñoz EG, Riebeling-Navarro C, Rubio-Jurado B, Nava-Zavala AH. Antiphospholipid antibodies and lipids in hematological malignancies. International Journal of Molecular Sciences. 2022 Jan;23(8):4151.

Cikrikcioglu MA, Hursitoglu M, Erkal H, Inan B, Ozturk T, Cakirca M, Canpolat F, Erkal S, Bahtiyar I, Cordan I, Tukek T. Splenomegaly in primary antiphospholipid syndrome without accompanying portal hypertension or comorbidity. Pathophysiology of Haemostasis and Thrombosis. 2011 May 10;37(2-4):104-9.

Mazzoccoli C, Comitangelo D, D’Introno A, Mastropierro V, Sabbà C, Perrone A. Antiphospholipid syndrome: a case report with an unusual wide spectrum of clinical manifestations. Autoimmunity Highlights. 2019 Dec; 10:1-5.

Sur LM, Floca E, Sur DG, Colceriu MC, Samasca G, Sur G. Antinuclear antibodies: marker of diagnosis and evolution in autoimmune diseases. Laboratory medicine. 2018 Jul 5;49(3):e62-73.

Abdel-Wahab N, Tayar JH, Fa'ak F, Sharma G, Lopez-Olivo MA, Yousif A, Shagroni T, Al-Hawamdeh S, Rojas-Hernandez CM, Suarez-Almazor ME. Systematic review of observational studies reporting antiphospholipid antibodies in patients with solid tumors. Blood Advances. 2020 Apr 28;4(8):1746-55.

Scandolara TB, Panis C. Neutrophil traps, anti-myeloperoxidase antibodies and cancer: Are they linked?. Immunology Letters. 2020 May 1;221:33-8.

Sun Q, Wang L, Zhu HY, Miao Y, Wu W, Liang JH, Cao L, Xia Y, Wu JZ, Wang Y, Wang R. Presence of serum antinuclear antibodies correlating unfavorable overall survival in patients with chronic lymphocytic leukemia. Chinese Medical Journal. 2019 Mar 5;132(05):525-33.

Lang J, Ma K, Guo J, Zhang J, Wang Q, Sun H. Clinical significance of elevated antinuclear antibodies in patients with diffuse large B-cell lymphoma: a single center study. Journal of cancer research and therapeutics. 2018 Jan 1;14(1):213-9.

Dabit JY, Valenzuela-Almada MO, Vallejo-Ramos S, Duarte-García A. Epidemiology of antiphospholipid syndrome in the general population. Current rheumatology reports. 2021 Dec;23(12):85.

Andreoli L, Chighizola CB, Banzato A, Pons‐Estel GJ, de Jesus GR, Erkan D, APS ACTION. Estimated frequency of antiphospholipid antibodies in patients with pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature. Arthritis care & research. 2013 Nov;65(11):1869-73.

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Published

2025-07-26

How to Cite

1.
A.D D, Praveen. S R, Dheenadhayalan M, Karthickeyan K, Shanmugasundaram P, Sundar Sri MK. A Case Report On Mild Symptomology -Antiphospholipid Antibody (Apla). J Neonatal Surg [Internet]. 2025Jul.26 [cited 2025Sep.19];14(32S):6341-6. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8550

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