Persistant Hyperinsulinemic Hypoglycaemia Of Infancy And Neonates : Surgical Management And Intermediate Term Outcomes

Authors

  • Nischita Nischita
  • M Bellad
  • Bhagyajyothi
  • B. Khanagavi
  • Dr Santosh
  • B. Kurbet
  • M V. Patil

Abstract

Persistent hyperinsulinemic hypoglycaemia of infancy, also called nesidioblastosis, or congenital hyperinsulinism, is a disease characterized by hyperinsulinemia even with hypoglycaemia, which may result in brain dysfunction as the brain thrives on glucose exclusively. The other causes of this hypoglycaemia are ruled out before aggressive medical treatment. Finally, surgical treatment is advised, where the use of early surgery, which is major, involving near complete removal of the pancreas, is undertaken. Here, we try to address the management with these four cases.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Vane DW, Grosfeld JL. West KW, et al. Pancreatic disorders in infancy and childhood: Experience with 92 cases. J Pediatr Surg 24:771-776,1989

Jay L Grosfeld, Arnold Coran, James O Neil, et al. Paediatric surgery, 2012. 7th edition : vol 2

Thomas CG Jr, Cuenca RE, Azizkhan RG, et al : Changing concepts of islet cell dysplasia in neonatal and infantile hyperinsulinism. World J Surg 1988; 12:598.

Arnoux JB, de Lonlay P, Ribeiro MJ et.al. Congenital hyperinsulinism. Early Hum Dev. 2010 May;86(5):287-94. Epub 2010 Jun 13.

Pierro A, Nah SA. Surgical management of congenital hyperinsulinism of infancy. Semin Pediatr Surg. 2011 Feb;20(1):50-3.

Spitz L, Buick DG, Grant OB.et al : Surgical treatment of nesidioblastosis. Pediatr Surg Int 1986;1.

Downloads

Published

2025-08-13

How to Cite

1.
Nischita N, Bellad M, Bhagyajyothi B, Khanagavi B, Santosh D, Kurbet B, Patil MV. Persistant Hyperinsulinemic Hypoglycaemia Of Infancy And Neonates : Surgical Management And Intermediate Term Outcomes. J Neonatal Surg [Internet]. 2025Aug.13 [cited 2025Oct.13];14(32S):7486-8. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8639

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

License

Copyright (c) 2025 Nischita Nischita, M Bellad, Bhagyajyothi, B. Khanagavi, Dr Santosh, B. Kurbet, M V. Patil

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  • Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.