Pulmonary Metastasis In Recurrent Myxoid Liposarcoma Despite Histological Grade -A CASE REPORT

Authors

  • Deepak. H
  • Samuel Mark Franklin
  • V Balaji
  • Ganesh. R
  • K. Karthickeyan

DOI:

https://doi.org/10.63682/jns.v14i31S.8642

Keywords:

Myxoid Liposarcoma, Soft Tissue Sarcoma, Pulmonary Metastasis, FNCLCC Grade 1, Chemotherapy, Recurrence

Abstract

Background: Myxoid liposarcoma is an uncommon malignancy of adipocyte origin in soft tissue. Despite being characteristically low-grade, it has an uncharacteristic tendency for recurrence and distant metastasis, most frequently to the lung. A case of recurrent myxoid liposarcoma with swelling of the right leg and metastasis to the lung in a 60-year-old male is described here.

Case Report: A 60-year-old male patient presented with a history of recurrent calf swelling of the right leg and multiple previous excisions (2005, 2010, 2014) presented with a new calf swelling. Imaging and biopsy revealed recurrent myxoid liposarcoma. PET-CT revealed local invasion and pulmonary metastasis. Chemotherapy with gemcitabine and docetaxel was initiated. Lifestyle counseling and a follow-up visit were advised.

Conclusion: This case highlights the importance of Myxoid liposarcoma, though a low-grade sarcoma, is characterized by extensive local invasion and distant metastasis. Early treatment and appropriate systemic management are essential to manage recurrence and metastasis.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Antonescu CR, Elahi A, Zhang L, et al. Molecular characterization of myxoid liposarcoma: association between FUS-DDIT3 fusion transcript and tumor grade. Mod Pathol. 2000;13(11):1211–1218. https://doi.org/10.1038/ modpathol.3880215

Chung PW, et al. Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma. Cancer. 2009;115(14):3254–3261. doi:10.1002/cncr.24337

Nishida Y, Tsukushi S, Urakawa H, et al. Late metastasis of myxoid liposarcoma: a report of two cases and a review of the literature. World J Surg Oncol. 2012;10:218. https://doi.org/10.1186/1477-7819-10-218

Pitson G, Robinson P, Wilke D, et al. Radiation response: an additional unique feature of myxoid liposarcoma. Int J Radiat Oncol Biol Phys. 2004;60(2):522–526.https://doi.org/10.1016/j.ijrobp.2004.04.005

Italiano A, Toulmonde M, Stoeckle E, et al. Clinical outcome of patients with metastatic soft-tissue sarcoma treated with gemcitabine and docetaxel: a retrospective multicenter study. Cancer. 2012;118(19):4569–4576.https://doi.org/10.1002/cncr.27458

Gronchi A, Lo Vullo S, Colombo C, et al. Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival. Ann Surg. 2010;251(3):506–511.https://doi.org/ 10.1097/SLA.0b013e3181cf87fa

Fiore M, Grosso F, Lo Vullo S, et al. Myxoid/round cell and pleomorphic liposarcomas: prognostic factors and survival in a series of patients treated at a single institution. Cancer. 2007;109(12):2522–2531.https://doi.org/ 10.1002/cncr.22748

Downloads

Published

2025-07-30

How to Cite

1.
H D, Mark Franklin S, Balaji V, R G, Karthickeyan K. Pulmonary Metastasis In Recurrent Myxoid Liposarcoma Despite Histological Grade -A CASE REPORT. J Neonatal Surg [Internet]. 2025Jul.30 [cited 2025Sep.19];14(31S):1008-11. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8642

Most read articles by the same author(s)

1 2 > >>