Comparative and clinical evaluation of 1% curcumin chip versus 1% tetracycline chip as a local drug delivery agent in treating chronic localised periodontitis - a randomized control trial.
Keywords:
Tetracycline chip, curcumin chip, scaling and root planing, chronic periodontitisAbstract
Aim: To assess the efficacy of 1% Tetracycline chip and 1% Curcumin chip in management of CP patients when used as an adjunct to SRP.
Materials and methods: 30 patients with CP contributing a total of 90 sites [ n = 30 each] were randomly assigned to receive one of the three treatment protocols; i.e., Group 1: SRP + 1% Tetracycline chip, Group 2: SRP + 1% Curcumin chip. Group 3: SRP alone. The following clinical parameters such as Probing Pocket Depth, Plaque Index, Gingival Index, Bleeding index were assessed at Baseline, 1 month, 3 months. Microbiological assessment was done at Baseline & 3 months.
Conclusion: The results of this study suggested that local application of 1% Tetracycline chip was as effective and as beneficial as 1% Curcumin chip, in the treatment of CP patients and hence can be recommended as a treatment option for CP patients.
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Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Periodontology. 2018 Jun;89(S1):S173–82.
Mombelli A. Microbial colonization of the periodontal pocket and its significance for periodontal therapy. Periodontology 2000. 2017 Nov 30;76(1):85–96.
Keestra JAJ, Grosjean I, Coucke W, Quirynen M, Teughels W. Non-surgical periodontal therapy with systemic antibiotics in patients with untreated aggressive periodontitis: a systematic review and meta-analysis. Journal of Periodontal Research. 2014 Dec 18;50(6):689–706.
Goodson J. Antimicrobial strategies for treatment of periodontal diseases. Periodontol 2000 1994;5:142–168.
Dodwad V, Vaish S, Mahajan A, Chhokra M. Local drug delivery in periodontics: A strategic intervention. Int J Pharm Pharm Sci. 2012;4:30-4.
Divya P, Nayar B, Nandakumar K. Clinical efficacy of sustained release chlorhexidine in collagen membrane in the non-surgical management of chronic localised periodontitis. IOSR J Dent Med Sci. 2018;17:22-9.
Singh A, Sridhar R, Shrihatti R, Mandloy A. Evaluation of Turmeric Chip Compared with Chlorhexidine Chip as a Local Drug Delivery Agent in the Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Clinical Trial. The Journal of Alternative and Complementary Medicine. 2018 Jan;24(1):76–84.
Dang AB, Chaubey KK, Thakur RK, Mohan R, Chowdhary Z, Tripathi R. Comparative evaluation of efficacy of three treatment modalities - tetracycline fibers, scaling and root planing, and combination therapy: A clinical study. J Indian Soc Periodontol. 2016;20(6):608
Kukreja B, Dodwad V. Herbal mouthwashes - A gift of nature. Int J Pharma Bio Sci. 2012;3:P46-52.
Naidu S, Suresh A. Effects of turmeric (Curcuma longa) in dentistry. Int J Dev Res. 2018;8(7):21828-31.
Gupta SC, Patchva S, Koh W, Aggarwal BB. Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012;39(3):283-99. doi:10.1111/j.1440-1681.2011.05648.x
Bankur PK, Fatima G, Samee A, Rahman F, Quadri SM, Ansari MW. Effects of Curcumin and Tetracycline Fibers as Local Drug Delivery Agents in Treating Chronic Periodontitis: A Microbiological Study. World J Dent. 2024;15(12):1066-70.
Kudva P, Tabasum ST, Gupta S. Comparative evaluation of the efficacy of turmeric and curcumin as a local drug delivery system: a clinicomicrobiological study. Gen Dent. 2012 Sep;60(5):e283-7.
Gottumukkala SN, Sudarshan S, Mantena SR. Comparative evaluation of the efficacy of two controlled release devices: Chlorhexidine chips and indigenous curcumin-based collagen as local drug delivery systems. Contemp Clin Dent. 2014 Apr;5(2):175-81.
Anitha V, Rajesh P, Shanmugam M, Meera Priya B, Prabhu S, Shivakumar V. Comparative evaluation of natural curcumin and synthetic chlorhexidine in the management of chronic periodontitis as a local drug delivery: A clinical and microbiological study. Indian J Dent Res. 2015 Jan-Feb;26(1):53-6. doi:10.4103/0970-9290.156806
Shivanand P. Evaluation of Curcumin 10mg (Curenext*®) as Local Drug Delivery in the Treatment of Chronic Periodontitis-A Clinical, Microbiological and Biochemical Approach (Master's thesis, Rajiv Gandhi University of Health Sciences (India)).
Hugar SS, Patil S, Metgud R, Nanjwade B, Hugar SM. Influence of application of chlorhexidine gel and curcumin gel as an adjunct to scaling and root planing: An interventional study. J Nat Sci Biol Med. 2016;7(2):149-54. doi:10.4103/0976-9668.184701
Ravishankar PL, Kumar YP, Anila EN, Chakraborty P, Malakar M, Mahalakshmi R. Effect of local application of curcumin and ornidazole gel in chronic periodontitis patients. Int J Pharm Investig. 2017 Oct;7(4):188.
Rangrej U, Dave D, Rai J, Vaghani K. Evidence-based review on herbal local drug delivery. IOSR J Dent Med Sci. 2017;16(8):77-85. doi:10.9790/0853-1608017785.
Raghava KV, Sistla KP, Narayan SJ, et al. Efficacy of curcumin as an adjunct to scaling and root planing in chronic periodontitis patients: a randomized controlled clinical trial. J Contemp Dent Pract. 2019 Jul;20(7):842-6. PMID: 31597806.
Harshan P, Fathima L, Manipal S. Systematic review on effectiveness of curcumin in treatment of periodontitis. J Pharm Sci Res. 2019 Sep 1;11(9):3174-80.
Siddharth M, Singh P, Gupta R, Sinha A, Shree S, Sharma K. A comparative evaluation of subgingivally delivered 2% curcumin and 0.2% chlorhexidine gel adjunctive to scaling and root planing in chronic periodontitis. J Contemp Dent Pract. 2020 May 1;21(5):494-9.
Li Y, Jiao J, Qi Y, et al. Curcumin: a review of experimental studies and mechanisms related to periodontitis treatment. J Periodontal Res. 2021;56(5):837-47. doi:10.1111/jre.12914
Terby S, Shereef M, Ramanarayanan V, Balakrishnan B. The effect of curcumin as an adjunct in the treatment of chronic periodontitis: a systematic review and meta-analysis. Saudi Dent J. 2021 Nov 1;33(7):375-85.
Pérez-Pacheco CG, Fernandes NA, Primo FL, Tedesco AC, Bellile E, Retamal-Valdes B, et al. Local application of curcumin-loaded nanoparticles as an adjunct to scaling and root planing in periodontitis: randomized, placebo-controlled, double-blind split-mouth clinical trial. Clin Oral Investig. 2021 May;25:3217-27.
Vijayapremakumar VK, Mehta A, Shivanand P, Prakash S. Nature’s anti-inflammatory agent and its use as a local drug delivery agent for treatment of chronic periodontitis: a clinical, microbiological and biochemical study. J Ayurvedic Herb Med. 2021;7(1):30-5.
Saini K, Chopra P, Bhardwaj A, Yadav M, Saini S. Comparative clinical evaluation of two local drug delivery agents (neem chip and turmeric chip) in chronic periodontitis: an experimental study. World J Dent. 2021 Apr 1;12(2):138-43.
Raj A. Comparative clinical evaluation of tetracycline fibers with curcumin incorporated collagen fibers—a randomised clinical study [dissertation]. Lucknow (IN): Bbdcods; 2021.
Kamath KK, Shabaraya AR, Kumar M. Review on local drug delivery systems for periodontitis. 2021.
Rahalkar A, Kumathalli K, Kumar R. Determination of efficacy of curcumin and Tulsi extracts as local drugs in periodontal pocket reduction: a clinical and microbiological study. J Indian Soc Periodontol. 2021 May 1;25(3):197-202.
Sufaru IG, Martu MA, Luchian I, Teslaru S, Stoleriu S, Stratul SI, et al. Advances in locally delivered antimicrobials for periodontitis treatment. In: Periodontology - New Insights. London: IntechOpen; 2022 Sep 21.
Solomon SM, Stafie CS, Sufaru IG, Teslaru S, Ghiciuc CM, Petrariu FD, et al. Curcumin as a natural approach of periodontal adjunctive treatment and its immunological implications: a narrative review. Pharmaceutics. 2022 May 3;14(5):982.
Mukherji A, Bose S. Turmeric as a local drug delivery in periodontitis: a review of literature. CHRISMED J Health Res. 2022 Jul–Sep;9(3):147-53. doi:10.4103/cjhr.cjhr_121_21
Amato M, Santonocito S, Polizzi A, Tartaglia GM, Ronsivalle V, Viglianisi G, et al. Local delivery and controlled release drugs systems: a new approach for the clinical treatment of periodontitis therapy. Pharmaceutics. 2023 Apr 21;15(4):1312.
Viglianisi G, Santonocito S, Lupi SM, Amato M, Spagnuolo G, Pesce P, Isola G. Impact of local drug delivery and natural agents as new target strategies against periodontitis: new challenges for personalized therapeutic approach. Ther Adv Chronic Dis. 2023 Sep;14:20406223231191043.
Hatila S, Lahiri B, Sunnanguli G, Jayachandran M, Gopakumar R, Devi KB, Kamil MA. Comparative assessment of the effect of three various local drug delivery medicaments in the management of chronic periodontitis. J Contemp Dent Pract. 2023 Mar 1;24(3):162-7.
Wendorff-Tobolla LM, Wolgin M, Wagner G, Klerings I, Dvornyk A, Kielbassa AM. A systematic review and meta-analysis on the efficacy of locally delivered adjunctive curcumin (Curcuma longa L.) in the treatment of periodontitis. Biomedicines. 2023 Feb 7;11(2):481.
Chaturvedi A, Sheokand V, Bhardwaj A, Wadhwa V. Comparative evaluation of local drug delivery using chitosan chip and 1% curcumin gel on Porphyromonas gingivalis: a clinico-microbiological study. World. 2024 Aug;15(8):703.
AM, Waghmare P, Dodwad VM, Kaur A. Herbal local drug delivery: a narrative review. Indian J Dent Sci. 2024 Jul 1;16(3):147-52.
Chaubal TV, Ywen BS, Ying Ying T, Bapat R. Clinical and microbiologic effect of local application of curcumin as an adjunct to scaling and root planing in periodontitis: systematic review. Ir J Med Sci. 2024 Aug;193(4):1985-94.
Prasanna JS, SaiPriya J. Evaluation of the efficacy of herbal (neem) and chemical (chlorhexidine) chips as local drug delivery agents in the treatment of chronic periodontitis: a clinical and microbiological study. J Oral Res Rev. 2025 Jan 1;17(1):35-46.
Prasanna HR, Chetan, Krishna K, Harieesha K, Sabah F, Surya Sreevatsa CM. Comparative and clinical evaluation of 1% curcumin chip versus 1% tetracycline chip as a local drug delivery agent in the form of biodegradable chip in treating chronic localized periodontitis: an immunological study. Afr J Biomed Res. 2025;28(1S):1382-93.
Malekzadeh M, Kia SJ, Mashaei L, Moosavi S. Oral nano-curcumin on gingival inflammation in patients with gingivitis and mild periodontitis. Clin Exp Dent Res. 2021;7(1):78-84. doi:10.1002/cre2.330
Kamath DG, Haidrus R. Local drug delivery in periodontal therapy: a contemporary review. Adv Pharmacoepidemiol Drug Saf. 2021;10:245.
Nadig P, Shah M. Tetracycline as local drug delivery in treatment of chronic periodontitis: a systematic review and meta-analysis. J Indian Soc Periodontol. 2016;20:576-83.
Singh M, Shreehari AK, Garg PK, Singh S. Clinical efficacy of chlorhexidine chips and tetracycline fibers as an adjunct to non-surgical periodontal therapy. Eur J Gen Dent. 2014;3:134-9.
Friesen LR, Williams KB, Krause LS, Killoy WJ. Controlled local delivery of tetracycline with polymer strips in the treatment of periodontitis. J Periodontol. 2002;73(1):13-9. doi:10.1902/jop.2002.73.1.13
Muglikar S, Patil KC, Shivswami S, Hegde R. Efficacy of curcumin in the treatment of chronic gingivitis: a pilot study. Oral Health Prev Dent. 2013;11(1):81–6.
Heijl L, Dahlen G, Sundin Y, Wenander A, Goodson JM. A 4-quadrant comparative study of periodontal treatment using tetracycline-containing drug delivery fibers and scaling. J Clin Periodontol. 1991;18(2):111–6. doi:10.1111/j.1600-051x.1991.tb01699.x
Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: a clinical and microbiological study. J Indian Soc Periodontol. 2011;15(1):35–8. doi:10.4103/0972-124X.82266
Suhag A, Dixit J, Dhan P. Role of curcumin as a subgingival irrigant: a pilot study. Perio. 2007;4(2):115–21.
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