Evaluation Of Factors That Affect Acceptance Of Split Thickness Skin Graft (STSG)
Keywords:
STSG, skin graft acceptance, graft rejection, comorbidities, postoperative infection, surgical outcomesAbstract
Background: Split thickness skin grafts (STSGs) remain a cornerstone in reconstructive and burn surgery due to their versatility and effectiveness. Despite their widespread application, variability in graft acceptance persists due to several patient and procedural factors.
Methods: A prospective observational study was conducted at Krishna Institute of Medical Sciences, Karad, from May 2023 to December 2024. Thirty-five patients undergoing STSG were evaluated based on pre- and postoperative variables including age, comorbidities, addictions, and fixation techniques. Statistical analysis was performed using SPSS v20.
Results: Patients under 35 years demonstrated the highest graft acceptance rates (p=0.033). Comorbidities, particularly diabetes mellitus, significantly reduced graft survival (p=0.027). Gender and addictions did not show statistically significant correlation with graft acceptance. Postoperative infection and fixation technique played substantial roles in graft outcomes.
Conclusion: Age and systemic comorbidities are critical predictors of STSG acceptance. Proper patient selection, preoperative optimization, and infection control can enhance graft survival and patient outcomes.
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References
Johnson TM, Ratner D, Nelson BR. Skin and skin disorders. In: Goldman L, Schafer AI, editors. Goldman-Cecil Medicine. 24th ed. Philadelphia: Elsevier Saunders; 2011.
Atiyeh BS, Hayek SN. Management of acute and chronic open wounds: the importance of moist environment in optimal wound healing. Curr Pharm Biotechnol. 2005;6(4):349–66.
Brissett AE, Sherris DA. Skin grafts, flaps, and local tissue rearrangement. Otolaryngol Clin North Am. 2001;34(3):489–500.
Cigna E, Buccheri EM, Monarca C, et al. Split-thickness skin grafts: Histological studies and clinical evaluation. J Cutan Aesthet Surg. 2009;2(2):68–72.
Janzekovic Z. A new concept in the early excision and immediate grafting of burns. J Trauma. 1970;10(12):1103–8.
Voineskos SH, Ayeni OA, McKnight L, et al. Systematic review of skin graft donor-site dressings. Plast Reconstr Surg. 2009;124(1):298–306.
Winter GD. Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature. 1962;193:293–4.
Nischal KC, Khopkar U. Skin grafts. In: Valia RG, Valia AR, editors. IADVL Textbook of Dermatology. 3rd ed. Mumbai: Bhalani Publishing House; 2008.
Sinha R, Maitra S, Ray S, et al. Evaluation of wound bed preparation and its impact on acceptance of skin graft. Int Surg J. 2018;5(1):104–9.
Rudraiah HGM, Honnungar RS, Shivamurthy MC. Factors affecting acceptance of split thickness skin graft in surgical wounds. MedPulse Int Med J. 2017;4(10):678–81.
Subrahmanyam M. A prospective randomized clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns. 1998;24(2):157–61.
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