Development and Evaluation of Gallic Acid- Loaded Solid Lipid Nano-particles
Keywords:
Solid Lipid Nano-particles, Gallic acid, preformulation, in-vitro drug release.Abstract
The current study was based on the Development and Evaluation of Gallic Acid- Loaded Solid Lipid Nano-particles. Gallic acid was purchased from the Oxford Lab Fine Chem LLP, India. Stearic acid, Span 20, Tweens 80 (Sigma Aldrich, India), distilled water, ethanol were procured from the local chemical shop in Haridwar, UK. In Preformulation studies, various parameters i.e., organoleptic properties, melting point, solubility, Drug excipients compatibility studies and Preparation of Standard Calibration Curve. Preparation of gallic acid- based solid lipid nanoparticles was done using spray-drying method. It was characterized for various parameters i.e., Physical appearance, Entrapment efficiency, Drug content determination, pH determination, Determination of particles size & PDI, SEM analysis, In vitro drug release and Stability studies. Gallic acid was found partial soluble in distilled water and soluble in Tween 80 and Span 20, ethanol and DMSO. Both stearic acid and cholesterol dissolved it sparingly. After 6 hours, F3 and F4 showed % drug release as 96.4±0.2, 93.2±0.5 %, respectively. Maximum release was found in F3. In conclusion, among the several forms of solid lipid nanoparticles of gallic acid, F3 demonstrated the most significant formulation i.e., in-vitro drug release, droplet size, and drug content. It also showed improved stability, with no significant change in pH, % drug release and physical appearances after being stored for 30 days. Gallic acid is promising natural moiety with a wide range of potential health benefits. Gallic acid solid lipid nanoparticles can be utilized as anti-fungal or anti-bacterial agent with sustained release
Downloads
Metrics
References
Tyagi P, J.A. Subramony. Guidance for Industry: Considering Whether an FDA-Regulated Product Involves the Application of Nanotechnology, Food and Drug Administration (Accessed 02 Fig. 4. Schematic showing flexibility for developing immunotherapy combinations based on patient parameters such as tumor phenotype and tumor biomarker information. Journal of Controlled Release, 2018; 272:159-168.
Liu L, Q. Ye, M. Lu, Y.C. Lo, Y.H. Hsu, M.C. Wei, Y.H. Chen, S.C. Lo, S.J. Wang, D.J. Bain, C. Ho, A new approach to reduce toxicities and to improve bioavail- abilities of platinum-containing anti-cancer nanodrugs, Sci. Rep. 5 (2015) 10881.
Merisko-Liversidge E, G.G. Liversidge. Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology, Adv. Drug Deliv. Rev. 63 (2011) 427-440.
Maeda H, H. Nakamura, J. Fang, The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo, Adv. Drug Deliv. Rev. 65 (2013) 71–79.
Mukherjee S, S. Ray and R. S. Thakur, Ind. J. Pharm. Sci., 349-358 (2009).
Fernandes F, Salgado H. Gallic acid: review of the methods of determination and quantification. Crit Rev Anal Chem. 2016;46:257–265.
Choubey S, Varughese L, Kumar V, Beniwal V. Medicinal importance of gallic acid and its ester derivatives: a patent review. Pharm Pat Anal. 2015;4:305–315.
Samiullah, Jan SU, Gul R, Jalaludin S, Asmathullah, “formulation and evaluation of transdermal patches of pseudoephedrine HCL”, International Journal of Applied Pharmaceutics, 2020,12(3), 121-127.
Chauhan SB, Saini S, “formulation and evaluation of transdermal patches of metoprolol tartrate using permeation enhancers of natural and synthetic origin”, Int J App Pharm, 2019,11(5), 293-298.
Kulkarni S. Formulation and Evaluation of Transdermal Patch for Atomoxetine hydrochloride. JDDT, 2019;9(2-A):32-5.
Jirapornchai Suksaeree, Chomnapas Chuchote. Accelerated Stability Testing of a Polyherbal Transdermal Patches Using Polyvinyl Alcohol and Hydroxypropyl Methylcelluloseas a Controlling Polymer Layer. Journal of Polymers and the Environment (2018) 26:4056–4062.
Kavitha K and More Mangesh Rajendra, Design and Evaluation of Transdermal Films of Lornoxicam, IJPBS, 2011, 2(2), 54-62.
Shalu Rani, Kamal Saroha, Navneet Syan, Pooja Mathur, Transdermal Patches A Successful Tool In Transdermal Drug Delivery System: An overview, Der Pharmacia Sinica, 2011, 2 (5), 17-29.
D NV, Shrestha N, Sharma J. Transdermal drug delivery system: An overview. Int J Res Pharm Sci. 2012;3(2):234–41.
Kyriakides T.R., Raj A., Tseng T.H., Xiao H., Nguyen R., Mohammed F.S., Halder S., Xu M., Wu M.J., Bao S., et al. Biocompatibility of nanomaterials and their immunological properties. Biomed. Mater. 2021;16:042005.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
