Development of Tamarindus indica seed Derived polysaccharide and kaolin complexed Nanosponges for Hemorrhage control
Keywords:
Tamarindus indica, nanosponges, kaolin, hemostasis, polysaccharide, wound dressing, emulsion solvent diffusionAbstract
Uncontrolled bleeding continues to pose serious challenges in emergency trauma care, requiring the advancement of swift and powerful hemostatic agents. This report study investigated the development and assessment of nanosponges synthesized from Tamarindus indica seed polysaccharide complexed with kaolin, designed to achieve heightened hemostatic efficacy. The natural polysaccharide was extracted and refined, then crosslinked and combined with kaolin particles through the emulsion solvent diffusion method to fabricate porous, biocompatible nanosponges. The addition of kaolin, a recognized clot-promoting agent, enhances platelet activation and coagulation, while the polysaccharide framework offers structural support and biodegradability. Testing characterized the prepared nanosponges using FTIR, SEM, Porosity and swelling studies which providednoteworthy result. In vitro clotting experiments demonstrated considerably reduced clotting time, signifying productive hemostatic potential. HenceTamarindus indica seed polysaccharide-kaolin nanosponges represent a promising, natural-source, cost-effective solution for hemorrhage control which will benefit in clinical setting..
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Yang, Z.; Ye, T.; Ma, F.; Zhao, X.; Yang, L.; Dou, G.; Gan, H.; Wu, Z.; Zhu, X.; Gu, R.; et
al. Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control. Molecules 2022, 27, 2571. https://doi.org/10.3390/molecules27082571
Hemostatic Agents Ogle, Orrett E. et al.Dental Clinics, Volume 55, Issue 3, 433 – 439
R.Aubourg, J. Putzolu, S. Bouche, H. Galmiche, C. Denis, A. d’Andon, D. Maitrot, C. Partensky,Surgical hemostatic agents: Assessment of drugs and medical devices,Journal of Visceral Surgery,Volume 148, Issue 6,2011,Pages e405-e408,ISSN 1878-7886
Schonauer, C.; Tessitore, E.; Barbagallo, G.; Albanese, V.; Moraci, A. The use of local agents: Bone wax, gelatin, collagen, oxidized cellulose. Eur. Spine. J. 2004, 13, S89–S96. [CrossRef] [PubMed]
Agrawal, R., R. Gangurde, and K. Jadhav. "Nanosponges: an overview on processing, application and evaluation." World J Pharm Res 9.12 (2020): 273-87.
Akriti Nepal, Huong D.N. Tran, Nam-Trung Nguyen, Hang Thu Ta,Advances in haemostatic sponges: Characteristics and the underlying mechanisms for rapid haemostasis,Bioactive Materials,Volume 27,2023,Pages 231-256,ISSN 2452-199X
Chawananorasest, Khanittha, Patsuda Saengtongdee, and Praphakorn Kaemchantuek. "Extraction and characterization of tamarind (Tamarind indica L.) seed polysaccharides (TSP) from three difference sources." Molecules 21.6 (2016): 775.
Solunke, Rahul S., et al. "Formulation and evaluation of gliclazide nanosponges." Int J Appl Pharm 11.6 (2019): 181-189.
Tiwari, Kartik, and Sankha Bhattacharya. "The ascension of nanosponges as a drug delivery carrier: preparation, characterization, and applications." Journal of Materials Science: Materials in Medicine 33.3 (2022): 28.
Solunke, Rahul S., et al. "Formulation and evaluation of gliclazide nanosponges." Int J Appl Pharm 11.6 (2019): 181-189.
Richhariya, Neha, Sunil Kumar Prajapati, and Upendra Kumar Sharma. "Nanosponges: an innovative drug delivery system." World J Pharm Res 4.7 (2015): 1751-3.
Eissa, Rana A., et al. "Design of nanoconstructs that exhibit enhanced hemostatic efficiency and bioabsorbability." Nanoscale 14.30 (2022): 10738-10749.
Aung, Shine Htet, et al. "Comparison of functional properties of blood plasma collected from black goat and Hanwoo cattle." Food Science of Animal Resources 43.1 (2023): 46.
Sekhon, Ujjal Didar Singh, et al. "Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding." Science translational medicine 14.629 (2022): eabb8975.
Swaminathan, Shankar, et al. "Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity." European journal of pharmaceutics and biopharmaceutics 74.2 (2010): 193-201..
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