Formulation Development And Evaluation Of Solid Self-Nano Emulsifying Drug Delivery System Of Rosuvastatin Calcium
Keywords:
SNEDDS, Lipophillic, Emulsion, Isotropic, Dissolution rateAbstract
The primary aim of this current study is to establish an innovative Self Nano-Emulsifying Drug Delivery System (SNEDDS) to enhance the desired bioavailability and in vitro drug release, thereby amplifying the clinical effectiveness of orally administered drugs.SNEDDS is designed with the purpose of elevating the solubility of lipophilic or inadequately water-soluble drugs. It constitutes a blend of oil, surfactant, co-surfactant, and co-solvent, which amalgamate into an isotropic solution. This amalgam transforms into micro or nano-scale emulsions upon introduction into an aqueous environment with mild agitation. SNEDDS finds substantial utility in augmenting the solubility of drugs classified within the Bio-pharmaceutics classification system (BCS) class II and IV. It is particularly directed towards enhancing the solubility and bioavailability of poorly water-soluble drugs, with a focus on the Continuous-emulsification technique. SNEDDS emerges as a pioneering method in drug delivery, adaptable across diverse administration routes encompassing intravenous, ocular, intra-nasal, suppository, sustained-release oral formulations, pellets, and even cosmetic applications.
The implementation of SNEDDS remarkably accelerates the dissolution rate and diminishes interfacial tension. Upon dilution in aqueous media, such as gastrointestinal fluid, SNEDDS engenders a stable emulsion characterized by an oil-in-water (o/w) arrangement, featuring globule sizes measuring under 150 nanometers
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