An Overview on Nalbuphine

Authors

  • Samar Hamdy Ali Khalil
  • Ashraf Said Sayed Ahmed
  • Farahat Ibrahim Ahmed
  • Ahmed Beniamen Mohammed Hussein

Keywords:

Nalbuphine, opioid analgesic, κ-opioid agonist, μ-opioid antagonist, pain management, anesthesia

Abstract

Nalbuphine is a synthetic opioid analgesic with mixed agonist–antagonist activity, acting as a κ-opioid receptor agonist and a μ-opioid receptor antagonist. It has been widely used for the management of moderate to severe pain and as an adjunct in anesthesia. Compared with traditional opioids such as morphine, nalbuphine provides effective analgesia with a lower risk of respiratory depression, pruritus, and dependence, making it a valuable option in perioperative and postoperative settings

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Published

2025-09-22

How to Cite

1.
Ali Khalil SH, Sayed Ahmed AS, Ahmed FI, Mohammed Hussein AB. An Overview on Nalbuphine. J Neonatal Surg [Internet]. 2025Sep.22 [cited 2025Oct.9];13(1):1271-3. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/9187

Issue

Vol. 13 (2024): Journal of Neonatal Surgery

Section

Original Article

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