Correlation Between Hepatocyte Growth Factor Levels and Axial Length in Severe Myopic Patients
DOI:
https://doi.org/10.52783/jns.v14.1806Abstract
Background: Operative procedures have led to various side effects, including dry eyes, overcorrection, undercorrection, optical aberrations such as glare, ghost images, halos, and infections.
Objective: To analyze changes in plasma levels of hepatocyte growth factors (HGF) levels and their effects on the progression of axial length (AL) in severe myopia.
Method: This is a cross-sectional study that included all patients with severe myopia seeking treatment at USU Hospital.
Results: A total of 30 patients included in this study, with a mean HGF level of 1.17 ± 0.73 ng/mL. The left eye-AL (LE-AL) averaged 26.21 ± 0.14 mm, and the right eye-AL (RE-AL) averaged 26.17 ± 0.14 mm. Significant moderate positive correlations were found between HGF levels and both LE- AL (r = 0.479, p = 0.007) and RE-AL (r = 0.414, p = 0.023).
Conclusion: HGF levels are positively correlated with AL in patients with severe myopia. These suggest that HGF may play a role in the pathogenesis of axial elongation and could serve as a potential biomarker for monitoring disease progression in severe myopia.
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