Synthesis and characterization of new derivatives of CMC-g-PVA and evaluation pharmaceutical release, antibacterial activity, molecular docking
DOI:
https://doi.org/10.52783/jns.v14.1861Keywords:
Polyvinylalcoho, phathalicanhydride, Trimethoprim, Sodium, Fusidate, Hemayoxiline, chloramphenicol, phenylephrineAbstract
In this research drug polymers, have been prepared by substituting drugs to polymers backbone, which raised interest as a result of the benefits systems possesses, as the first part of a continued research on conversion of carboxymethyl cellulose- (CMC) to useful biopolymer-based materials, it possesses a plethora of other noteworthy attributes like biocompatibility, renewability, nontoxicity, and biodegradability, large numbers of hydroxyl functional groups were introduced onto CMC with different drugs (sulfamethoxazole , Salbutamol phenylephrin , Sodium Fusidate , Hemayoxiline , chloramphenicol ) by grafting with polyvinyl alcohol. Evidence of prepared compound was obtained by FTIR spectra, HMR, UV visible, the CMC-g-PVA copolymer was characterized thermally by using differential scanning calorimetry and thermogravimetric analysis methods. The biological activity of the prepared pharmaceutical polymers against two types of bacteria was also studied. The molecular bonding of some of the prepared polymers was also studied. The pharmaceutical degradation of some of them was studied in different acidic and alkaline media.
The controlled release for all polymers was studied in different pH=4, pH=9 values at (30-40)0C. The hydrolysis data showed that release rates are strongly dependent on the pH of the medium and temperature We concluded that the drug polymers could enhance the solubility of drug carrier polymers in water, with desirable properties, slow-release, and prolonged activity. These four methods of advanced properties and bearing of the different bioactive units, and studying Molecular Docking.
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Kumar B, Negi YS (2018) Water absorption and viscosity behaviour of thermally stable novel graft copolymer of carboxymethyl cellulose and poly(sodium 1-hydroxy acrylate). Carbohydr. Polym. 181: 862–870. https://doi.org/10.1016/j.carbpol.2017.11.066
Saha N, Shah R, Gupta P, Mandal BB, Alexandrova R, Sikiric MD, Saha P(2019) PVP-CMC hydrogel: An excellent bioinspired and biocompatible scaffold for osseointegration. Mater. Sci. Eng. 95: 440–449. https://doi.org/10.1016/j.msec.2018.04.050
Rahman MS, Hasan MS, Nitai AS, Nam S, Karmakar AK, Ahsan MS, Shiddiky MJA, Ahmed MB (2021) Recent Developments of Carboxymethyl Cellulose. Polymers. 13(8):1345. https://doi.org/10.3390/polym13081345
Elena-Emilia T, Cristina-Elena DN, Mădălina Georgiana AK, Lăcrămioara P, Valentina A, Mihai PR, Violeta GM (2021). An Overview of Cellulose Derivatives-Based Dressings for Wound-Healing Management. Pharmaceuticals. https://doi.org/10.3390/ph14121215
Jiamin W, Zhaoxue F, Chaohong D,Ping Z, Jianhui Q, Longxiang Z (2022) Synthesis of Sodium Carboxymethyl Cellulose/Poly(acrylic acid) Microgels via Visible-Light-Triggered Polymerization as a Self-Sedimentary Cationic Basic Dye Adsorbent. Langmuir. 38 (12):3711-3719.http://doi.org/10.1021/acs.Langmuir.1c03 196
Sirajudheen P, Karthikeyan P, Vigneshwaran S, Meenakshi S(2020) Synthesis and characterization of La (III) supported carboxymethylcellulose-clay composite for toxic dyes removal: Evaluation of adsorption kinetics, isotherms and thermodynamics. Int. J. Biol. Macromol. 161:1117–1126. https://doi.org/10.1016/j.ijbiomac.2020.06.103
Sirajudheen P, Nikitha MR, Karthikeyan P, Meenakshi S (2020) Perceptive removal of toxic azo dyes from water using magnetic Fe3O4 reinforced graphene oxide–carboxymethyl cellulose recyclable composite: Adsorption investigation of parametric studies and their mechanisms. Surf. Interfaces. 21:100648. http://doi.org/0.1016/j.surfin.2020.100648
Kong Q, Preis S, Li L, Luo P, Hu Y, Wei C (2020) Graphene oxide-terminated hyperbranched amino polymer-carboxymethyl cellulose ternary nanocomposite for efficient removal of heavy metals from aqueous solutions. Int. J. Biol. Macromol. 149: 581–592.mailto:DOI:10.1016/j.surfin.2020.100648
Zong P, Cao D, Cheng Y, Wang S, Zhang J, Guo Z, Hayat T, Alharbi NS, He C (2019) Carboxymethyl cellulose supported magnetic graphene oxide composites by plasma induced technique and their highly efficient removal of uranium ions. Cellulose. 26: 4039–4060.http://doi.org/10.1007/s10570-019-02358-4
Tanzifi M, Yaraki MT, Beiramzadeh Z, Saremi LH, Najafifard M, Moradi H, Mansouri M, Karami M, Bazgir H (2020) Carboxymethyl cellulose improved adsorption capacity of polypyrrole/CMC composite nanoparticles for removal of reactive dyes: Experimental optimization and DFT calculation. Chemosphere. 255: 127052. mailto:https://doi.org/10.1016/j.chemosphere.2020.127052
Godiya CB, Cheng X, Li D, Chen Z, Lu X (2019) Carboxymethyl cellulose/polyacrylamide composite hydrogel for cascaded treatment/reuse of heavy metal ions in wastewater. J. Hazard. Mater.364:28–38.http://doi.org/10.1016/j.jhazmat.2018.09.076
Janarthanan G, Tran HN, Cha E, Lee C, Das D, Noh I (2020) 3D printable and injectable lactoferrin-loaded carboxymethyl cellulose-glycol chitosan hydrogels for tissue engineering applications. Mater. Sci. Eng. C.113:111008.http://doi.org/ 10.1016/j.msec.2020.111008
Awad SH, Hussein FA, Mustafa SA (2021) Synthesis, Characterization of Poly (chitosan nano-particles-co-pyruvic acid) and Substitution with Different Amino Acids .International Journal of Drug Delivery Technology.11(4):1313–1317 . http://doi.org/10.25258/ijddt.11.4.32
Al-Sahib SA, Awad SH (2022) Synthesis, Characterization of Chitosan para- hydroxyl Benzaldehyde Schiff Base Linked Maleic Anhydride and the Evaluation of Its Antimicrobial Activities. Baghdad Science Journal.19(6):1265–1275. https://doi.org/10.21123/bsj.2022.5655
Liu B, Xu H, Zhao H, Wei L, Zhao L, Li Y (2016) Preparation and characterization of smart starch/PVA films for simultaneous colorimetric indication and antimicrobial activity for food packaging applications. Carbohydrate Polyme. https://doi.org/10.1016/j.carbpol.2016.10.067
Guzzo M, Simon N, Ye L, Motcho J, Bokanski B (2021) Improved release of poorly water-soluble drug by using electrospun water-soluble polymers as carriers Pharmacy.14(1):34. https://doi.org/10.3390/pharmaceutics14010034
Awad Sh, Hamood F, Kareem SASA. (2021) Synthesis and Characterization of Co-polymer of (Albumin-PVP) as Carriers for Different Antibiotics. Int J Drug Deliv Technol. 11(4): 137982 .http://doi.org/10.25258/ijddt.11.4.43
Daoud RD (2023) Determining the Ionization Constants of Some Schiff Bases Derived from Vanillin and Aniline and Its Substitutes by Spectrometric Titration Method.(Hammett Relation Application).Coll Basic Educ Res J.19 (1): 844-60. http:// doi.org /10.33899 /berj 2023.178143
Bufaroosha M, Salih N,Hadi AG, Ahmed SD, Al-mashhadani MH, Yousif E(2020) The Effect of UV Aging on the Structure of PVC in the Presence of Organotin (IV) Compounds. AL-Nahrain J. Sci. 23(1):5761. http://doi.org/10.22401/ANJS.23.1.08.
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