Thiopentone Sodium Vs Ketofol: A Comparative Study In Electroconvulsive Therapy

Authors

  • Harish. K
  • R. Prabhavathi
  • V. Jagadeesh
  • A. Rajitha
  • A. Charan Teja Reddy
  • K. Krishna Chaithanya

Keywords:

N\A

Abstract

BACKGROUND & AIM OF STUDY: We aim to compare THIOPENTONE SODIUM (TPS) and KETOFOL (a mixture of KETAMINE+PROPOFOL) as induction agents during ECT regarding their effects on ECT-induced hemodynamic changes, seizure duration and recovery parameters.

METHODS: 60 patients posted for electroconvulsive therapy (ECT) was allocated 30 each in two groups. Patient was premedicated with inj. glycopyrrolate 10 mcg/kg and induced with inj. Thiopentone sodium 3 mg/kg in Group A and Ketofol (Ketamine 0.5mg/kg + Propofol 0.5mg/kg) in Group B along with depolarizing muscle relaxant, inj. Succinyl choline 1mg/kg. Patient seizure duration, time for recovery, Richmond agitation sedation score, Modified Aldrete score, hemodynamics like heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, SPO2 were recorded at baseline and at 0 min, 3 min, 5 min, 10 min, 15 min, 20 min after induction. Parameters average was calculated and were compared by using chi-square test.

RESULTS: Seizure duration was better in Thiopentone sodium group(A) than Ketofol group(B) which was statistically significant with p=0.001.

Recovery time was better in Group B than Group A which was statistically significant with p=0.02. RASS, MAS were comparably better with Ketofol Group. Hemodynamics such as HR was significantly lesser in 3 min& 5 min with Group B(Ketofol). MAP was significantly lesser during induction& 20th min for group A(TPS).SPO2 was comparable in both groups. SBP at 0 min was lesser in Group A than Group B which was statistically significant. DBP at 10 min was lesser in group A than Group B which was statistically significant. In other minutes it was comparable between two groups.

CONCLUSION: Thiopentone sodium has significantly showed longer duration of seizure time. Ketofol showed significantly shorter duration of recovery time in patient undergone Electroconvulsive therapy.

Downloads

Download data is not yet available.

References

Gupta A, Bithal PK, Dash HH. Recovery characteristics of ketamine–propofol and thiopentone anaesthesia for electroconvulsive therapy: A comparative study. Indian J Anaesth. 2011;55(5):476–481.

Gurel SC, Ozden HC, Karahan S, Ayhan Y. The superiority of ketofol and etomidate against propofol or thiopental anaesthesia for ECT. Asian J Psychiatr. 2022 Jun;72:103090. doi:10.1016/j.ajp.2022.103090.

.Gaddam NR, Kelkar Sasturkar VP, Kulkarni SJ, Joshi PS, Bhale PV. A comparative study of propofol, thiopentone sodium, and ketofol as induction agents for electroconvulsive therapy. J Anaesthesiol Clin Pharmacol. 2021 Oct-Dec;37(4):554–560. doi:10.4103/joacp.JOACP_423_19.

.Wang X, Wang F, Wang L. Ketofol vs thiopental for anaesthesia in electroconvulsive therapy: A comparative study. J Anesth Clin Res. 2016;7(10):673

.Gupta A, Bithal PK, Dash HH. Recovery characteristics of ketamine–propofol and thiopentone anaesthesia for electroconvulsive therapy: A comparative study. Indian J Anaesth. 2011;55(5):476-481.

.Poojary SS, Surve RM, Bhargava AK. Hemodynamic effects of ketofol versus thiopentone during ECT: A randomized controlled trial. Saudi J Anaesth. 2019;13(2):109-114.

.Yalcin S, Aydoğan H, Karabakan G, et al. Comparison of ketofol and thiopental anaesthesia in electroconvulsive therapy: A randomized clinical study. Neuropsychiatr Dis Treat. 2015;11:1291–1296.

Kumar A, Rao NP, Chandrasekaran R, et al. Comparison of recovery and hemodynamic profiles of ketofol and thiopentone in ECT: A prospective study. Indian J Psychol Med. 2020;42(3):231–236.

Downloads

Published

2025-07-11

How to Cite

1.
Harish. K, Prabhavathi R, Jagadeesh V, Rajitha A, Teja Reddy AC, Chaithanya KK. Thiopentone Sodium Vs Ketofol: A Comparative Study In Electroconvulsive Therapy. J Neonatal Surg [Internet]. 2025Jul.11 [cited 2025Oct.31];14(32S):4875-84. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8207

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

  • Adapt — remix, transform, and build upon the material for any purpose, even commercially.

Terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.