Strategies to Prevent Healthcare-Associated Infections: Systematic Review
DOI:
https://doi.org/10.52783/jns.v14.2397Keywords:
prevention, hand hygiene, environmental hygiene, surveillance, antibiotic stewardshipAbstract
Healthcare-associated infections (HCAIs) represent a significant public health challenge and are associated with high burdens of illness and death worldwide. According to research, healthcare-associated infections (HCAIs) are estimated to affect seven per hundred hospitalized patients in high-income countries and ten in emerging and low-income countries. The increasing antimicrobial resistance among pathogens worse ns because very few new antimicrobial agents have entered the market. This article highlights different potential approaches to preventing the occurrence of HCAIs. It sets out how hand hygiene has been and continues to be a key preventative measure across the ages. HCAIs can be addressed through several methods, including keeping the hospital environment clean and enacting antibiotic stewardship programs.
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Haque M, McKimm J, Godman B, Abu Bakar M, Martelli M. Initiatives to reduce postoperative surgical site infections of the head and neck cancer surgery with a special emphasis on developing countries. Expert Rev Anticancer Ther. 2019;19(1):81–92. doi:10.1080/14737140.2019.1544497
Cassini A, Plachouras D, Eckmanns T, et al. The burden of six healthcare-associated infections on European population health: estimating incidence-based disability-adjusted life years through a population prevalence-based modeling study. PLoS Med. 2016;13(10):e1002150. doi:10.1371/journal.pmed.1002150
Ricchizzi E, Latour K, Kärki T, et al. Antimicrobial use in European long-term care facilities: results from the third point prevalence survey of healthcare-associated infections and antimicrobial use, 2016 to 2017. Euro Surveill. 2018;23(46):1800394. doi:10.2807/1560-7917.ES.2018.23.46.1800394
Ripabelli G, Salzo A, Mariano A, Sammarco ML, Tamburro M; Collaborative Group for HAIs Point Prevalence Surveys in Molise Region. Healthcare-associated infections point prevalence survey, and antimicrobials use in acute care hospitals (PPS 2016–2017) and long-term care facilities (HALT-3): a comprehensive report of the first experience in Molise Region, Central Italy, and targeted intervention strategies. J Infect Public Health. 2019;12(4):509–515.
Dye C. After 2015: infectious diseases in a new era of health and development. Philos Trans R Soc Lond B Biol Sci. 2014;369 (1645):20130426. doi:10.1098/rstb.2013.0426
Frieden TR. Six components are necessary for effective public health program implementation. Am J Public Health. 2014;104(1):17–22. doi:10.2105/AJPH.2013.301608
Adedeji WA. The treasure is called antibiotics. Ann Ib Postgrad Med. 2016;14(2):56-57.
Bianucci R, Benedict OJ, Fornaciari G, Giuffra V. Quinto Tiberio Angelerio and new measures for controlling plague in 16th-century Alghero, Sardinia. Emerg Infect Dis. 2013;19 (9):1478–1483. doi:10.3201/eid1909.120311
Alfani G, Murphy TE. Plague and lethal epidemics in the pre-industrial world. J Econ Hist. 2017;77(1):314–343. doi:10.1017/S0022050717000092
Institute of Medicine (US) Committee for the Study of the Future of Public Health. The future of public health. Washington (DC): National Academies Press (US); 1988. 3. A History of the Public Health System. Available from: https://www.ncbi.nlm.nih.gov/ books/NBK218224/. Accessed August 20, 2020.
Quinn SC, Kumar S. Health inequalities and infectious disease epidemics: a challenge for global health security. Biosecur Bioterror. 2014;12(5):263–273. doi:10.1089/bsp.2014.0032
Yi Y, Lagniton PNP, Ye S, Li E, Xu RH. COVID-19: what has been learned and to be learned about the novel coronavirus disease. Int J Biol Sci. 2020;16(10):1753–1766. doi:10.7150/ijbs.45134
Esfandiari A, Salari H, Rashidian A, Masoumi Asl H, Rahimi Foroushani A, Akbari Sari A. Eliminating healthcare-associated infections in Iran: a qualitative study to explore stakeholders’ views. Int J Health Policy Manag. 2017;7(1):27–34. doi:10.15171/ijhpm.2017.34
Martin M, Zingg W, Hansen S, et al.; PROHIBIT study group. Public reporting of healthcare-associated infection data in Europe. What are the views of infection prevention opinion leaders? J Hosp Infect. 2013;83(2):94–98. doi:10.1016/j.jhin.2012.10.010
Allegranzi B, Bagheri Nejad S, Combescure C, et al. The burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet. 2011;377 (9761):228–241. doi:10.1016/S0140-6736(10)61458-4
Esfandiari A, Rashidian A, Masoumi Asl H, Rahimi Foroushani A, Salari H, Akbari Sari A. Prevention and control of healthcare-associated infections in Iran: a qualitative study to explore challenges and barriers. Am J Infect Control. 2016;44 (10):1149–1153. doi:10.1016/j.ajic.2016.03.049
Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharm Ther. 2015;40(4):277–283.
Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global, multifaceted phenomenon. Pathog Glob Health. 2015;109(7):309–318. doi:10.1179/2047773215Y.0000000030
Paton J, Kresge N, GlaxoSmithKline. Big Pharma is leaving the field of antibiotic research in droves; 2018. Available from: https://www.busi less live.co.za/bd/companies/2018-07-13-big-pharma-is-leaving-the- field-of-antibiotic-research-in-droves/. Accessed February 12, 2019.
Sukkar E Why are there so few antibiotics in the research and development pipeline? The pharmaceutical journal. A Royal Pharmaceutical Society Publication; 2013. Available from: https:// www.pharmaceutical-journal.com/news-and-analysis/features/why- are-there-so-few-antibiotics-in-the-research-and-development- pipeline/11130209.article?firstPass=false. Accessed February 12, 2019.
Mathur P. Prevention of healthcare-associated infections in low- and middle-income countries: the 'bundle approach.' Indian J Med Microbiol. 2018;36(2):155–162. doi:10.4103/ijmm.IJMM_18_152
WHO Guidelines on Hand Hygiene in Health Care: First Global Patient Safety Challenge Clean Care is Safer Care. Geneva: World Health Organization; 2009. 4. Historical perspective on hand hygiene in health care. Available from: https://www.ncbi.nlm.nih. Gov/books/NBK144018/. Accessed February 14, 2019.
Semmelweis I. Etiology, Concept, and Prophylaxis of Childbed Fever. 1st. Carter KC, Madison WI. The University of Wisconsin Press; 1983
Lane HJ, Blum N, Fee E. Oliver Wendell Holmes (1809–1894) and Ignaz Philipp Semmelweis (1818–1865): preventing the transmission of puerperal fever. Am J Public Health. 2010;100 (6):1008–1009. doi:10.2105/AJPH.2009.185363
Labarraque AG. Instructions and Observations Regarding the Use of the Chlorides of Soda and Lime. Porter J, Transed [French]. New Haven, CT: Baldwin and Treadway; 1829.
Lowy EJL, Lilly HA, Bull JP. Disinfection of hands: removal of transient organism. Br Med J. 1964;2(5403):230–233. doi:10.1136/ bmj.2.5403.230
Sanford MD, Widmer AF, Bale MJ, Jones RN, Wenzel RP. Efficient detection and long-term persistence of the carriage of Methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 1994;19:1123–1128. doi:10.1093/clinids/19.6.1123
Rigby R, Pegram A, Woodward S. Hand decontamination in clinical practice: a review of the evidence. Br J Nurs. 2017;26 (8):448–451. doi:10.12968/bjon.2017.26.8.448
Maliwan H. Developing and Evaluating Effective Interventions to Reduce Healthcare-Associated Infection in A Resource-Limited Hospital in Thailand. Ph.D. Thesis. Mahidol Oxford Tropical Medicine Research Unit. The Open University; 2018. Available from: https://oro.open.ac.uk/55283/7/Thesis_Maliwan% 20Hongsuwan%2C%20B6976542.pdf. Accessed February 21, 2019
Larson EL, Cronquist AB, Whittier S, Lai L, Lyle CT, Della Latta P. Differences in skin flora between inpatients and chronically ill patients. Heart Lung. 2000;29:298–305. doi:10.1067/mhl.2000.108324
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