Pharmacological Evaluation of Epigallocatechin Gallate of Green Tea as Wound Healing Agent
Keywords:
Epigallocatechin Gallate, wound healing, antioxidant, anti-inflammation, angiogenesisAbstract
Green tea is characterized by the high content of polyphenols, which is produced from the tea plant Camellia sinensis. Epigallocatechin gallate (EGCG) is regarded as the most abundant compound in tea leaves with excellent bioactivities, such as antioxidant/free radical scavenging, anti-inflammatory and antimicrobial properties. However, the clinical application of EGCG is restricted by its low bioavailability, since EGCG is unstable under the alkalescent condition of the intestinal track and circulatory system. It was reported that a single injection of EGCG hardly accelerated the healing process of the wound on the back of rats. The potential application of EGCG to skin wound treatment has been investigated, and some positive results in vitro and in vivo have been achieved. The effects of EGCG on wound healing are associated with the application form and the dosage of EGCG, study models and treatment methods.
Downloads
Metrics
References
Millet A, Martin AR, Ronco C, Rocchi S, Benhida R. Metastatic melanoma: insights into the evolution of the treatments and future challenges. Medicinal Research Reviews. 2017: 37: 98 148.
Dummer R, Hauschild A, Lindenblatt N, Pentheroudakis G, Keilholz U. Cutaneous melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2015; 26: v126 v132.
Singh BP, Salama AKS. Updates in therapy for advanced melanoma. Cancers. 2016; 8(1): article 17.
Hodi FS SJ, McDermott DT, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. The New England Journal of Medicine. 2010; 363(8): 711 723.
Micali G, Lacarrubba F, Bhatt K, Nasca MR. Medical approaches to non- melanoma skin cancer. Expert Rev Anticancer Ther. 2013; 13:1409-21.
Amaral T, Garbe C. Non-melanoma skin cancer: New and future synthetic drug treatments. Expert Opin Pharmacother. 2017; 18:689-99.
Kim JYS, Kozlow JH, Mittal B, Moyer J, Olencki T, Rodgers P. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol. 2018; 78(3): 540 559.
Swetter SM, Tsao H, Bichakjian CK, Curiel-Lewandrowski C, Elder DE, Gershenwald JE, et al. Guidelines of care for the management of primary cutaneous melanoma. J Am Acad Dermatol. 2019; 80(1): 208 250
Kim JYS, Kozlow JH, Mittal B, Moyer J, Olencki T, Rodgers P. Guidelines of care for the management of cutaneous squamous cell carcinoma. J Am Acad Dermatol. 20108; 78(3): 560 578.
Dubas LE, Ingraffea A. Nonmelanoma skin cancer. Facial Plast Surg Clin N Am. 2013; 21(1):43 53.
Gracia-Cazana T, Gonzalez S, Gilaberte Y. Resistance of nonmelanoma skin cancer to nonsurgical treatments. Part I: topical treatments. Actas Dermo- Sifiliográficas (Engl Ed). 2016; 107(9):730 739.
Dianzani C, Zara CP, Maina G, Pettazonni P, Pizziment S, Rossi F, Gigliotti CL, et al. Drug Delivery Nanoparticles in Skin Cancers. Biomed Res Int. 2014; 2014: 895986.
Allen TM, Cullis PR. Drug Delivery Systems: Entering the Mainstream. Science. 2004; 303(5665): 1818 1822.
Emerich DF, Thanos CG. The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis. Biomolecular Engineering. 2006; 23(4):171 184.
Orthaber K, Pristovnik M, Skok K, Perik B, Maver U. Skin Cancer and Its Treatment: Novel Treatment Approaches with Emphasis on Nanotechnology. Journal of Nanomaterials. 2017; 2606271.
Chuang SY, Lin CH, Huang TH, Fang JY. Lipid based nanoparticles as a potential delivery approach in the treatment of rheumatoid arthritis. Nanomaterials. 2018; 8(1): 42.
Barros SM, Whitaker SK, Sukthankar P, Avila LA, Gudlur S, Warner M, et al. A review of solute encapsulating nanoparticles used as delivery systems with emphasis on branched amphipathic peptide capsules. Arch Biochem Biophys. 2016; 596: 22 42.
Yang Y. Development of a mesoporous silica based nanosystem for safe and efficient therapeutic delivery. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. 2019.
Rajan R, Jose S, Mukund VB, Vasudevan DT. Transferosomes-A vesicular transdermal delivery system for enhanced drug permeation. J Adv Pharm Technol Res. 2011; 2(3): 138 143.
Rai S, Pandey V, Rai G. Transfersomes as versatile and flexible nano- vesicular carriers in skin cancer therapy: The state of the art. NanoReviews & Experiments. 2017; 8(1): 1325708.
Patel D, Chatterjee B. Identifying underlying issues related to the inactive excipients of transfersomes based drug delivery system. Curr Pharm Des. 2020; 27(7): 971 980.
Hallan SS, Sguizzato M, Mariani P, Cortesi R, Huang N, Simelière F,Marchetti N, DrechslerM, Ruzgas T, Esposito E. Design and characterization of ethosomes for transdermal delivery of caffeic acid. Pharmaceutics. 2020; 12(8): 740.
Ashtikar M, Nagarsekar K, Fahr A. Transdermal delivery from liposomal formulations evolution of the technology over the last three decades. J Controlled Release. 2016; 242: 126 140.
Thi TTH, Suys EJ, Lee JS, Nguyen DH, Park KD, Truong NP. Lipid-Based nanoparticles in the clinic and clinical trials: from cancer nanomedicine to COVID-19 vaccines. 2021
Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. Aaps Pharmscitech. 2011; 12(1):62 76.
Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Adv Pharm Bull. 2015; 5(3): 305 313.
. Nanostructured lipid carriers (NLCs) for drug delivery: role of liquid lipid (Oil). Curr Drug Delivery. 2020; 18(3): 249 270.
Fang C-L, A Al-Suwayeh S, Fang J-Y. Nanostructured lipid carriers (NLCs) for drug delivery and targeting. Recent Pat Nanotechnol. 2013; 7(1): 41 55.
Bhattacharya S. Fabrication and characterization of chitosan-based polymeric nanoparticles of imatinib for colorectal cancer targeting application. Int J Biol Macromol. 2020; 151: 104 115.
Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release. Chem Rev. 2016; 116(4): 2602 2663.
Rai R, Alwani S, Badea I. Polymeric nanoparticles in gene therapy: New avenues of design and optimization for delivery applications. Polymers (Basel). 2019; 11(4): 745.
Kassem AA, El-Alim A, Hosam S. Vesicular Nanocarriers: a potential platform for dermal and transdermal drug delivery. In: Nanopharmaceuticals: Principles and Applications. Cham: Springer. 2021; 8: 155 209.
Dave K, Krishna Venuganti VV. Dendritic polymers for dermal drug delivery. Ther Delivery. 2017; 8(12): 1077 1096.
Mahmoud NN, Alhusban AA, Ali JI, Al-Bakri AG, Hamed R, Khalil EA. Preferential accumulation of phospholipid- PEG and cholesterol-PEG decorated gold nanorods into human skin layers and their photothermal- based antibacterial activity. Sci Rep. 2019; 9(1): 1 15.
Ahmad MZ, Rizwanullah M, Ahmad J, Alasmary MY, Akhter MH, Abdel- Wahab BA, et al. Progress in nanomedicine-based drug delivery in designing of chitosan nanoparticles for cancer therapy. International Journal of Polymeric Materials and Polymeric Biomaterials. 2022; 71(8): 602 623.
Riehemann K, Schneider SW, Luger TA, Godin B, Ferrari M, Fuchs H. Nanomedicine challenge and perspectives. Angew Chem, Int Ed. 2009; 48(5): 872 897.
Lizeth A, López A, Avalos PY, Martinez SA, Sanchez CO, Villegas SM et al. Influence of erbium doping on zinc oxide nanoparticles: structural, optical and antimicrobial activity. Appl Surf Sci. 2022; 575: 151764.
Patra CR, Bhattacharya R, Mukhopadhyay D, Mukherjee P. Fabrication of gold nanoparticles for targeted therapy in pancreatic cancer. Adv Drug Delivery Rev. 2010; 62(3): 346 361.
Parchur AK, Sharma G, Jagtap JM, Gogineni VR, LaViolette PS, FlisterMJ, et al. Vascular interventional radiology-guided photothermal therapy of colorectal cancer liver metastasis with theranostic gold nanorods. ACS Nano. 2018; 12(7): 6597 6611.
Gessner I, Neundorf I. Nanoparticles Modified with Cell-Penetrating Peptides: Conjugation Mechanisms, Physicochemical Properties, and Application in Cancer Diagnosis and Therapy. International Journal of Molecular Sciences. 2020; 21(7):2536.
Ni Y, Wang R, Zhang W, Shi S, Zhu W, Liu M, et al. Graphitic carbon nitride (g-C3N4)-based nanostructured materials for photodynamic inactivation: synthesis, efficacy andmechanism. Chem Eng J. 2020; 404: 126528.
He H, Pham-Huy LA, Dramou P, Xiao D, Zuo P, Pham-Huy C. Carbon nanotubes: applications in pharmacy and medicine. BioMed Res Int. 2013: 578290.
Erathodiyil N, Ying JY. Functionalization of inorganic nanoparticles for bioimaging applications. Acc Chem Res. 2011; 44(10): 925 935.
.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
