Artificial Intelligence And Advanced Vascular Imaging: Emerging Tools For Precision In Peripheral Arterial Disease Management
Abstract
Background: Peripheral arterial disease (PAD) is a growing global health issue, often underdiagnosed due to limitations in conventional imaging. Artificial intelligence (AI) offers new opportunities to improve PAD diagnosis and management.
Methods: This review summarizes recent advances in vascular imaging—such as duplex ultrasound, CTA, MRA, and intravascular modalities—and the integration of AI methods like machine learning and deep learning to enhance image interpretation and clinical decision-making.
Results: AI has shown high accuracy in detecting PAD lesions, automating plaque assessment, and predicting outcomes. These tools can match or exceed expert performance, yet real-world implementation faces barriers, especially in low-resource settings.
Conclusions: AI-enhanced imaging has strong potential to transform PAD care through more accurate, personalized diagnosis and treatment. Broader adoption will require addressing technical, regulatory, and infrastructure challenges
Downloads
Metrics
References
Lareyre F, Behrendt CA, Chaudhuri A, Lee R, Carrier M, Adam C, et al. Applications of artificial intelligence for patients with peripheral artery disease. J Vasc Surg. 2023 Feb;77(2):650-658.e1.
Yan C, Chen J, Xu X, Wei H, Li J. Global burden of peripheral arterial disease (1990–2021), global burden trends and the impact of blood lead on peripheral arterial disease: a multidimensional analysis based on NHANES, GBD, and Mendelian randomization. J Transl Med. 2025 Apr 23;23(1):463.
Flores AM, Demsas F, Leeper NJ, Ross EG. Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes. Circ Res. 2021 Jun 11;128(12):1833–50.
Horváth L, Németh N, Fehér G, Kívés Z, Endrei D, Boncz I. Epidemiology of Peripheral Artery Disease: Narrative Review. Life. 2022 Jul 12;12(7):1041.
Kim MS, Hwang J, Yon DK, Lee SW, Jung SY, Park S, et al. Global burden of peripheral artery disease and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Glob Health. 2023 Oct;11(10):e1553–65.
Adou C, Magne J, Gazere N, Aouida M, Chastaingt L, Aboyans V. Global epidemiology of lower extremity artery disease in the 21st century (2000–21): a systematic review and meta-analysis. Eur J Prev Cardiol. 2024 May 11;31(7):803–11.
Abola MTB, Golledge J, Miyata T, Rha SW, Yan BP, Dy TC, et al. Asia-Pacific Consensus Statement on the Management of Peripheral Artery Disease: A Report from the Asian Pacific Society of Atherosclerosis and Vascular Disease Asia-Pacific Peripheral Artery Disease Consensus Statement Project Committee. J Atheroscler Thromb. 2020 Aug 1;27(8):809–907.
Gao X, Tong Z, Wu Y, Guo L, Gu Y, Dardik A. Similarities and differences in peripheral artery disease between China and Western countries. J Vasc Surg. 2021 Oct;74(4):1417-1424.e1.
Hashemi-Madani N, Khamseh ME. Screening of Peripheral Arterial Disease in People with Type 2 Diabetes Mellitus – A Commentary Article. J Diabetes Clin Res. 2021 Sep 27;3(3).
Csore J, Drake M, Roy TL. Peripheral arterial disease treatment planning using noninvasive and invasive imaging methods. Journal of Vascular Surgery Cases, Innovations and Techniques. 2023 Dec;9(4):101263.
Parwani D, Ahmed MA, Mahawar A, Gorantla VR. Peripheral Arterial Disease: A Narrative Review. Cureus. 2023 Jun 11;
Stacy MR. Molecular Imaging of Lower Extremity Peripheral Arterial Disease: An Emerging Field in Nuclear Medicine. Front Med (Lausanne). 2022 Jan 12;8.
Caranovic M, Kempf J, Li Y, Regensburger AP, Günther JS, Träger AP, et al. Derivation and validation of a non-invasive optoacoustic imaging biomarker for detection of patients with intermittent claudication. Communications Medicine. 2025 Mar 25;5(1):88.
Flores AM, Demsas F, Leeper NJ, Ross EG. Leveraging Machine Learning and Artificial Intelligence to Improve Peripheral Artery Disease Detection, Treatment, and Outcomes. Circ Res. 2021 Jun 11;128(12):1833–50.
Martelli E, Capoccia L, Di Francesco M, Cavallo E, Pezzulla MG, Giudice G, et al. Current Applications and Future Perspectives of Artificial and Biomimetic Intelligence in Vascular Surgery and Peripheral Artery Disease. Biomimetics. 2024 Aug 1;9(8):465.
Bagheri Rajeoni A, Pederson B, Clair DG, Lessner SM, Valafar H. Automated Measurement of Vascular Calcification in Femoral Endarterectomy Patients Using Deep Learning. Diagnostics. 2023 Nov 1;13(21):3363.
Song JH, Tomihama RT, Roh D, Cabrera A, Dardik A, Kiang SC. Leveraging Artificial Intelligence to Optimize the Care of Peripheral Artery Disease Patients. Ann Vasc Surg. 2024 Oct;107:48–54.
Perez S, Thandra S, Mellah I, Kraemer L, Ross E. Machine Learning in Vascular Medicine: Optimizing Clinical Strategies for Peripheral Artery Disease. Curr Cardiovasc Risk Rep. 2024 Dec 4;18(12):187–95.
Li B, Aljabri B, Verma R, Beaton D, Hussain MA, Lee DS, et al. Predicting Outcomes Following Lower Extremity Endovascular Revascularization Using Machine Learning. J Am Heart Assoc. 2024 May 7;13(9).
Yao PF, Diao YD, McMullen EP, Manka M, Murphy J, Lin C. Predicting amputation using machine learning: A systematic review. PLoS One. 2023 Nov 7;18(11):e0293684.
Reddy S, Shaikh S. The long road ahead: navigating obstacles and building bridges for clinical integration of artificial intelligence technologies. J Med Artif Intell. 2025 Mar;8:7–7.
Guleria S, Guptill J, Kumar I, McClintic M, Rojas JC. Artificial intelligence integration in healthcare: perspectives and trends in a survey of U.S. health system leaders. BMC Digital Health. 2024 Nov 19;2(1):80.
Pongtriang P, Rakhab A, Bian J, Guo Y, Maitree K. Challenges in Adopting Artificial Intelligence to Improve Healthcare Systems and Outcomes in Thailand. Healthc Inform Res. 2023 Jul 31;29(3):280–2.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Ryan Prasdinar Pratama Putra, Yan Efrata Sembiring

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.