Interleukin-6 Level In Vivo And In Vitro Anti Inflammatory and Anti-Pyretic Evaluation of Aloe Vera Ethanolic Extract in Sprague Dawley

Authors

  • Solihati
  • Mohd Hijaz Mohd Sani
  • Fong Siat Yee Alison
  • Hartanto Mulyo

Keywords:

Interleukin-6, granuloma formation, cotton pellet-induced, Aloe Vera extract

Abstract

Aloe vera has been extensively used in cosmetic applications. Aloe vera has anti-inflammatory, antipyretic and antioxidant effects.

Objective: to correlate the anti-inflammatory & antipyretic effect of Aloe vera ethanolic extract (AVEE) in vivo and in vitro models in rats in the interleukin-6 level.

Methods: a true experimental design with randomized approach included 25 male Sprague-Dawley rats. Separation and purification of each secondary metabolite of AVEE by phytochemical screening at the University of Indonesia laboratory. Rat paw edema was induced with cotton pellet-induced granuloma formation and IL-6 level. Efficacy of aloe vera was analyzed using ANOVA by SPSS v.27.0. the p-value for statistical significance was defined as p<0.01

Results: AVEE effective reduced granuloma tissue formation and protected granuloma through inflammation induced by cotton pellets and histological examination at 200 mg/kg BW. The effective concentration that effect IL6 concentration is 200 mg/kgBW AVEE and statistically significant(P<0.01).

Conclusion: Aloe Vera Ethanolic Extract (AVEE) has anti-inflammatory and antipyretic activity in rats, altrough no significant to activity antipyretic in rats.

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Published

2025-05-08

How to Cite

1.
Solihati S, Hijaz Mohd Sani M, Siat Yee Alison F, Mulyo H. Interleukin-6 Level In Vivo And In Vitro Anti Inflammatory and Anti-Pyretic Evaluation of Aloe Vera Ethanolic Extract in Sprague Dawley. J Neonatal Surg [Internet]. 2025May8 [cited 2025Sep.15];14(21S):707-13. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/5383

Issue

Vol. 14 No. 21S (2025): Journal of Neonatal Surgery

Section

Original Article

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