Review On Floating Microspheres: A Novel Approach

Authors

  • Babita
  • Vandana Sahani
  • Shivanand Patil

Keywords:

Floating microsphere, Gastric retention tim, Bioavailability, Sustained release, Delayed release, Absorption, Microsphere, Drug delivery

Abstract

The purpose of floating microsphere's is to improve gastric retention time. Floating drug delivery is considered as the most effective amongst the several approaches of gastro retentive drug delivery systems. The short gastric residence times (GRT) and unpredictable gastric emptying times (GET) are the two most important parameters that play a vital role in improving the bioavailability of drugs those are having an absorption window at the stomach. The purpose of writing this review on floating microspheres is to compile the recent literature with special focus on the principle mechanism of floatation to achieve gastric retention.  Recent advances indicate that floating microspheres are especially suitable for achieving sustained or delayed release oral formulations with flexibility of blending to attain different release patterns, low risk of dose dumping as well as reproducible and short gastric retention time. The floating drug delivery approach is a low-density system that may be effervescent or Non - Effervescent type with sufficient buoyancy to flow over the gastric contents and remain buoyant in the stomach without affecting the stomachic emptying rate for a prolonged duration. Floating dosage forms include tablets, granules, capsules, microspheres, microparticle, etc. are few formulations available commercially. A comprehensive summary of different floating drug delivery and its present status has been highlighted in this review.

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References

Bhise M , Shukla K , Jain S, Bhajipale N, Sudke S , Burakle P. Development and Evaluation of Floating Microspheres of Anticonvulsant Drug by 32 Full Factorial Design. Turk J Pharm Sci. 2022 Oct 31;19(5):595-602.

Lalit Kumar1 Abhishek Sharma , Gastro Retentive Floating Microsphere, A Review Journal of Pharmaceutical Science and Bioscientific Research 2019. 9 (2):142-148

Deb J., Venkateswarlu B.S., Ghosh A, Choudhuri , Paul P, Faizi M, Asian Journal of Biomedical and Pharmaceutical Sciences 1 (2) 2011, 11-19

Fmith Celvia Miranda, Krishnananda Kamath K., and A. R. Shabaraya , Floating Microspheres: A Review World Journal of Pharmacy and Pharmaceutical Sciences 2019;8(7)

Sharma AR and Afroz Khan: Gastroretentive Drug Delivery System, An approach to enhance Gastric retention for prolonged drug release. Int J Pharm Sci Res 2014; 5(4): 1095-06.

Aniket Uttam Pund , Raosaheb Sopanrao Shendge , Ajinkya Kailas Pote , Current Approaches on Gastroretentive Drug Delivery systems Journal of Drug Delivery & Therapeutics. 2020; 10(1):139-146

Nisha Sharma, Neha Purwar, and Prakash Chandra Gupta, Microspheres as drug carriers for controlled drug delivery: A Review. IJPSR, 2015; 6(11): 4579-4587

Mishra A, Rathore S, Marothia D, Chauhan CS (2018), Formulation and Evaluation of Floating Microspheres of an Anti-Diabetic Agent. Int J Drug Dev & Res 10: 7-11

Anuradha A. Birajdar, Madhuri T. Deshmukh, Rajkumar V. Shete, A Review on Gastro-Retentive Floating Microspheres Journal of Drug Delivery & Therapeutics. 2021; 11(1-s):131-138.

Grandhi Srikar, Dadi Shanthi, J. Ramesh, V. Kalyani, I. Nagamma, Floating Microspheres: A Prevailing Trend in the Development of Gastroretentive Drug Delivery System. Asian Journal of Pharmaceutics 2018;12 (4):235-242

Gholap SB, Bannerjee SK , Gaikwad DD, Jadhav SL, Thorat RM. Hollow microsphere: A review. Int J Pharm Sci Res. 2010; 1(1):74-79.

Singh BN, Kim KH. Floating drug delivery system: Approach to oral controlled drug delivery via gastric retention. J Control Rel. 2000; 63: 235-259.

Dave, B. S., Amin, A. F., & Patel, M. M. (2004). Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation. Aaps PharmSciTech, 5(2), 77-82.

Reddy VS, Badarinath AV, Prakash KG., Formulation and evaluation of floating tablets of ciprofloxacin hydrochloride. Asian Journal of Pharmaceutics , 12(2): 106-113,(2018).

Saritha D, Sathish D and Rao YM., Formulation and evaluation of gastroretentive floating tablets of domperidone maleate. Journal of Applied Pharmaceutical Science, 3: 68-73,(2012).

Patial K, Dua JS, Menra M and Prasad DN., A review: Floating drug delivery system. World Journal of Pharmaceutical Research,6: 614-633,(2016).

Prasad BSG, Gupta VRM, Devanna N, Jayasurya K. Microspheres as Drug Delivery System – A Review. 2014 5(3): 1961-19.

Mukherjee S., Bandyopadhyay P. Magnetic microspheres: A latest approach in novel drug delivery system, JPSI. 2012; 1(5): 21-25.

Shah S, Patel J, Pate N. Stomach Specific Floating Drug Delivery System. Int J Pharm Tech Res 2009;1(3):623-633.

Kristal J, Vreer F, Zorko B. Optimisation of Floating Matrix Tablet and Evaluation of their Gastric Residence Time. Int J Pharm. 2000; 1(95): 125 – 130.

Chien YW. Rate-controlled Drug Delivery Systems. Ind J Pharm Sci. 1988; 63-65.

Ishwarya M, Ramu S, Kumar S. Floating Microspheres a Promising Drug Delivery. Int J Pharm and Pharma Res.2017; 11 (1): 375-388.

Rathor S, Ram A. Porous Microspheres of 5- Fluorouracil for Site Specific Drug Delivery System. Int J Pharma Res. 2011; 3(1): 38-42.

Nidhi P, Anamika C, Twinkle S, Mehul S, Hitesh J, Umesh U. Controlled drug delivery system: A review. Indo Am J Pharm Sci 2016;3:227-33.

Prasad BS, Gupta VR, Devanna N, Jayasurya K. Microspheres as drug delivery system-a review. J Glob Trends Pharm Sci 2014;5:1961-72.

Dutta P, Sruti J, Niranajan P, Bhanoji MER. Floating Microspheres: Recent trends in the development of gastroretentive floating drug delivery system. Int J of Pharm Sci and Nanotech, 2011; 4(1): 1296-1306.

Faraz J, Sunil K, Saurabh S, Prabhakar V, Lalit S. Review on stomach specific drug delivery systems: Development and Evaluation. Int J of Res in Pharm and Biomed Sci, 2011; 2(4): 1427-33. 3. Jagtap YM, Bhujbal RK, Ranpise NS. Floating microspheres: A Review. Braz J Pharm Sci, 2012; 48(1): 18-30.

Patel N. Floating drug delivery system: An innovative approach to prolong gastric retention, 2007.

Shah SH, Patel JK, Patel NV. Stomach specific floating drug delivery system: A Review. Int J of PharmTech Res, 2009; 1(3): 623-33.

Kumar A. Floating Microspheres of Cimetidine: Formulation, Characterization and In vitro Evaluation. Acta Pharm. 2005; 55:277–285.

A. Anka Rao, Narender. Malothu , A. Narayana Rao, Bandaru Naga Raju, B. Jahasultana. 33.Mohammed. Formulation and Evaluation of Floating Microspheres of Sitagliptin. Research Journal of Pharmacy and Technology 2023; 16(5):2251-6.

Mukund, J. Y., Kantilal, B. R., & Sudhakar, R. N. (2012). Floating microspheres: a review. Brazilian Journal of Pharmaceutical Sciences, 48, 17-30. 2) Janjale, V. R., Patil, S. R., & Fegade, T. D. (2020). A Review on: Floating Microsphere. American Journal of Pharmaceutical Research, 10(02), 232-59. 3).

Dighe, D. A., Choudhary, N. H., Thorat, M. S., Vir, P. R., Kumbhar, M. S., & Singh, M. C. (2012). Floating drug delivery system: A novel approach towards gastro retention. International Journal of Pharmaceutical and Chemical Science, 1(3), 779- 793. 4).

Jain, N. K. (Ed.). (1997). Controlled and novel drug delivery (pp. 236-237). New Delhi: CBS publishers & distributors.

Singh, A. kumar. Role of Natural Polymers Used In Floating Drug Delivery System. J. Pharm. Sci. Innov, June, 2012; 1:11–15.

Karosiya SR, Vaidya VM, Bhajipale NS, Radke RS. Formulation and Evaluation of Gastroretentive Floating Microspheres loaded with Lamivudine. J. Drug Delivery Ther. [Internet]. 2022 Aug. 15 [cited 2025 Apr. 15];12(4-S):17-22.

Shankar NB, Kumar NU. Lamivudine loaded Microspheres for oral use: Design development and establishment of In-Vivo-In-Vitro correlation. Asian Journal of Pharma and Clinical Research. 2009;2(1):55-60.

Nayak AK, Malakar J, Sen KK. Gastro-retentive drug delivery technologies: Current approaches and future potential. J Pharm Educ Res. 2010;1(2):1-12.

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Published

2025-05-24

How to Cite

1.
Babita B, Sahani V, Patil S. Review On Floating Microspheres: A Novel Approach. J Neonatal Surg [Internet]. 2025May24 [cited 2025Oct.6];14(27S):408-19. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/6449

Issue

Vol. 14 No. 27S (2025): Journal of Neonatal Surgery

Section

Original Article

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