Development and Evaluation of Gastro-retentive Floating Microspheres Containing Ranitidine Hydrochloride with Natural Polymers Tamarindus indica and Trigonella foenum-graecum

Authors

  • Babita
  • Vandana Sahani
  • Shivanand Patil

Keywords:

Floating microsphere, Gastric retention time, Bioavailability, Sustained release, Absorption, Microsphere, Drug delivery, Floating drug delivery, Gastric acid

Abstract

The aim of this study was to formulate and evaluate floating microspheres of Ranitidine Hydrochloride. This formulation mainly used for inhibition of Gastric acid secretion. In the present study, preparation of ranitidine floating microspheres, evaluation of Floating Drug Delivery System (FDDS) in vitro, prediction of the release, and optimization of stirring speed and polymers ratio to match target release profile was investigated. Floating microspheres were prepared by Cross- linking emulsification method using Tamarind indica, Eudragit RS 100, Trigonella foenum graecum  for mucoadhesive and as rate controlling polymer targeted drug delivery or to create protective barriers within the stomach. Floating drug delivery is considered as the most effective amongst the several approaches of gastro retentive drug delivery systems. The short gastric residence times (GRT) and unpredictable gastric emptying times (GET) are the two most important parameters that play a vital role in improving the bioavailability of drugs those are having an absorption window at the stomach. The gastric contents and remain buoyant in the stomach without affecting the stomachic emptying rate for a prolonged duration. The developed floating microspheres of ranitidine may be used in clinic for prolonged drug release in stomach there by improving the bioavailability.

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Published

2025-07-07

How to Cite

1.
Babita B, Sahani V, Patil S. Development and Evaluation of Gastro-retentive Floating Microspheres Containing Ranitidine Hydrochloride with Natural Polymers Tamarindus indica and Trigonella foenum-graecum. J Neonatal Surg [Internet]. 2025Jul.7 [cited 2025Oct.13];14(32S):4040-5. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8063

Issue

Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

Section

Original Article

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