Formulation and characterization of Methyl Eugenol Nanocapsules
Keywords:
Nanocapsules, methyl Eugenol, Neuroprotectants, DSC, FTIR, Release kinetics etcAbstract
Alzheimer's disease (AD) is a neurodegenerative brain disorder that affects memory, thinking, concentration, and judgment, ultimately hindering a person's ability to perform routine daily activities. It is characterized by progressive memory loss, language deficits, depression, agitation, mood disturbances and psychosis.
On the other hand, it supports the use of herbal medicines due to their nonspecific antioxidant and anti-inflammatory activity and specific cholinesterase inhibitory activity. The popularity of herbal medicines is also increasing due to their perceived effectiveness, safety and affordability. Methyl Eugenol and terpinol are polyphenolic flavonoid that possesses various neuroprotective effects by attenuating the levels of AChE enzyme, accumulated amyloid β, free radicals and neuroinflammation against Alzheimer's disease (AD). Controlled drug release, increased stability of volatile components, active biodegradable packaging and site-specific drug delivery are important areas of this study. Nanocapsules (NCs) are microscopic spherical shells consisting of a core (liquid or solid) in which the drug is enclosed in a cavity by a characteristic polymer membrane. Different methods are used to obtain Nano capsules, but interphase polymerization methods, Nano deposition for a preformed polymer, polymer coating method are mainly preferred. The most important properties in their preparation are particle size and size distribution, which can be evaluated using various techniques such as FTIR, scanning electron microscopy (SEM), DSC, Zeta potential . Nanocapsules with extremely high reproducibility have a wide range of applications in life sciences. They can be used in genetic engineering, cosmetics, cleaning products, wastewater treatment, application of adhesive components, cancer therapy, neuroprotective activity, nano capsule bandages to fight infection, radiotherapy, and as liposomal nano capsules in food science and agriculture. Improved delivery of bioactive molecules through targeted delivery using nano capsules presents many challenges and opportunities for research and future development of new advanced therapies.
Downloads
Metrics
References
Haotian Sun 1, William Erdman III 2 et al..,Crosslinked Polymer Nanocapsules for Therapeutic, Diagnostic, and Theranostic Applications, Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020 Jul 3;12(6):e1653. doi: 10.1002/wnan.1653
Sun H, Yan L, Carter KA, Zhang J, Caserto JS, Lovell JF, … & Cheng C (2019). Zwitterionic Cross-Linked Biodegradable Nanocapsules for Cancer Imaging. Langmuir, 35(5), 1440–1449. 10.1021/acs.langmuir.8b01633 [DOI] [PMC free article] [PubMed] [Google Scholar]
Sun H, Yarovoy I, Capeling M, & Cheng C (2017). Polymers in the co-delivery of siRNA and anticancer drugs for the treatment of drug-resistant cancers. Topics in Current Chemistry, 375, 24. 10.1007/s41061-017-0113-z [DOI] [PubMed] [Google Scholar]
Taheri S, Baier G, Majewski P, Barton M, Förch R, Landfester K, & Vasilev K (2014). Synthesis and antibacterial properties of a hybrid of silver–potato starch nanocapsules by miniemulsion/polyaddition polymerization. Journal of Materials Chemistry B, 2(13), 1838–1845. 10.1039/C3TB21690J [DOI] [PubMed] [Google Scholar]
Taylor-Pashow KM, Della Rocca J, Huxford RC, & Lin W (2010). Hybrid nanomaterials for biomedical applications. Chemical Communications, 46(32), 5832–5849. 10.1039/C002073G [DOI] [PubMed] [Google Scholar]
Tian H, Du J, Wen J, Liu Y, Montgomery SR, Scott TP, … & Lu Y (2016). Growth-factor nanocapsules that enable tunable controlled release for bone regeneration. ACS Nano, 10(8), 7362–7369. 10.1021/acsnano.5b07950 [DOI] [PubMed] [Google Scholar]
Tian K, Zeng J, Zhao X, Liu L, Jia X, & Liu P (2015). Synthesis of multi-functional nanocapsules via interfacial AGET ATRP in miniemulsion for tumor micro-environment responsive drug delivery. Colloids and Surfaces B: Biointerfaces, 134, 188–195. 10.1016/j.colsurfb.2015.06.057 [DOI] [PubMed] [Google Scholar]
Arpita Samanta1*, Bidyut Bandyopadhyay1 and Nirmalendu Das2 Samanta A, Bandyopadhyay B, Das N ,Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability. Med chem (Los Angeles) 6: 399-404,2016.
Mario D.L. Moretti, Giovanni Sanna-Passino, Stefania Demontis, and Emanuela Bazzoni , Essential Oil Formulations Useful as a New Tool for Insect Pest Control 2002.
Ricardo M. González-Reza 1,2 , Humberto Hernández-Sánchez 1 , David Quintanar- Guerrero 3 , Liliana Alamilla-Beltrán 1, Yair Cruz-Narváez 4 and María L. Zambrano- Zaragoza 2* , Synthesis, Controlled Release, and Stability on Storage of Chitosan-Thyme Essential Oil Nanocapsules for Food Applications Gels 2021, 7, 212. https://doi.org/ 10.3390/gels7040212, 2021
Lorena de Oliveira Felipe , Juliano Lemos Bicas , Meryem Bouhoute , Mitsutoshi Nakajima and Marcos A. Comprehensive study of α-terpineol-loaded oil-in-water (O/W) nanoemulsion: interfacial property, formulation, physical and chemical stability, 2021.
Bantu Karnakar, Swarupa Arvapalli*, Syeda Jabeen, A. Vaishnvi, Ps.Rishika, J.V.C. Sharma, Student, Joginpally B.R.Pharmacy College, Moinabad, Index Copernicus Value 2018: 88.52 Volume 10, Issue 1: January-February : 2021, 68-75
Izham, M. N. M. et al. Preparation and characterization of self nano-emulsifying drug delivery system loaded with citraland its antiproliferative effect on colorectal cells in vitro. Nanomaterials9, (2019).
Rigo, L. et al. Nanoencapsulation of rice bran oil increases its protective effects against UVB radiation-induced skin injury in mice. Eur. J. Pharm. Biopharm.93, (2015).
Hatem Ali1, Abdel Rahman Al-Khalifa, Abdelhakim Aouf, Habiba Boukhebti & Amr Farouk, Effect of nanoencapsulation on volatile constituents, and antioxidant and anticancer activities of Algerian Origanum glandulosum Desf. essential oil, Scientific Reports (2020).
Shubham Tripathi , Umesh kumar Sahu , Jyotsana Meshram1 , Ranjeeta Kumari, D.K Tripathi , Ajazuddin , Amit Alexander , Harish Sharma , Gyanesh Kumar Sahu* ,Formulation and characterization of Virgin Coconut Oil Emulsion (VCOE) for treatment of Alzheimer’s disease , Vol. 10| Issue-02| April- June, 2018
Bilat U., Allemann E., Doelker E. Nanoprecipitation versus emulsion-based techniques for the encapsulation of proteins into biodegradable nanoparticles and process-related stability issues. AAPS Pharm SciTech. 2005; 6(a): 594–604.
Ricardo M. González-Reza, Article Synthesis, Controlled Release, and Stability on Storage of Chitosan-Thyme Essential Oil Nanocapsules for Food Applications, 2021
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
