1,3-Thiazoles: Advances in Synthesis, Properties, and Comprehensive Biological Potential

Authors

  • Vishnu Dev Verma
  • Amrita Singh
  • Himanshi Bhadauria
  • Jay Kumar
  • Jay Kishan Jaiswal
  • Abhishek Kumar Singh
  • Baby Shraddha

Keywords:

Anti-Inflammatory, Antioxidant, Antiviral, Gewald Reaction, Hantzsch Synthesis

Abstract

1,3-Thiazole compounds have garnered considerable interest due to their diverse biological activities and adaptable chemical structures. An extensive summary of 1,3-thiazole derivative synthesis, physicochemical characteristics, and biological uses is given in this review. A wide range of synthetic procedures is covered in depth, including metal-catalyzed and green chemistry techniques, as well as more contemporary approaches, such as the Hantzsch thiazole synthesis. The thiazole moiety is a useful scaffold in drug development because of its strong binding affinity to a variety of biological targets, which is facilitated by its structural flexibility and electrical properties. Additionally, the development of more potent thiazole-based treatments with enhanced selectivity and decreased toxicity has been directed by structure-activity relationship (SAR) research. 1,3-thiazole compounds have been investigated in agrochemicals, dyes, and materials science in addition to pharmacological uses. This review highlights recent advancements in developing thiazole-based heterocyclic compounds, emphasizing their role as a key scaffold in biological and medicinal applications

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2025-07-16

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1.
Dev Verma V, Singh A, Bhadauria H, Kumar J, Jaiswal JK, Kumar Singh A, Shraddha B. 1,3-Thiazoles: Advances in Synthesis, Properties, and Comprehensive Biological Potential. J Neonatal Surg [Internet]. 2025Jul.16 [cited 2025Sep.11];14(32S):5445-69. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/8321

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Vol. 14 No. 32S (2025): Journal of Neonatal Surgery

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