Correlation Of Vitamin D Levels With Inflammatory Cytokines In Autoimmune Disorders
DOI:
https://doi.org/10.63682/jns.v14i32S.9081Keywords:
Vitamin D, cytokines, autoimmune disorders, inflammationAbstract
Background: Vitamin D is a very important immunomodulator and it is also considered to play an important role in control of immune responses. Its low levels in autoimmune diseases are associated with increased inflammation, which is usually further augmented by the increased pro-inflammatory cytokines. The link between vitamin D and the levels of inflammatory cytokines may reveal the way the disease advances and what means may be used to treat the patient.
Objectives: Aim of Study to determine the correlation of vitamin D and inflammatory cytokines in autoimmune patients.
Study design: A cross-sectional study.
Place and duration of study: Department of Physiology, Central Park Medical College, Lahore, Pakistan from March 2024 to October 2024.
Methods: Cross-sectional study was carried out among the patients with autoimmune disorders. The levels of serum vitamin D .and the concentration of cytokines (IL-6, TNF-alpha, IL-10) were determined. The relationship between cytokine levels and vitamin D insufficiency was determined using statistical analysis (selection of vitamin D insufficiency and association of any correlation and t-tests).
Results: They have analyzed a total of 100 patients with a mean of 40.6 years of age (SD = 12.4). Low concentration of vitamin D was associated positively with various pro-inflammatory cytokines such as IL-6, TNF-a, and IL-1-b (p < 0.01). On the contrary, the cytokine levels were lower in patients with high levels of vitamin D. The information indicated that insufficiency of vitamin D increases inflammation in autoimmune diseases.
Conclusion: Human autoimmune disorders are demonstrated to have elevated inflammatory cytokines in the condition of vitamin D deficiency. It is possible that supplementation can control inflammation and control the course of disease but more study needs to be conducted to determine effective doses in terms of clinical practice.
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Argano C, Mirarchi L, Amodeo S, Orlando V, Torres A, Corrao S. The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art. International journal of molecular sciences. 2023;24(20).
Bahmani E, Hoseini R, Amiri E. Home-based aerobic training and vitamin D improve neurotrophins and inflammatory biomarkers in MS patients. Multiple sclerosis and related disorders. 2022;60:103693.
Brusilovsky M, Rochman M, Shoda T, Kotliar M, Caldwell JM, Mack LE, et al. Vitamin D receptor and STAT6 interactome governs oesophageal epithelial barrier responses to IL-13 signalling. Gut. 2023;72(5):834-45.
Daryabor G, Amirghofran Z, Gholijani N, Bemani P. Obesity and Adipose Tissue-derived Cytokines in the Pathogenesis of Multiple Sclerosis. Endocrine, metabolic & immune disorders drug targets. 2022;22(12):1217-31.
Di Marcello F, Di Donato G, d'Angelo DM, Breda L, Chiarelli F. Bone Health in Children with Rheumatic Disorders: Focus on Molecular Mechanisms, Diagnosis, and Management. International journal of molecular sciences. 2022;23(10).
Iamartino L, Brandi ML. The calcium-sensing receptor in inflammation: Recent updates. Frontiers in physiology. 2022;13:1059369.
Johnson WT, McBride D, Kerr M, Nguyen A, Zoccheddu M, Bollmann M, et al. Immunomodulatory Nanoparticles for Modulating Arthritis Flares. ACS nano. 2024;18(3):1892-906.
Kalia V, Studzinski GP, Sarkar S. Role of vitamin D in regulating COVID-19 severity-An immunological perspective. Journal of leukocyte biology. 2021;110(4):809-19.
9. Kondapalli AV, Walker MD. Celiac disease and bone. Archives of endocrinology and metabolism. 2022;66(5):756-64.
Kraus AU, Penna-Martinez M, Shoghi F, Meyer G, Badenhoop K. Monocytic Cytokines in Autoimmune Polyglandular Syndrome Type 2 Are Modulated by Vitamin D and HLA-DQ. Frontiers in immunology. 2020;11:583709.
Li M, Luo L, Lin C, Ni B, Zou L, Song Z, et al. Vitamin D3 mitigates autoimmune inflammation caused by activation of myeloid dendritic cells in SLE. Experimental dermatology. 2024;33(1):e14926.
Long W, Fatehi M, Soni S, Panigrahi R, Philippaert K, Yu Y, et al. Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel. The Journal of physiology. 2020;598(19):4321-38.
Mariz HA, Sato EI, Cardoso PRG, Gonçalves R, Duarte A, de Melo Rego MJB, et al. Vitamin D Presented In Vitro Immunomodulatory Property on T Lymphocyte-Related Cytokines in Systemic Lupus Erythematosus. Inflammation. 2023;46(2):730-8.
Messina OD, Vidal M, Adami G, Vidal LF, Clark P, Torres JAM, et al. Chronic arthritides and bone structure: focus on rheumatoid arthritis-an update. Aging clinical and experimental research. 2023;35(7):1405-16.
1Russo C, Valle MS, Malaguarnera L, Romano IR, Malaguarnera L. Comparison of Vitamin D and Resveratrol Performances in COVID-19. Nutrients. 2023;15(11).
Sadia A, Yasmin T, Imran M, Samra MM, Raza Basra MA. Calcium complexes of oxicams: new dimensions in rheumatoid arthritis treatment. Future medicinal chemistry. 2022;14(23):1771-88.
Sakyi SA, Owusu-Yeboah M, Obirikorang C, Dadzie Ephraim RK, Kwarteng A, Opoku S, et al. Profiling vitamin D, its mediators and proinflammatory cytokines in rheumatoid arthritis: A case-control study. Immunity, inflammation and disease. 2022;10(8):e676.
Soto JR, Anthias C, Madrigal A, Snowden JA. Insights Into the Role of Vitamin D as a Biomarker in Stem Cell Transplantation. Frontiers in immunology. 2020;11:966.
Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H. Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases. Journal of inflammation research. 2022;15:3083-94.
Wang Z, Yi SY, Zhang YY, Wang YD, Chen HL, Guo YJ, et al. The role of vitamin D through SphK1/S1P in the regulation of MS progression. The Journal of steroid biochemistry and molecular biology. 2024;236:106425.
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