The Role of miRNA Let-7a-1 and Let-7f-1 in Regulating Inflammatory and Angiogenic Pathways in Endometriosis
DOI:
https://doi.org/10.52783/jns.v14.1590Keywords:
endometriosis, miRNA let-7a-1, miRNA let-7f-1, biomarkers, molecular therapyAbstract
Background
Endometriosis, a chronic gynecological disorder characterized by the ectopic growth of endometrial tissue, involves complex inflammatory and angiogenic mechanisms. MicroRNAs (miRNAs), particularly Let-7a-1 and Let-7f-1, have been identified as key regulators of these pathways, influencing the progression and symptoms of the disease.
Objectives
This review aims to explore the roles of miRNA Let-7a-1 and Let-7f-1 in the regulation of inflammatory and angiogenic pathways in endometriosis, highlighting their potential as biomarkers and therapeutic targets.
Materials and Methods
A comprehensive literature search was conducted using databases such as PubMed, Scopus, and Web of Science. Relevant studies published between 2000 and 2024 were included, focusing on the expression, function, and regulatory mechanisms of Let-7a-1 and Let-7f-1 in endometriosis. Key findings were synthesized to provide an updated understanding of their biological and clinical relevance.
Results
Evidence indicates that Let-7a-1 and Let-7f-1 play pivotal roles in modulating pro-inflammatory cytokines, angiogenic factors like VEGF, and cellular proliferation in endometriotic lesions. Dysregulated expression of these miRNAs is associated with enhanced inflammatory responses and aberrant angiogenesis, contributing to the persistence and progression of endometriosis. Furthermore, preclinical studies demonstrate that targeting Let-7 family miRNAs can mitigate these processes, suggesting their potential utility in therapeutic strategies.
Conclusion
Let-7a-1 and Let-7f-1 serve as critical modulators in the inflammatory and angiogenic pathways of endometriosis, offering insights into disease pathophysiology. Their roles as biomarkers and therapeutic targets warrant further investigation, paving the way for novel diagnostic and treatment approaches in endometriosis management.
Downloads
Metrics
References
Bendifallah S, Dabi Y, Suisse S, et al. A Bioinformatics Approach to MicroRNA-Sequencing Analysis Based on Human Saliva Samples of Patients with Endometriosis. IJMS. 2022;23(14):8045. doi:10.3390/ijms23148045
Leonova A, Turpin VE, Agarwal SK, Leonardi M, Foster WG. A critical appraisal of the circulating levels of differentially expressed microRNA in endometriosis. Biology of Reproduction. 2021;105(5):1075-1085. doi:10.1093/biolre/ioab134
Febriza A, Hatta M, Natzir R, Kasim VNA, Idrus HH. Activity of Antimicrobial Peptide; Cathelicidin, on Bacterial Infection. TOBIOCJ. 2019;13(1):45-53. doi:10.2174/1874091X01913010045
Antonio LGL, Meola J, Rosa-e-Silva ACJDS, et al. Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis. IJMS. 2023;24(5):4434. doi:10.3390/ijms24054434
Brulport A, Bourdon M, Vaiman D, et al. An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review. Reprod Biol Endocrinol. 2024;22(1):21. doi:10.1186/s12958-023-01181-8
Zubrzycka A, Migdalska-Sęk M, Jędrzejczyk S, Brzeziańska-Lasota E. Assessment of BMP7, SMAD4, and CDH1 Expression Profile and Regulatory miRNA-542-3p in Eutopic and Ectopic Endometrium of Women with Endometriosis. IJMS. 2023;24(7):6637. doi:10.3390/ijms24076637
Anastasiu CV, Moga MA, Elena Neculau A, et al. Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. IJMS. 2020;21(5):1750. doi:10.3390/ijms21051750
Nothnick WB, Al-Hendy A, Lue JR. Circulating Micro-RNAs as Diagnostic Biomarkers for Endometriosis: Privation and Promise. Journal of Minimally Invasive Gynecology. 2015;22(5):719-726. doi:10.1016/j.jmig.2015.02.021
Zubrzycka A, Migdalska-Sęk M, Jędrzejczyk S, Brzeziańska-Lasota E. Circulating miRNAs Related to Epithelial–Mesenchymal Transitions (EMT) as the New Molecular Markers in Endometriosis. CIMB. 2021;43(2):900-916. doi:10.3390/cimb43020064
Wu J, Fang X, Huang H, Huang W, Wang L, Xia X. Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network. Aging. 2021;13(9):12607-12630. doi:10.18632/aging.202937
Febriza A, Natzir R, Hatta M, Alam G, Kasim VN, Idrus HH. Curcumin effects in inducing mRNA gene cathelidicin antimicrobial peptide in Balb/c mice infected with Salmonella typhi.
Tian Z, Chang XH, Zhao Y, Zhu HL. Current biomarkers for the detection of endometriosis. Chinese Medical Journal. 2020;133(19):2346-2352. doi:10.1097/CM9.0000000000001063
Chen G, Guo J, Li W, Zheng R, Shang H, Wang Y. Diagnostic value of the combination of circulating serum miRNAs and CA125 in endometriosis. Medicine. 2023;102(48):e36339. doi:10.1097/MD.0000000000036339
Kasim V, Hatta M, Natzir R, Hadju V, Febriza A, Idrus H. Effects of lime (Citrus aurantifolia) peel to the expression of mRNA toll-like receptors 4 in balb/c mice-infected Salmonella typhi. J Adv Pharm Technol Res. 2020;11(4):169. doi:10.4103/japtr.JAPTR_48_20
Cosar E, Mamillapalli R, Moridi I, Duleba A, Taylor HS. Serum MicroRNA Biomarkers Regulated by Simvastatin in a Primate Model of Endometriosis. Reprod Sci. 2019;26(10):1343-1350. doi:10.1177/1933719118765971
Giudice LC, Oskotsky TT, Falako S, Opoku‐Anane J, Sirota M. Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations. The FASEB Journal. 2023;37(9):e23130. doi:10.1096/fj.202300907
Steinbuch SC, Lüß AM, Eltrop S, Götte M, Kiesel L. Endometriosis-Associated Ovarian Cancer: From Molecular Pathologies to Clinical Relevance. IJMS. 2024;25(8):4306. doi:10.3390/ijms25084306
Wu Y, Yuan W, Ding H, Wu X. Serum exosomal miRNA from endometriosis patients correlates with disease severity. Arch Gynecol Obstet. 2022;305(1):117-127. doi:10.1007/s00404-021-06227-z
Zubrzycka A, Migdalska-Sęk M, Jędrzejczyk S, Brzeziańska-Lasota E. The Expression of TGF-β1, SMAD3, ILK and miRNA-21 in the Ectopic and Eutopic Endometrium of Women with Endometriosis. IJMS. 2023;24(3):2453. doi:10.3390/ijms24032453
Sunarno S, Puspandari N, Fitriana F, Nikmah UA, Idrus HH, Panjaitan NSD. Extended spectrum beta lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae in Indonesia and South East Asian countries: GLASS Data 2018. AIMSMICRO. 2023;9(2):218-227. doi:10.3934/microbiol.2023013
Ochoa Bernal MA, Fazleabas AT. The Known, the Unknown and the Future of the Pathophysiology of Endometriosis. IJMS. 2024;25(11):5815. doi:10.3390/ijms25115815
Brinca AT, Peiró AM, Evangelio PM, et al. Follicular Fluid and Blood Monitorization of Infertility Biomarkers in Women with Endometriosis. IJMS. 2024;25(13):7177. doi:10.3390/ijms25137177
Agrawal S, Tapmeier TT, Rahmioglu N, Kirtley S, Zondervan KT, Becker CM. The miRNA Mirage: How Close Are We to Finding a Non-Invasive Diagnostic Biomarker in Endometriosis? A Systematic Review. IJMS. 2018;19(2):599. doi:10.3390/ijms19020599
Zhang L, Li H, Yuan M, Li D, Sun C, Wang G. Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis. Disease Markers. 2020;2020:1-10. doi:10.1155/2020/2456340
Perricos A, Proestling K, Husslein H, et al. Hsa-mir-135a Shows Potential as A Putative Diagnostic Biomarker in Saliva and Plasma for Endometriosis. Biomolecules. 2022;12(8):1144. doi:10.3390/biom12081144
Nazri HM, Greaves E, Quenby S, Dragovic R, Tapmeier TT, Becker CM. The role of small extracellular vesicle-miRNAs in endometriosis. Human Reproduction. 2023;38(12):2296-2311. doi:10.1093/humrep/dead216
Chico-Sordo L, Ruiz-Martínez T, Toribio M, et al. Identification of miR-30c-5p microRNA in Serum as a Candidate Biomarker to Diagnose Endometriosis. IJMS. 2024;25(3):1853. doi:10.3390/ijms25031853
Kumari P, Sharma I, Saha SC, Srinivasan R, Bhardwaj P. Role of serum microRNAs as biomarkers for endometriosis, endometrioid carcinoma of ovary & endometrioid endometrial cancer. Indian Journal of Medical Research. 2022;156(3):516-523. doi:10.4103/ijmr.IJMR_288_20
Collins KE, Wang X, Klymenko Y, et al. Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis. Front Endocrinol. 2023;14:1162786. doi:10.3389/fendo.2023.1162786
Hosseini M, Hammami B, Kazemi M. Identification of potential diagnostic biomarkers and therapeutic targets for endometriosis based on bioinformatics and machine learning analysis. J Assist Reprod Genet. 2023;40(10):2439-2451. doi:10.1007/s10815-023-02903-y
Marí-Alexandre J, Carcelén AP, Agababyan C, et al. Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis. IJMS. 2019;20(21):5322. doi:10.3390/ijms20215322
Wright KR, Mitchell B, Santanam N. Redox regulation of microRNAs in endometriosis-associated pain. Redox Biology. 2017;12:956-966. doi:10.1016/j.redox.2017.04.037
Ronsini C, Fumiento P, Iavarone I, Greco PF, Cobellis L, De Franciscis P. Liquid Biopsy in Endometriosis: A Systematic Review. IJMS. 2023;24(7):6116. doi:10.3390/ijms24076116
Vanhie A, O D, Peterse D, et al. Plasma miRNAs as biomarkers for endometriosis. Human Reproduction. 2019;34(9):1650-1660. doi:10.1093/humrep/dez116
Li X, Zhang W, Fu J, et al. MicroRNA-451 is downregulated in the follicular fluid of women with endometriosis and influences mouse and human embryonic potential. Reprod Biol Endocrinol. 2019;17(1):96. doi:10.1186/s12958-019-0538-z
Monnaka VU, Hernandes C, Heller D, Podgaec S. Overview of miRNAs for the non-invasive diagnosis of endometriosis: evidence, challenges and strategies. A systematic review. Einstein (São Paulo). 2021;19:eRW5704. doi:10.31744/einstein_journal/2021RW5704
Nothnick WB. MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology. Cells. 2022;11(7):1096. doi:10.3390/cells11071096
Chico-Sordo L, García-Velasco JA. MicroRNAs as Biomarkers and Therapeutic Targets in Female Infertility. IJMS. 2024;25(23):12979. doi:10.3390/ijms252312979
Marí-Alexandre J, Sánchez-Izquierdo D, Gilabert-Estellés J, Barceló-Molina M, Braza-Boïls A, Sandoval J. miRNAs Regulation and Its Role as Biomarkers in Endometriosis. IJMS. 2016;17(1):93. doi:10.3390/ijms17010093
Bjorkman S, Taylor HS. MicroRNAs in endometriosis: biological function and emerging biomarker candidates†. Critchley HO, ed. Biology of Reproduction. 2019;101(6):1167-1178. doi:10.1093/biolre/ioz014
Hon JX, Wahab NA, Karim AKA, Mokhtar NM, Mokhtar MH. MicroRNAs in Endometriosis: Insights into Inflammation and Progesterone Resistance. IJMS. 2023;24(19):15001. doi:10.3390/ijms241915001
Bendifallah S, Dabi Y, Suisse S, et al. MicroRNome analysis generates a blood-based signature for endometriosis. Sci Rep. 2022;12(1):4051. doi:10.1038/s41598-022-07771-7
Szubert M, Nowak-Glück A, Domańska-Senderowska D, et al. miRNA Expression Profiles in Ovarian Endometriosis and Two Types of Ovarian Cancer—Endometriosis-Associated Ovarian Cancer and High-Grade Ovarian Cancer. IJMS. 2023;24(24):17470. doi:10.3390/ijms242417470
Downloads
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.