Anti-Mullerian Hormone (AMH) Levels In Patients Before And After Salpingectomy And Hysterectomy
Keywords:
Hysterectomy, Salpingectomy, Serum AMH Levels, Gynecological SurgeryAbstract
Background: Hysterectomy is the surgical removal of the uterus and, in some circumstances, the ovaries, cervix, fallopian tubes and supporting tissues. Hysterectomy is one of the most performed surgeries in gynecological practice. Hysterectomy is the most common gynecological surgical procedure performed worldwide, with a rate of 2-5 per 1000 women in North America, Europe, Australia, and China. Hysterectomy is used to treat a variety of benign and malignant medical conditions, including fibroids, prolapses, abnormal uterine bleeding, pelvic pain, and cervical, endometrial, and ovarian cancers, pelvic pain associated with endometriosis, pelvic organ prolapse, and adenomyosis.
Objective: Determine serum AMH levels in salpingectomy and hysterectomy patients. Compare serum AMH levels in patients between before and after salpingectomy and hysterectomy. Determine the factors related to changes in serum AMH levels after salpingectomy and hysterectomy.
Methods: The research was conducted at the Educational Network Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University. The research was conducted from April – September 2024. The population of this study is all patients who underwent salpingectomy and hysterectomy at the Education Network Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University.
Results: The subjects of this study were 30-37 years old and had the same proportion related to normal BMI, overweight and obesity. Based on Table 1, it is shown that most of the subjects of this study are more than 9 years of education, not working, primipara, indications of adenomyosis surgery and uterine myoma.
Conclusion: Based on the results of the study and discussion, it can be concluded that serum AMH levels in patients decreased after salpingectomy and hysterectomy. Age and BMI were not associated with changes in serum AMH levels after salpingectomy and hysterectomy. AMH levels can be a biomarker that can help predict the impact of salpingectomy and hysterectomy on women's sexual function after 1 month of undergoing salpingectomy and hysterectomy
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Abdelazim, I.A. et al. (2015) "Ovarian function and ovarian blood supply following premenopausal abdominal hysterectomy," Przeglad Menopauzalny, 14(4), p. 238–242. Available on: https://doi.org/10.5114/pm.2015.56312.
Almog, B. et al. (2011) "Effects of salpingectomy on ovarian response in controlled ovarian hyperstimulation for in vitro fertilization: A reappraisal," Fertility and Sterility, 95(8), p. 2474–2476. Available on: https://doi.org/10.1016/j.fertnstert.2011.03.032.
Amarin, Z.O. (2022) "Hysterectomy: Past, Present and Future," IntechOpen [Preprint]. Available at: doi: 10.5772/intechopen.103086.
Atabekoǧlu, C. et al. (2012) "The effect of total abdominal hysterectomy on serum anti-Müllerian hormone levels: A pilot study," Climacteric, 15(4), p. 393–397. Available on: https://doi.org/10.3109/13697137.2011.642426.
Aydin, K. et al. (2013) "Body composition in lean women with polycystic ovary syndrome: Effect of ethinyl estradiol and drospirenone combination," Contraception, 87(3), p. 358–362. Available on: https://doi.org/10.1016/j.contraception.2012.07.005.
Barbotin, A.L. et al. (2019) "Emerging Roles of Anti-Müllerian Hormone in Hypothalamic-Pituitary Function," Neuroendocrinology, 109(3), pp. 218–229. Available on: https://doi.org/10.1159/000500689.
Begum, M.R. et al. (2021) "Association of Emergency Salpingectomy with Ovarian Reserve," Bangladesh Journal of Fertility & Sterility, 1(2), pp. 88–92.
Bischiniotis, S., Mikos, T. and Grimbizis, G.F. (2024) "Surgical Treatment of Adenomyosis," Current Obstetrics and Gynecology Reports, 13(2), pp. 80–87. Available on: https://doi.org/10.1007/s13669-024-00383-0.
Carugno, J. and Fatehi., M. (2023) "Abdominal Hysterectomy," StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing [Preprint].
Hello, X. et al. (2019) "Effects of hysterectomy with simultaneous bilateral salpingectomy on the subsequent pelvic mass," Journal of Ovarian Research, 12(1), pp. 1–8. Available on: https://doi.org/10.1186/s13048-019-0504-6.
Chen, T. et al. (2020) "Salpingectomy may decrease antral follicle count but not live birth rate for IVF-ET patients aged 35-39 years: A retrospective study," Journal of Ovarian Research, 13(1), p. 1–8. Available on: https://doi.org/10.1186/s13048-020-00678-9.
Chen, Y. et al. (2014) "The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: A prospective cohort study," Journal of Ovarian Research, 7(1), p. 1–8. Available on: https://doi.org/10.1186/s13048-014-0108-0.
Cheng, X. et al. (2016) "Comparison of the fertility outcome of salpingotomy and salpingectomy in women with tubal pregnancy: A systematic review and meta-analysis," PLoS ONE, 11(3), p. 1–16. Available on: https://doi.org/10.1371/journal.pone.0152343.
Cho, H. yon et al. (2017) "Assessment of ovarian reserve after hysterectomy: Laparoscopic vs. non-laparoscopic surgery," European Journal of Obstetrics and Gynecology and Reproductive Biology, 210, p. 54–57. Available on: https://doi.org/10.1016/j.ejogrb.2016.12.003.
Chohan, L. and Richardson, D.L. (2019) "ACOG COMMITTEE OPINION Number 774 Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention," Obstetrics and Gynecology, 133(4), p. E279–E284. Available on: https://doi.org/10.1097/AOG.0000000000003164.
Chun, S. and Ji, Y. Il (2020a) "Effect of Hysterectomy on Ovarian Reserve in the Early Postoperative Period Based on the Type of Surgery," Journal of Menopausal Medicine, 26(3), p. 159. Available on: https://doi.org/10.6118/jmm.20010.
Chun, S. and Ji, Y. Il (2020b) "Effect of Hysterectomy on Ovarian Reserve in the Early Postoperative Period Based on the Type of Surgery," Journal of Menopausal Medicine, 26(3), p. 159. Available on: https://doi.org/10.6118/jmm.20010.
Dewailly, D. et al. (2014) "The physiology and clinical utility of anti-Müllerian hormone in women," Human Reproduction Update, 20(3), pp. 370–385. Available on: https://doi.org/10.1093/humupd/dmt062.
Dumont, A. et al. (2015) "Role of Anti-Müllerian Hormone in pathophysiology, diagnosis and treatment of Polycystic Ovary Syndrome: A review," Reproductive Biology and Endocrinology, 13(1), p. 8–10. Available on: https://doi.org/10.1186/s12958-015-0134-9.
Findley, A.D. et al. (2013) "Short-Term Effects of Salpingectomy during Laparoscopic Hysterectomy on Ovarian Reserve: A Randomized Controlled Trial," Journal of Minimally Invasive Gynecology, 20(6), p. S42. Available on: https://doi.org/10.1016/j.jmig.2013.08.132.
Galanderov, R. et al. (2015) "Evaluation of the effects of hysterectomy on ovarian reserve by antimullerian hormone and ultrasonography," J Ist Faculty Med, 78(3), pp. 67–71.
Gluck, O. et al. (2018) "The impact of salpingectomy on anti-mullerian hormone levels and ovarian response of in vitro fertilization patients," Israel Medical Association Journal, 20(8), pp. 509–512.
Gurbuz, T. et al. (2020) "Correlation between Anti-Mullerian Hormone Levels and Sexual Dysfunction in Infertile Women," Asian Research Journal of Gynaecology and Obstetrics, 4(2), pp. 10–16. Available on: https://www.researchgate.net/profile/Tugba-Guerbuez-2/publication/343587338_Correlation_between_Anti-Mullerian_Hormone_Levels_and_Sexual_Dysfunction_in_Infertile_Women/links/5f32d5d3299bf13404bab219/Correlation-between-Anti-Mullerian-Hormone-Levels-and-Se.
Herawati, S. (2019) "Anti-Mullerian Hormone (AMH) as a Novel Marker for Ovarian Function: A Review," Bali Medical Journal, 8(2), p. 475–481. Available on: https://doi.org/10.15562/bmj.v8i2.1372.
Ho, C.Y. et al. (2022) "Prior salpingectomy impairs the retrieved oocyte number in vitro fertilization cycles of women under 35 years old without optimal ovarian reserve," PLoS ONE, 17(5 May), pp. 1–12. Available on: https://doi.org/10.1371/journal.pone.0268021.
Hosseinzadeh, F. et al. (2022) "The Effect of Age and AMH Level on ART Outcomes in Patients With Reduced Ovarian Reserve: A Retrospective Cross-sectional Study," Journal of Obstetrics and Gynecology of India, 72(5), p. 420–425. Available on: https://doi.org/10.1007/s13224-021-01582-y.
Huang, Y. et al. (2023) "Effect of hysterectomy on ovarian function: a systematic review and meta-analysis," Journal of Ovarian Research, 16(1), p. 1–9. Available on: https://doi.org/10.1186/s13048-023-01117-1.
Iwase, A. et al. (2014) "Assessment of ovarian reserve using anti-Müllerian hormone levels in benign gynecologic conditions and surgical interventions: A systematic narrative review," Reproductive Biology and Endocrinology, 12(1), p. 1–8. Available on: https://doi.org/10.1186/1477-7827-12-125.
Jamil, Z. et al. (2016) "Anti-Mullerian Hormone: Above and beyond Conventional Ovarian Reserve Markers," Disease Markers, 2016. Available on: https://doi.org/10.1155/2016/5246217.
Jones, R. and Lopez, K.H. (2013) "Human Reproductive Biology," in Human Reproductive Biology fourth edition. Elsevier, p. 2013–2015. Available on: https://doi.org/10.1016/B978-0-12-382184-3.00013-1.
Jurkovic, D. and Rajah, K. (2019) Early Pregnancy Failure. Third Edit, Fetal Medicine: Basic Science and Clinical Practice. Third Edit. Elsevier Ltd. Available on: https://doi.org/10.1016/B978-0-7020-6956-7.00005-1.
Kiremitli, S. et al. (2022) "The effect of hysterectomy types on vaginal length, vaginal shortening rate and FSFI scores," Taiwanese Journal of Obstetrics and Gynecology, 61(3), pp. 427–432. Available on: https://doi.org/10.1016/j.tjog.2022.02.042.
Kotlyar, A. et al. (2017) "The Effect of Salpingectomy on Ovarian Function," Journal of Minimally Invasive Gynecology, 24(4), pp. 563–578. Available on: https://doi.org/10.1016/j.jmig.2017.02.014.
Kotlyar, A.M. and Seifer, D.B. (2021) "Ethnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review," Frontiers in Endocrinology, 11(February), pp. 1–6. Available on: https://doi.org/10.3389/fendo.2020.593216.
Kozlowski, I.F. et al. (2022) "Correlation between anti-Müllerian hormone, age, and number of oocytes: A retrospective study in a Brazilian in vitro fertilization center," Jornal Brasileiro de Reproducao Assistida, 26(2), p. 214–221. Available on: https://doi.org/10.5935/1518-0557.20210083.
van Lieshout, L.A.M. et al. (2019) "Hysterectomy with opportunistic salpingectomy versus hysterectomy alone," Cochrane Database of Systematic Reviews, 2019(8). Available on: https://doi.org/10.1002/14651858.CD012858.pub2.
Lim, S. et al. (2021) "Correlations among anti-Müllerian hormone levels, body mass index and lipid profile in reproductive-aged women: The Korea Nurses' Health Study," Nursing Open, 8(6), p. 2996–3005. Available on: https://doi.org/10.1002/nop2.1011.
Lin, C. et al. (2021) "The Value of Anti-Müllerian Hormone in the Prediction of Spontaneous Pregnancy: A Systematic Review and Meta-Analysis," Frontiers in Endocrinology, 12(October), p. 1–12. Available on: https://doi.org/10.3389/fendo.2021.695157.
Louis, L. and Shafi, M. (2016) "Salpingectomy," Obstetrics, Gynaecology and Reproductive Medicine, 26(4), pp. 120–122. Available on: https://doi.org/10.1016/j.ogrm.2016.01.002.
Lowder, J.L. and Oliphant, S. (2012) Gynecologic conditions and body image: A lifetime perspective, Encyclopedia of Body Image and Human Appearance. Elsevier Inc. Available at: https://doi.org/10.1016/B978-0-12-384925-0.00074-2.
Luo, J. et al. (2019) "The effect of salpingectomy on the ovarian reserve and ovarian response in ectopic pregnancy: A systematic review and meta-analysis," Medicine (United States), 98(47). Available on: https://doi.org/10.1097/MD.0000000000017901.
Marino, S., Canela, C.D. and Nama, N. (2023) "Tubal Sterilization," StatPearls Publishing [Preprint].
Meena, D. et al. (2014) "Anti-mullerian hormone: A new marker of ovarian function," Journal of Obstetrics and Gynecology of India, 64(2), p. 130–133. Available on: https://doi.org/10.1007/s13224-013-0482-3.
Mills, K. et al. (2021) "Salpingectomy vs tubal ligation for sterilization: a systematic review and meta-analysis," American Journal of Obstetrics and Gynecology, 224(3), p. 258-265.e4. Available on: https://doi.org/10.1016/j.ajog.2020.09.011.
Mizusawa, Y. et al. (2020) "A retrospective analysis of ovarian response to gonadotropins after laparoscopic unilateral or bilateral salpingectomy for hydrosalpinges," Health Science Reports, 3(3), pp. 1–5. Available on: https://doi.org/10.1002/hsr2.187.
Moolhuijsen, L.M.E. and Visser, J.A. (2020) "Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function," Journal of Clinical Endocrinology and Metabolism, 105(11), p. 3361–3373. Available on: https://doi.org/10.1210/clinem/dgaa513.
Moorman, P.G. et al. (2011) "Effect of hysterectomy with ovarian preservation on ovarian function," Obstetrics and Gynecology, 118(6), pp. 1271–1279. Available on: https://doi.org/10.1097/AOG.0b013e318236fd12.
Moy, V. et al. (2015) "Obesity adversely affects serum anti-müllerian hormone (AMH) levels in Caucasian women," Journal of Assisted Reproduction and Genetics, 32(9), pp. 1305–1311. Available on: https://doi.org/10.1007/s10815-015-0538-7.
Pereira, J.M.A. et al. (2022) "Applicability, Safety, and Efficiency of Salpingectomy versus Electrocoagulation and Laparoscopic Tubal Section in Ambulatory | Aplicabilidade, segurança e eficiência da salpingectomia versus eletrocoagulação e secção tubar laparoscópica em regime de ambu," Revista Brasileira de Ginecologia e Obstetricia, 44(9), pp. 866–870.
Pillarisetty, L. and Mahdy, H. (2021) Vaginal Hysterectomy. Treasure Island (FL): StatPearls Publishing.
Pillarisetty, L.S. and Mahdy, H. (2023) "Vaginal hysterectomy," StatPearls Publishing [Preprint].
Plessis, M. du (2010) "Anti-Müllerian hormone (AMH): Physiology and clinical utility," Pathologist Patoloe, 28(33), p. 2–3.
Proshchenko, O. and Ventskivska, I. (2022) "Hysterectomy with opportunistic salpingectomy and its influence on structural-functional parameters of ovarian tissue," ScienceRise: Medical Science, 2(2(47)), pp. 17–22. Available on: https://doi.org/10.15587/2519-4798.2022.256406.
Qin, F., Du, D.F. and Li, X.L. (2016) "The Effect of Salpingectomy on Ovarian Reserve and Ovarian Function," Obstetrical and Gynecological Survey, 71(6), pp. 369–376. Available on: https://doi.org/10.1097/OGX.0000000000000323.
Silpaibulpanich, N. and Maneerat, P. (2023) "Changes of Ovarian Reserve After Hysterectomy for Non-Oncologic Conditions in Reproductive-Aged Women: A Prospective Study," Thai J Obstet Gynaecol, 28.
Singh, Nisha et al. (2023) "Impact of ovarian diseases on fertility reserve as assessed through serum AMH levels in reproductive age women," Journal of Endometriosis and Uterine Disorders, 4(November), p. 100051. Available on: https://doi.org/10.1016/j.jeud.2023.100051.
Song, T. et al. (2017) "Impact of opportunistic salpingectomy on anti-Müllerian hormone in patients undergoing laparoscopic hysterectomy: a multicentre randomised controlled trial," BJOG: An International Journal of Obstetrics and Gynaecology, 124(2), p. 314–320. Available on: https://doi.org/10.1111/1471-0528.14182.
Tavana, Z. et al. (2021) "Does laparoscopic hysterectomy + bilateral salpingectomy decrease the ovarian reserve more than total abdominal hysterectomy? A cohort study, measuring anti-Müllerian hormone before and after surgery," BMC Women's Health, 21(1), pp. 1–7. Available on: https://doi.org/10.1186/s12905-021-01472-5.
Tehranian, A. et al. (2017) "Effects of salpingectomy during abdominal hysterectomy on ovarian reserve: a randomized controlled trial," Gynecological Surgery, 14(1), p. 1–6. Available on: https://doi.org/10.1186/s10397-017-1019-z.
Vahedpour, Z. et al. (2019) "The effects of salpingectomy on the serum level of anti-M ̈ullerian hormone: a single-blind randomized controlled trial," Journal of Gynecology Obstetrics and Human Reproduction [Preprint].
Wang, H.Y. et al. (2013) "Comparison of serum anti-Mullerian hormone levels following hysterectomy and myomectomy for benign gynaecological conditions," European Journal of Obstetrics and Gynecology and Reproductive Biology, 171(2), pp. 368–371. Available on: https://doi.org/10.1016/j.ejogrb.2013.09.043.
Wang, Y. and Ying, X. (2020) "Sexual function after total laparoscopic hysterectomy or transabdominal hysterectomy for benign uterine disorders: A retrospective cohort," Brazilian Journal of Medical and Biological Research, 53(3), p. 1–7. Available on: https://doi.org/10.1590/1414-431x20199058.
Yuan, Z. et al. (2019) "The effects of hysterectomy with bilateral salpingectomy on ovarian reserve," International Journal of Gynecology and Obstetrics, 145(2), pp. 233–238. Available on: https://doi.org/10.1002/ijgo.12798.
Zeng, X. et al. (2022) "Anti-Müllerian hormone was independently associated with central obesity but not with general obesity in women with PCOS," Endocrine Connections, 11(1). Available on: https://doi.org/10.1530/EC-21-0243.
Zuitasari, A. et al. (2022) "Influence Total Hysterectomy against Function Sexual," Indones J Obstet Gynecol, pp. 18–24.
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