Bacterial Profile and Antibiotic Sensitivity in Pregnant Women with Premature Rupture of Membranes
Keywords:
Premature Rupture of Membranes, Bacterial Profile, Antibiotic Sensitivity, Pregnant Women, Urinary Tract InfectionAbstract
Background: Premature Rupture of Membranes (PROM) is a significant obstetric complication that increases the risk of maternal and neonatal infections. Identifying the bacterial profile and their antibiotic sensitivity is crucial for effective management and treatment.
Objective: This study aims to determine the bacterial profile and antibiotic sensitivity patterns in pregnant women with PROM.
Methods: This analytical observational study used a prospective cross-sectional design. Urine samples were collected from pregnant women diagnosed with PROM at the Educational Network Hospital, Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, from January to June 2024. Bacterial identification and antibiotic susceptibility testing were performed using standard microbiological techniques. Data were analyzed using univariate and bivariate methods, with SPSS ver. 25.
Results: The most commonly isolated bacterium was Escherichia coli, followed by Enterobacter cloacae ssp. cloacae, Enterococcus faecalis, Staphylococcus haemolyticus, Aeromonas hydrophila/caviae, Enterococcus faecium, Pseudomonas aeruginosa, and Streptococcus agalactiae. Antibiotic sensitivity analysis revealed that Ciprofloxacin and Tigecycline had the highest effectiveness against the identified bacteria, with E. coli showing significant sensitivity to Cefazolin. The highest antibiotic resistance was observed in the cephalosporin group.
Conclusion: The bacterial profile in urine samples can serve as a marker for PROM risk and aid in the selection of appropriate antibiotic therapy. The use of Ciprofloxacin, Tigecycline, and Cefazolin is recommended for managing bacterial infections in PROM cases. Early detection and targeted antibiotic therapy may help prevent complications and improve maternal and neonatal outcomes.
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