The Effect of PRF Membrane Administration on TGF-β and IL-6 Expression in the Superior Rectus Muscle Post-Strabismus Surgery (An Experimental Study on New Zealand Rabbits): A Literature Review
DOI:
https://doi.org/10.52783/jns.v14.1852Keywords:
Ocular Misalignment, Strabismus Surgery, Fibrosis, Wound Healing, Platelet-Rich Fibrin (PRF), Transforming Growth Factor-beta (TGF-β), Interleukin-6 (IL-6)Abstract
Strabismus surgery is a common treatment for correcting ocular misalignment. However, postoperative complications, such as fibrosis, often arise and affect recovery and surgical outcomes. Fibrosis is influenced by inflammatory mediators, including Transforming Growth Factor-beta (TGF-β) and Interleukin-6 (IL-6). Platelet-Rich Fibrin (PRF), a platelet concentrate known for its regenerative properties, has been studied for its potential to modulate these inflammatory pathways. This review explores the effect of PRF membranes on TGF-β and IL-6 expression in the superior rectus muscle following strabismus surgery. Findings from experimental studies on New Zealand white rabbits suggest that PRF application can reduce these cytokines' levels, thereby limiting fibrosis and promoting better wound healing. PRF's ability to release growth factors may improve surgical outcomes by supporting tissue repair and reducing inflammation. Although promising evidence from animal studies exists, further clinical research is needed to evaluate PRF's effectiveness and safety in human applications. This review highlights the potential of incorporating PRF into surgical protocols to enhance recovery and minimize complications in strabismus surgery.
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