Formulation and Evaluation of Solid Lipid Nanoparticle (SLN) of Andrographolide by Solvent Evaporation Method
DOI:
https://doi.org/10.52783/jns.v14.2713Keywords:
Solid lipid nanoparticles, Andrographolide, Solvent evaporation method, Lecithin, Phosphatidylcholine, Almond oilAbstract
Andrographolide is a potential therapeutic agent that suffers from poor aqueous solubility. Nanoparticles are frequently employed to control the delivery of drugs and various growth factors to tissues/cells. Nanocarriers, in diverse formulations, have the potential to transport both synthetic and natural anticancer therapeutic drugs Therapy applications of AG are, however, seriously constrained because of poor bioavailability, short plasma half-life, and inappropriate tissue localization. Nanoparticulation of AG was therefore envisaged as a possible solution for management of liver dysfunction. Modified solvent evaporation method can be utilized for the development of lecithin nanoparticles. Polymer and crosslinking agent concentrations and sonication time are rate-limiting factors for the development of the optimized formulation. It is thus concluded that by adopting a systematic formulation approach, an optimum point can be reached in the shortest time with minimum efforts to achieve desirable rheological and in vitro release property for in situ forming system.
Downloads
Metrics
References
Sharma R, Yasir M, Bhaskar S. Formulation and evaluation of paclitaxel loaded PSA-PEG nanoparticles. J Appl Pharm Sci 2011; 01:96-8.
Jia L, Zhang D. Nanostructured Lipid Carrier for Parenteral Delivery of Silybin: Biodistribution and Pharmacokinetic Studies. Colloids and surface B: Bio interfaces. 2010; 80: 213-218.
Savjani KT, Gajjar AK, Savjani JK. Drug solubility: importance and enhancement techniques. ISRN Pharm 2012; 2012:195727.
Takemoto JK, Reynolds JK, Remsberg CM, Vega-Villa KR, Davies NM: Clinical Pharmacokinetic and Pharmacodynamic Profile of Etoricoxib. Clin Pharmacokinetic. 2008; 47(11): 703-20.
Mohante S, Boga PK. Role of nanoparticles in drug delivery system. Int J Res Pharm Biomed Sci 2010; 1:41-66.
Soppimath KS, Aminabhavi TM, Kulkarni, AR, Rudzinski WE. Biodegradable Polymeric nanoparticles as drug delivery devices. J Control Release 2001:1-20.
Patel Dilip, Dasgupta Sandipan, Dey Sanjay, Roja Ramani Y, Ray Subhabrata, Mazumder Bhaskar. Nanostructured Lipid Carriers (NLC)-Based Gel for the Topical Delivery of Aceclofenac: Preparation, Characterization, And In Vivo Evaluation. Sci Pharm. 2012, 80: 749–764.
Edwards DA, Langer R. A Linear Theory of Transdermal Transport Phenomena. J.Pharm. Sci. 1994; 83: 1315-1334.
Shendge RS, Sayyad FJ. Formulation development and evaluation of colonic drug delivery system of budesonide microspheres by using spray drying technique. J Pharm Res 2013;6:456-61.
Bathool A, Vishakante GD, Khan MS, Shivakumar HG. Development and characterization of atorvastatin calcium loaded chitosan nanoparticles for sustain drug delivery. Adv Mater Lett2012; 3:466-70.
Nesalin JA, Smith AA. Preparation and evaluation of chitosan nanoparticles containing zidovudine. Asian J Pharm Sci 2012; 7:80-4.
Singh A, Nainwal P, Nanda D, Jain DA. Solubility enhancement study of pioglitazone using solid dispersion as solubilization technique. IJSID 2011; 1:95-100.
Mukherjee S, Ray S, Thakur R.S. Solid Lipid Nanoparticles (SLN): A Modern Formulation Approach in Drug Delivery System. Indian Journal of Pharmaceutical Sciences. 2009; 71(4): 349-358.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material for any purpose, even commercially.
Terms:
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
