Formulation and Evaluation of Haloperidol Decanoate Containing Transdermal Patch for the Treatment of Psychosis
Keywords:
Transdermal drug delivery system, Patch, Film, haloperidol decanoate, Natural polymerAbstract
Transdermal patches are a non-invasive method of drug administration. It is an adhesive patch designed to deliver a specific dose of medication through the skin and into the bloodstream throughout the body. Transdermal drug delivery has several advantages over other routes of administration, for instance, it is less invasive, patient-friendly, and has the ability to bypass first-pass metabolism and the destructive acidic environment of the stomach that occurs upon the oral ingestion of drugs. For decades, transdermal patches have attracted attention and were used to deliver drugs such as nicotine, fentanyl, nitroglycerin, and clonidine to treat various diseases or conditions. Recently, this method is also being explored as a means of delivering biologics in various applications. The most common routes of drug delivery are the oral and parenteral routes with the majority of small molecule drugs conventionally delivered orally. The oral route has the advantage of pre-determined doses, portability and patient self-administration. For these reasons, the oral route remains the most convenient means of delivering medications
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