Formulation And Evaluation of Morinda Citrifolia Plant Extract Containing Phytosomes
DOI:
https://doi.org/10.63682/jns.v14i2S.7103Keywords:
Rheumatoid arthrhitis, inflammatory disorder, phytosomes, morinda citrifolia, herbal treatmentAbstract
Rheumatoid Arthritis (RA) is a substantial worldwide health challenge, prompting the investigation of alternative medicines to enhance traditional therapy. This systematic study assesses the efficacy of herbal remedies in the treatment of rheumatoid arthritis (RA). Natural plant extracts and phytoconstituents have significant in vitro bioactivity; however, their in vivo bioactivity is diminished due to inadequate lipid solubility, the presence of large multi-ring compounds, or gastrointestinal degradation. Polyphenolic phytoconstituents were complexed with phospholipids, primarily phosphatidylcholine, which facilitates molecular attachment of components to create innovative drug delivery systems such as phytosomes. The essential components of the herbal extract are formulated to safeguard against disruption by stomach acids and gut bacteria, since phytosomes possess the capability to traverse lipid-rich biomembranes and enhance bioavailability. The primary aim of this work is to construct a phytosome combination derived from Morinda citrifolia to improve bioavailability relative to conventional pharmaceuticals. The research also seeks to investigate the characteristics of phytosomes for the prospective creation of a herbal gel system for rheumatoid arthritis therapy.
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