Microwave Assisted Organic Synthesis, Characterization And Evalaution Of Antimicrobial Potential Of Benzimidazole-Cobalt Complex Analogues
Keywords:
Benzimidazole, Cobalt complex, antimicrobial, Synthesis, Microwave assiated organic synthesisAbstract
The synthesis of Schiff base derivatives of 2-Amino benzimidazole and their cobalt complex with microwave assistance and their antibacterial activity screening are the topics of this paper. The antibacterial and antifungal properties of the synthesized ligand and its cobalt complex were evaluated. Interest in Schiff base metal complexes is growing. There are several uses for these complexes, including the treatment of cancer, as fungicides, antiviruses, antibactericides, and for other biological purposes. Benzimidazoles are particularly helpful subunits or intermediates for the creation of compounds of biological or pharmacological value. The Schiff base of Co(II) complexes used in this investigation were created using the Schiff base ligand. Additionally, 2-aminobenzimidazole and 9-anthracene carboxaldehyde react under microwave radiation to produce the Schiff base ligand1-(anthracen-9-yl)-N-(1H-benzimidazol-2-yl)methanimine. Recrystallization was used to purify the produced chemicals, and Additionally, substances tested for antibiotic activity against Candida albicans (ATCC 10231), Streptococcus pneumoniae (ATCC 49619), Klebsiella pneumoniae (NCIM 5432), Pseudomonas aeruginosa (NCIM 2257), Staphylococcus aureus (NCIM 2079), and Escherichia coli (NCIM 2256).
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