Hierarchical Multiclass Classification Of Non-Small Cell Lung Cancer Leveraging Efficientnet-B3 For Enhanced Diagostic Precision

Authors

  • Swathi Bonthala
  • Suhasini. A
  • Suvarchala. K

Keywords:

NSCLC classification, Detection, EfficientNet-B3, Transfer Learning, ImageNet

Abstract

Among all forms of cancer, lung cancer has the highest global prevalence and continues to be the leading cause of cancer-related mortality. Lung cancer is categorized into two distinct forms: non-small cell lung cancer (NSCLC), which constitutes approximately 85% of cases, and small cell lung cancer (SCLC), a less common but more aggressive subtype. The primary subtypes of NSCLC include large cell carcinoma, squamous carcinoma, and adenocarcinoma which differ in histopathological features, molecular markers, and treatment responses. CT scan imaging plays a crucial role in accurately diagnosing lung cancer, facilitating the generation of high-quality diagnostic images for further analysis. Deep learning-based convolutional neural networks (CNNs) have proven highly effective in detecting and classifying lung cancer, leveraging hierarchical feature extraction from CT scan images. While CNNs demonstrate strong performance in lung cancer detection, they suffer from high computational costs and prolonged training times. Transfer learning addresses these limitations by leveraging pre-trained models, making it particularly effective for medical imaging with scare-labelled data. In this paper, we investigate the use of EfficientNet-B3 to enhance the accuracy of lung cancer detection. The model’s performance is evaluated using various metrics, including accuracy, precision, recall, F1-score, and ROC curve. Comparative analysis shows that ResNet achieves 91% accuracy, while VGG-16 attains 94%. Further improvements are observed with EfficientNet-B3, which achieves an accuracy of 98% making it the most accurate model among the assessed

Downloads

Download data is not yet available.

References

X Zhan, H Long, F Gou, X Duan, G Kong, A convolutional neural network-based intelligent medical system with sensors for assistive diagnosis and decision-making in non-small cell lung cancer. Sensors 2021, 21(23), 7996; https://doi.org/10.3390/s21237996.

Xueyun Tan, Feng Pan, Na Zhan, Sufei Wang, Zegang Dong, Yan Li, Guanghai Yang, Bo Huang,Yanran Multimodal integration to identify the invasion status of lung adenocarcinoma intraoperatively. https://doi.org/10.1016/j.isci.2024.111421

Yu, L.; Tao, G.; Zhu, L.; Wang, G.; Li, Z.; Ye, J.; Chen, Q. Prediction of pathologic stage in non-small cell lung cancer using machine learning algorithm based on CT image feature analysis. BMC Cancer 2019, 19, 464; https;//doi.org/10.1186/s12885-019-5646-9

Huan Yang1, Lili Chen2, Zhiqiang Cheng3, Minglei Yang4, Jianbo Wang5, Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study. http:// doi.org/10.1186/s12916-021-01953-2.

Masud, M.; Sikder, N.; AlNahid, A.; Bairagi, A.K.; Alzain, M.A. A machine learning approach to diagnosing lung and colon cancer using a deep learning-based classification framework. Sensors 2021, 21, 748.

Wu, J.; Chen, Z.; Zhao, M. An efficient data packet iteration and transmission algorithm in opportunistic social networks. J. Ambient. Intell. Humaniz. Comput. 2020, 11, 3141–3153.

Bębas, E.; Borowska, M.; Derlatka, M.; Oczeretko, E.; Hładuński, M.; Szumowski, P.; Mojsak, M. Machine-learning-based classification of the histological subtype of non-small-cell lung cancer using MRI texture analysis. Biomed. Signal Process. Control 2021, 66, 102446.

Guo, J.; Wang, C.; Xu, X.; Shao, J.; Yang, L.; Gan, Y.; Yi, Z.; Li, W. DeepLN: An artificial intelligence-based automated system for lung cancer screening. Ann. Transl. Med. 2020, 8, 1126

Ahmad, A.S.; Mayya, A.M. A new tool to predict lung cancer based on risk factors. Heliyon 2020, 6, e03402

Cui, L.; Li, H.; Hui, W.; Chen, S.; Yang, L.; Kang, Y.; Bo, Q.; Feng, J. A deep learning-based framework for lung cancer survival analysis with biomarker interpretation. BMC Bioinform. 2020, 21, 112.

Zhang, Y.H.; Lu, Y.; Lu, H.; Zhou, Y.M. Development of a Survival Prognostic Model for Non-small Cell Lung Cancer. Front. Oncol. 2020, 10, 362.

Wang, J.; Chen, N.; Guo, J.; Xu, X.; Liu, L.; Yi, Z. SurvNet: A Novel Deep Neural Network for Lung Cancer Survival Analysis with Missing Values. Front. Oncol. 2021, 10, 588990.

Huang, Z.; Hu, C.; Chi, C.; Jiang, Z.; Tong, Y.; Zhao, C. An Artificial Intelligence Model for Predicting 1- Year Survival of Bone Metastases in Non-Small-Cell Lung Cancer Patients Based on XGBoost Algorithm. BioMed Res. Int. 2020, 2020, 3462363.

Lu, C.; Bera, K.; Wang, X.; Prasanna, P.; Xu, J.; Janowczyk, A.; Beig, N.; Yang, M.; Fu, P.; Lewis, J.; et al. A prognostic model for overall survival of patients with early-stage non-small cell lung cancer: A multicentre, retrospective study. Lancet Digit. Health 2020, 2, e594–e606.

Lai, Y.H.; Chen, W.N.; Hsu, T.C.; Lin, C.; Tsao, Y.; Wu, S. Overall survival prediction of non-small cell lung cancer by integrating microarray and clinical data with deep learning. Sci. Rep. 2020, 10, 4679.

She, Y.; Jin, Z.; Wu, J.; Deng, J.; Zhang, L.; Su, H.; Jiang, G.; Liu, H.; Xie, D.; Cao, N.; et al. Development and Validation of a Deep Learning Model for Non-Small Cell Lung Cancer Survival. JAMA Netw. Open 2020, 3, e205842.

Cui, R.; Chen, Z.; Wu, J.; Tan, Y.L.; Yu, G.H. A Multiprocessing Scheme for PET Image Pre-Screening, Noise Reduction, Segmentation and Lesion Partitioning. IEEE J. Biomed. Heal. Inform. 2021, 25, 1699–1711.

Baek, S.; He, Y.; Allen, B.G.; Buatti, J.M.; Smith, B.J.; Tong, L.; Sun, Z.; Wu, J.; Diehn, M.; Loo, B.W.; et al. Deep segmentation networks predict survival of non-small cell lung cancer. Sci. Rep. 2019, 9, 17286.

Lee, B.; Chun, S.H.; Hong, J.H.; Woo, I.S.; Kim, S.; Jeong, J.W.; Kim, J.J.; Lee, H.W.; Na, S.J.; Beck, K.S.; et al. DeepBTS: Prediction of Recurrence-free Survival of Non-small Cell Lung Cancer Using a Time-binned Deep Neural Network. Sci. Rep. 2020, 10, 1952

Luo, S.; Xu, J.; Jiang, Z.; Liu, L.; Wu, Q.; Leung, E.L.H.; Leung, A.P. Artificial intelligence-based collaborative filtering method with ensemble learning for personalized lung cancer medicine without genetic sequencing. Pharmacol. Res. 2020, 160, 105037.

Wu, J.; Zhuang, Q.; Tan, Y. Auxiliary Medical Decision System for Prostate Cancer Based on Ensemble Method. Comput. Math. Methods Med. 2020, 2020, 6509596.

Cui, R.; Chen, Z.; Wu, J.; Tan, Y.L.; Yu, G.H. A Multiprocessing Scheme for PET Image Pre-Screening, Noise Reduction, Segmentation and Lesion Partitioning. IEEE J. Biomed. Heal. Inform. 2021, 25, 1699–1711.

Lee, B.; Chun, S.H.; Hong, J.H.; Woo, I.S.; Kim, S.; Jeong, J.W.; Kim, J.J.; Lee, H.W.; Na, S.J.; Beck, K.S.; et al. DeepBTS: Prediction of Recurrence-free Survival of Non-small Cell Lung Cancer Using a Time-binned Deep Neural Network. Sci. Rep. 2020, 10, 1952.

Luo, S.; Xu, J.; Jiang, Z.; Liu, L.; Wu, Q.; Leung, E.L.H.; Leung, A.P. Artificial intelligence-based collaborative filtering method with ensemble learning for personalized lung cancer medicine without genetic sequencing. Pharmacol. Res. 2020, 160, 105037.

Wu, J.; Zhuang, Q.; Tan, Y. Auxiliary Medical Decision System for Prostate Cancer Based on Ensemble Method. Comput. Math. Methods Med. 2020, 2020, 6509596.

Lin, Chun-Hui, Cheng-Jian Lin, Yu-Chi Li, and Shyh-Hau Wang. "Using generative adversarial networks and parameter optimization of convolutional neural networks for lung tumor classification." Applied Sciences 11, no. 2 (2021): 480.

Meldo, A.; Utkin, L.; Kovalev, M.; Kasimov, E. The natural language explanation algorithms for the lung cancer computer-aided diagnosis system. Artif. Intell. Med. 2020, 108, 101952

Song, Z.; Liu, T.; Shi, L.; Yu, Z.; Shen, Q.; Xu, M.; Huang, Z.; Cai, Z.; Wang, W.; Xu, C.; et al. The deep learning model combining CT image and clinicopathological information for predicting ALK fusion status and response to ALK-TKI therapy in non-small cell lung cancer patients. Eur. J. Nucl. Med. Mol. Imaging 2021, 48, 361–371

Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021, 71, 209–249.

Lin, Chun-Hui, Cheng-Jian Lin, Yu-Chi Li, and Shyh-Hau Wang. "Using generative adversarial networks and parameter optimization of convolutional neural networks for lung tumor classification." Applied Sciences 11, no. 2 (2021): 480.

Dafni Rose, J., K. Jaspin, and K. Vijayakumar. "Lung cancer diagnosis based on image fusion and prediction using CT and PET image." Signal and image processing techniques for the development of intelligent healthcare systems (2021): 67-86.

Downloads

Published

2025-05-22

How to Cite

1.
Bonthala S, A S, K S. Hierarchical Multiclass Classification Of Non-Small Cell Lung Cancer Leveraging Efficientnet-B3 For Enhanced Diagostic Precision. J Neonatal Surg [Internet]. 2025May22 [cited 2025Sep.20];14(26S):633-44. Available from: https://www.jneonatalsurg.com/index.php/jns/article/view/6338

Similar Articles

You may also start an advanced similarity search for this article.