Formulation And Characterization Of Nicardipine Hydrochloride Solid Dispersions And Oro dispersible Tablets Using Natural Seed Starch as Super disintegrant
Keywords:
Nicardipine Hydrochloride, Solid Dispersions, Orodispersible Tablets, Croscarmellose SodiumAbstract
The current research aimed to improve the solubility and rate of dissolution of Nicardipine HCl, which is a drug that has low water solubility. This was achieved by utilizing solid dispersions and orodispersible tablets made from ESS4 (Entada scandens seed starch). The starches were extracted using water and alkali as solvents. The study evaluated the chemical composition and physical properties of seed starches. The solid dispersions were made utilizing a modified method of evaporating solvents with ESS4 as carrier in various amounts. Direct compression (DC) technique has been utilized in making tablets with optimized solid dispersions of Nicardipine HCl and various quantities of SSG (Sodium Starch Glycolate) along with CCS (Croscarmellose Sodium). Optimized solid dispersions as well as orodispersible tablets were also subjected for characterization including Scanning Electron Microscopy (SEM) and FTIR (Fourier Transform Infra-Red Spectroscopy). These findings indicated that ESS4 which was made using a 0.5% sodium hydroxide (ESS4). Demonstrated superior physicochemical characteristics compared to other starches. The solid dispersions made with ESS4 exhibited more drug release. The optimized dispersion NS4 was employed for the preparation of orodispersible tablets with CCS and SSG. The prepared tablets exhibited pre as well as post compression parameters within specified limits. The in-vitro drug release studies exhibited release of drugs more quickly. FTIR research demonstrated that there has been no drug-excipient interaction. Moreover, SEM images revealed nature of drug and excipients used. The study determined that the ESS4 has exceptional super disintegrant properties, indicating its potential application in developing an innovative formulation for the treatment of angina utilizing Nicardipine HCl
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References
Jindal. Review on solubility: A mandatory tool for pharmaceuticals. International Research Journal of Pharmacy. 8(11):11-5, 2017.
Saharan, Kukkar, Kataria, Gera, Choudhury. Dissolution enhancement of drugs. Part I: technologies and effect of carriers. International Journal of Health Research.;2(2), 2009.
Lewis, Udupa, Atin. Solid dispersions: a review. Pak J Pharm Sci. Apr;22(2):234-46, 2009.
Chiou, Riegelman. Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin. Journal of pharmaceutical sciences. Dec 1;58(12):1505-10, 1969.
Pawar, Barhate. Solubility enhancement (Solid Dispersions) novel boon to increase bioavailability. Journal of Drug Delivery and Therapeutics. Mar 22;9(2):583-90, 2019.
Tekade, Yadav. A review on solid dispersion and carriers used therein for solubility enhancement of poorly water soluble drugs. Advanced pharmaceutical bulletin. Jul;10(3):359, 2020.
Siripruekpong, Issarachot, Kaewkroek, Wiwattanapatapee. Development of Gastroretentive Carriers for Curcumin-Loaded Solid Dispersion Based on Expandable Starch/Chitosan Films. Molecules. Jan 1;28(1):361, 2023.
Jyoti Patil, Dr. Arunkumar Walikar, Preparation and Evaluation of Melt in Mouth Tablets of Nicardipine HCl by Using Liquisolid Technique International Journal of Pharmaceutical Research and Applications, Volume 10, Issue 1 Jan - Feb 2025, pp: 1605-1618
Chabria NB, Narayanan N. Formulation and in-vitro evaluation of oral floating Nicardipine HCl hydrochloride tablets. Hygeia. JD Med. 2013; 5(2):63-75.
https://www.drugbank.ca/drugs/DB00622/28/03/2020.
Mannem V, Suryadevara V, Doppalapudi S. Formulation and evaluation of telmisartan solid dispersions using Entada scandens seed starch and poloxamer-188 as superdisintegrants. Asian J Pharm Clin Res;11(9):474-81, 2018.
Venkatarao Mannem, Vidyadhara Suryadevara, Sandeep Doppalapudi.Formulation and Evaluation of Telmisartan Solid Dispersions Using Entada Scandens Seed Starch And Poloxamer-188 as Superdisintegrants, Asian J Pharm Clin Res, Vol 11, Issue 9, 474-481, 2018.
Xueling Z, Hao M, Mei L, Ying L, Le S and Wenqian D. Research progress on properties of pre-gelatinized starch and its application in wheat flour products. Grain and Oil Science Technology, 5(2): 87-97, 2022.
Kokott M, Klinken S, Breitkreutz J, Wiedey R. Downstream processing of amorphous solid dispersions into Orodispersible tablets. Int J Pharm. 2023;631:122493. doi: 10.1 016/j.ijpharm.2022.122493, PMID 36528189.
Dasari N, Kumar CSP, Gummadi RK, Pindiprolu SSSK, Balla S, Masa A, et al. Application of Novel Natural Sweetening Agent-Stevia in Formulation, Evaluation of Nicardipine HCl Hydrochloride Orodispersable for Rapid Absorption. Indian J of Pharmaceutical Education and Research. 2024;58(1s):s176-s186.
Preethi GB, Sayan B, Shivakumar HN and Ravi KM. Formulation of fast-dissolving tablets of Doxazosin mesylate drug by direct compression method, International Journal of Applied Pharmaceutics, 9(5): 22-28, 2017.
Balakrishna T, Vidyadhara S, Murthy TEGK, Viswanadh K and Tejasri M. Formulation and evaluation of Orodispersible tablets of Zolmitriptan,Asian Journal of Pharmaceutics, 10(4): S683-S687, 2016.
Vidyadhara S, Sasidhar R, Lakshmi H, Vijetha P and Vijetha K. Studies on jackfruit seed starch as a novel natural superdisintegrant for the design and evaluation of irbesartan fast dissolving tablets. Integrative Medicine Research,6(3): 280-291, 2017.
Fateatun N, Jiaur R, Sultan M, Sorifa A, Aminul IT and Maruf A. Physicochemical properties of flour and extraction of starch from jackfruit seed. International Journal of Nutrition and Food Sciences, 3(4): 347-354, 2014.
Joerg F, Henrike B and Slawomir O. Strach and glycogen analyses: methods and techniques, Biomolecules, 10(7): 1020, 2020.
Nargis Y, Fiza N, Rehana S, Hafiza A and Adnan S. Water solubility and water absorption index of extruded product from rice and carrot blend, Journal of Pharmacognosy and Phytochemistry, 6(6): 2165-2168, 2017.
Shrawan B, Helen C and Niall J R. Investigation into the solid state properties an dissolution profile of spray dried ternary amorphous solid dispersions: a rational step toward the design and development of a multicomponent amorphous system. Molecular Pharmaceutics, 15(9): 3796-3812, 2018.
Nor K A, Nor M S and Meor M A. “Roles of polysaccharides in transdermal drug delivery system and future prospects”, Journal of Applied Pharmaceutical Science, 8(3): 141-157, 2018.
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